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Author (up) Capria, S.; De Angelis, F.; Gentile, G.; Trisolini, S.M.; Brocchieri, S.; Canichella, M.; Chiusolo, P.; Micozzi, A.; Foa, R.; Meloni, G. url  doi
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  Title Complete remission obtained with azacitidine in a patient with concomitant therapy related myeloid neoplasm and pulmonary mucormycosis Type Journal Article
  Year 2013 Publication Mediterranean Journal of Hematology and Infectious Diseases Abbreviated Journal Mediterr J Hematol Infect Dis  
  Volume 5 Issue 1 Pages e2013048  
  Keywords  
  Abstract Mucormycosis is the third cause of invasive mycosis after candidiasis and aspergillosis in AML patients, representing a poor prognostic factor associated with a high rate of fatal outcome. We report a case of a patient with AML and a concomitant pulmonary mucormycosis at diagnosis, who obtained a complete remission both of her AML and of the fungal infection. The incidence of the infection at the onset of leukemia is extremely unusual, and, to our knowledge, the sporadic cases reported in the literature are included in heterogeneous series retrospectively examined. In our case, Liposomal Amphotericin B as single agent appeared incapable of controlling the infection, so anti-infective therapy was intensified with posaconazole and simultaneously antileukemic treatment with 5-azacitidine was started, with the understanding that the only antifungal treatment would not have been able to keep the infection under control for a long time if not associated with a reversal of neutropenia related to the disease. We observed a progressive improvement of the general conditions, a healing of pneumonia and a complete remission of the leukemic disease, suggesting that a careful utilization of the new compounds available today, in terms of both antifungal and antileukemic treatment, may offer a curative chance a patient who would have otherwise been considered unfit for a potentially curative therapeutic strategy.  
  Address Department of Cellular Biotechnologies and Hematology, “Sapienza” University of Rome, Rome, Italy  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 2035-3006 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:23936619 Approved no  
  Call Number refbase @ user @ Serial 23581  
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