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Author Oncu, S. url  doi
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  Title Optimal dosage and dwell time of ethanol lock therapy on catheters infected with Candida species Type Journal Article
  Year 2014 Publication Clinical Nutrition (Edinburgh, Scotland) Abbreviated Journal Clin Nutr  
  Volume 33 Issue 2 Pages 360-362  
  Keywords Candida/drug effects; Candidemia/*prevention & control; Catheter-Related Infections/*prevention & control; Catheterization, Central Venous; Catheters, Indwelling/*microbiology; Cross Infection/microbiology/*prevention & control; Dose-Response Relationship, Drug; Ethanol/*pharmacology; Humans; Incidence; Sterilization/*methods; Candida; Catheter; Ethanol; Infection; Lock  
  Abstract BACKGROUND & AIMS: Anti-infective lock therapy is a treatment strategy in conjunction with systemic antifungal agents for the treatment of intravascular catheter infections caused by fungi. In this study, the optimal dosage and dwell time of ethanol lock solution (ELS) effective against catheters infected by Candida species were assessed. METHODS: Biofilm forming isolates of Candida albicans, Candida parapsilosis and Candida tropicalis was used as the study isolates. Infected catheters were exposed to ELS at 20%, 30%, 40%, 60% and 80% strength for a variety dwell times (15 min, 30 min, 1 h, 2 h, 4 h, 8 h, 12 h and 24 h). Fungal eradication was evaluated by the quantitative culture techniques. RESULTS: ELS's with 40% and greater strength sterilized the catheters within 30 min. Lower strength of ELS's (20% and 30%) sterilized the catheters in 24 h and 2 h, respectively. CONCLUSIONS: According to the study, lock therapy with >/=40% ethanol for 30 min appear to be the optimal schedule in sterilizing Candida infected catheters. Ethanol lock therapy with such concentrations and dwell time may be a useful adjunct to systemic anti-fungal antibiotics in sterilizing (and cleaning) and eradicating fungal catheter related infections in the hope of preserving crucial central venous access.  
  Address Adnan Menderes University Medical Faculty, Department of Infectious Diseases and Clinical Microbiology, 09100 Aydin, Turkey. Electronic address: soncu@dr.com  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0261-5614 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:23672805 Approved no  
  Call Number ref @ user @ Serial (down) 100546  
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