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Author (up) Fan, Y.; Wang, S.; Hernandez, J.; Yenigun, V.B.; Hertlein, G.; Fogarty, C.E.; Lindblad, J.L.; Bergmann, A. url  doi
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  Title Genetic models of apoptosis-induced proliferation decipher activation of JNK and identify a requirement of EGFR signaling for tissue regenerative responses in Drosophila Type Journal Article
  Year 2014 Publication PLoS Genetics Abbreviated Journal PLoS Genet  
  Volume 10 Issue 1 Pages e1004131  
  Keywords  
  Abstract Recent work in several model organisms has revealed that apoptotic cells are able to stimulate neighboring surviving cells to undergo additional proliferation, a phenomenon termed apoptosis-induced proliferation. This process depends critically on apoptotic caspases such as Dronc, the Caspase-9 ortholog in Drosophila, and may have important implications for tumorigenesis. While it is known that Dronc can induce the activity of Jun N-terminal kinase (JNK) for apoptosis-induced proliferation, the mechanistic details of this activation are largely unknown. It is also controversial if JNK activity occurs in dying or in surviving cells. Signaling molecules of the Wnt and BMP families have been implicated in apoptosis-induced proliferation, but it is unclear if they are the only ones. To address these questions, we have developed an efficient assay for screening and identification of genes that regulate or mediate apoptosis-induced proliferation. We have identified a subset of genes acting upstream of JNK activity including Rho1. We also demonstrate that JNK activation occurs both in apoptotic cells as well as in neighboring surviving cells. In a genetic screen, we identified signaling by the EGFR pathway as important for apoptosis-induced proliferation acting downstream of JNK signaling. These data underscore the importance of genetic screening and promise an improved understanding of the mechanisms of apoptosis-induced proliferation.  
  Address University of Massachusetts Medical School, Department of Cancer Biology, Worcester, Massachusetts, United States of America ; Graduate Program in Developmental Biology, Baylor College of Medicine, Houston, Texas, United States of America ; MD Anderson Cancer Center, Department of Biochemistry & Molecular Biology, Houston, Texas, United States of America  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1553-7390 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:24497843 Approved no  
  Call Number refbase @ admin @ Serial 35558  
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