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Elingarami, S. (2015). Study on the Influence of Genetic Polymorphisms on Gastric Cancer Susceptibility in Northern Jiangsu(China).
Abstract: Gastric cancer is one of the most common cancers in the world, accounting for 8 of the total cancer cases and resulting in 10 of total mortality from cancer casesworldwide.Over 70 of new cases and deaths occur in developing countries,including Eastern Africa and China.Previous epidemiological investigations indicatedthat smoking, alcohol drinking, and Helicobacter pylori infection, may be the majorrisk factors for gastric cancer.However, only a small proportion of the peopleconstantly exposed to these environmental factors eventually develop gastric cancer,indicating that host genetic factors may have critical functions in gastriccarcinogenesis.<br>A molecular epidemiological hospital based case-control study was thusconducted in this thesis study to investigate the independent roles of single nucleotidepolymorphisms (SNPs) in base excision repair (BER) genes (APE1 and NEIL2),carcinogen metabolism gene (CYP2E1) and tumor suppressor pathway gene (MDM2)in causing gastric cancer.The aim was to evaluate the potential association betweenthe single nucleotide polymorphisms (SNPs) in the mentioned genes and theirsusceptibility to gastric cancer in a Northern Jiangsu population.Also, the NEIL2gene mRNA expression was associated with the studied NEIL2 SNP genotypes, toassess whether the NEIL2 genotypes have influence on the NEIL2 mRNA (henceprotein) expression.Moreover, an SNP genotyping assay based on novel magneticnanoparticles was used to genotype the NEIL2 SNP (rs804270) in order to assess theeffectiveness of nanomaterials in designing new SNP detection assays.
Keywords: Gastric Cancer DNA Repair Susceptibility Genetic Polymorphisms
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().Cancer and Thrombosis. Cancer and Thrombosis, (4), 147–148.
Abstract: Relationship between cancer and thromboembolic disease, the research has been going on for more than a century.Armand trousseau in 1865 first reported the formation of venous thrombosis prone patients with gastric cancer.
Keywords: Cancer Thrombosis
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Deo, A. K. (). Breast cancer stem-like cells and breast cancer therapy. Breast cancer stem-like cells and breast cancer therapy, (5), 530–543.
Abstract: Until the early 1990s, human cancers were considered a morphologically heterogeneous population of cells. In 1997, Bonnet et al[1] demonstrated that a small population of leukemia cells was able to differentiate in vivo into leukemic blasts, indicating that the leukemic clone was organized as a hierarchy; this was subsequently denoted as cancer stem like cells (CSCs). CSCs are cancer cells that possess characteristics associated with normal stem cells and have the specific ability to give rise to all cell types found in a particular cancer. One reason for the failure of traditional anti tumor therapies might be their inability to eradicate CSCs. Therefore, therapies must identify and destroy CSCs in both primary and metastatic tumors.
Keywords: Breast cancer stem cells Signaling pathway Resistance
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