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Author (up) Luther, M.K.; Mermel, L.A.; LaPlante, K.L. url  doi
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  Title Comparison of telavancin and vancomycin lock solutions in eradication of biofilm-producing staphylococci and enterococci from central venous catheters Type Journal Article
  Year 2016 Publication American Journal of Health-System Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists Abbreviated Journal Am J Health Syst Pharm  
  Volume 73 Issue 5 Pages 315-321  
  Keywords Aminoglycosides/*administration & dosage; Anti-Bacterial Agents/administration & dosage; Biofilms/*drug effects; Catheter-Related Infections/diagnosis/*drug therapy; Central Venous Catheters/microbiology; Enterococcus/*drug effects/isolation & purification; Humans; Pharmaceutical Solutions/administration & dosage; Staphylococcus/*drug effects/isolation & purification; Staphylococcus aureus/drug effects/isolation & purification; Staphylococcus epidermidis/drug effects/isolation & purification; Vancomycin/*administration & dosage  
  Abstract PURPOSE: Results of a study of the activity of antibiotic lock solutions of vancomycin and telavancin against biofilm-forming strains of Staphylococcus epidermidis, Enterococcus faecalis, and Staphylococcus aureus are reported. METHODS: An established in vitro central venous catheter model was used to evaluate lock solutions containing vancomycin (5 mg/mL) or telavancin (5 mg/mL), with and without preservative-containing heparin sodium (with 0.45% benzyl alcohol) 2500 units/mL, heparin, and 0.9% sodium chloride solution. Lock solutions were introduced after 24-hour bacterial growth in catheters incubated at 35 degrees C. After 72 hours of exposure to the lock solutions, catheters were drained, flushed, and cut into segments for quantification of colony-forming units. RESULTS: Against S. epidermidis, vancomycin and telavancin (with or without heparin) had similar activity. Against E. faecalis, vancomycin alone was more active than telavancin alone (p < 0.01). Against S. aureus, vancomycin plus heparin had activity similar to that of vancomycin alone; both lock agents had greater activity than telavancin (p < 0.02). The addition of heparin was associated with reduced activity of the vancomycin lock solution against S. epidermidis and E. faecalis (p < 0.01). Telavancin activity was not significantly changed with the addition of heparin. CONCLUSION: In a central venous catheter model, vancomycin and telavancin activity was similar in reducing biofilm-producing S. epidermidis. However, vancomycin was more active than telavancin against E. faecalis and S. aureus. None of the tested agents eradicated biofilm-forming strains. The addition of preservative-containing heparin sodium 2500 units/mL to vancomycin was associated with reduced activity against S. epidermidis and E. faecalis.  
  Address Rhode Island Infectious Diseases Research Program, Providence Veterans Affairs Medical Center, Providence, RI, and Department of Pharmacy Practice, University of Rhode Island, Kingston, RI. kerrylaplante@uri.edu  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1079-2082 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:26896504 Approved no  
  Call Number ref @ user @ Serial 100120  
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