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Author  |
Ragauskas, A.; Bartusis, L.; Piper, I.; Zakelis, R.; Matijosaitis, V.; Petrikonis, K.; Rastenyte, D. |
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Title |
Improved diagnostic value of a TCD-based non-invasive ICP measurement method compared with the sonographic ONSD method for detecting elevated intracranial pressure |
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Journal Article |
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Year |
2014 |
Publication |
Neurological Research |
Abbreviated Journal |
Neurol Res |
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1743132813y0000000308 |
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Keywords |
Absolute intracranial pressure,; Diagnostic reliability,; Doppler technology,; Non-invasive measurement,; Optic nerve sheath diameter |
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Abstract |
Objectives: To compare the diagnostic reliability of optic nerve sheath diameter (ONSD) ultrasonography with a transcranial Doppler (TCD)-based absolute intracranial pressure (ICP) value measurement method for detection of elevated ICP in neurological patients. The ONSD method has been only tested previously on neurosurgical patients. Methods: A prospective clinical study of a non-invasive ICP estimation method based on ONSD correlation with ICP and an absolute ICP value measurement method based on a two-depth TCD technology has recruited 108 neurological patients. Ninety-two of these patients have been enrolled in the final analysis of the diagnostic reliability of ONSD ultrasonography and 85 patients using the absolute ICP value measurement method. All non-invasive ICP measurements were compared with 'Gold Standard' invasive cerebrospinal fluid (CSF) pressure measurements obtained by lumbar puncture. Receiver-operating characteristic (ROC) analysis has been used to investigate the diagnostic value of these two methods. Results: The diagnostic sensitivity, specificity, and the area under the ROC curve (AUC) of the ONSD method for detecting elevated intracranial pressure (ICP >14.7 mmHg) were calculated using a cutoff point of ONSD at 5.0 mm and found to be 37.0%, 58.5%, and 0.57, respectively. The diagnostic sensitivity, specificity, and AUC for the non-invasive absolute ICP measurement method were calculated at the same ICP cutoff point of 14.7 mmHg and were determined to be 68.0%, 84.3%, and 0.87, respectively. Conclusions: The non-invasive ICP measurement method based on two-depth TCD technology has a better diagnostic reliability on neurological patients than the ONSD method when expressed by the sensitivity and specificity for detecting elevated ICP >14.7 mmHg. |
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English |
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0161-6412 |
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PMID:24620972 |
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refbase @ user @ |
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47375 |
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