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Author (up) Chi, Y.; Wang, Y.-hua; Yang, L. url  openurl
  Title [The investigation of retinal nerve fiber loss in Alzheimer's disease] Type Journal Article
  Year 2010 Publication [Zhonghua yan ke za zhi] Chinese Journal of Ophthalmology Abbreviated Journal Zhonghua Yan Ke Za Zhi  
  Volume 46 Issue 2 Pages 134-139  
  Keywords Aged; Aged, 80 and over; Alzheimer Disease/*pathology; Case-Control Studies; Female; Humans; Male; Middle Aged; Nerve Fibers/*pathology; Retinal Ganglion Cells/*pathology  
  Abstract OBJECTIVE: To determine if there are retinal abnormalities in Alzheimer's disease and if retinal changes are one of the causes of the visual symptom, and if the changes of retina thickness correlated with the severity of dementia. METHODS: Case-control study. Twelve patients of Alzheimer's disease and seventeen normal controls were included. General eye examinations, mini-mental state examination (MMSE) score and OCT were performed on each patient. Independent-samples t test was used to compare the results obtained from these two groups. RESULTS: The retinal nerve fiber layer (RNFL thickness) overall:Alzheimer's (93.18 +/- 11.36) microm, control (99.44 +/- 8.88) microm, macula thickness min: Alzheimer's (204.00 +/- 52.06) microm, control (211.36 +/- 49.09) microm; inner 1 mm: Alzheimer's (232.50 +/- 23.37) microm, control (242.79 +/- 40.36) microm; between 1-3 mm: Alzheimer's (289.42 +/- 21.37) microm, control (298.43 +/- 23.30) microm; between 3 – 6 mm: Alzheimer's (256.67 +/- 20.04) microm, control (262.86 +/- 20.19) microm was thinner in the patients with Alzheimer's disease. Macula volume inner 1 mm: Alzheimer's (0.183 +/- 0.018) m(3), control (0.188 +/- 0.031) m(3): between 1 – 3 mm: Alzheimer's (1.819 +/- 0.134) m(3), control (1.875 +/- 0.147) m(3); between 3 – 6 mm Alzheimer's (5.443 +/- 0.424) m(3), control (5.571 +/- 0.428) m(3) in the Alzheimer's diseases patients was smaller than that of the controls. There was significant difference (t = -2.519, P < 0.05) in RNFL thickness of the superior quadrant between the two groups Alzheimer's disease (115.09 +/- 14.05) microm, control (129.23 +/- 10.69) microm. CONCLUSIONS: There is retinal nerve fiber loss in patients with Alzheimer's disease, which may be responsible for the visual symptoms. The retinal nerve fiber loss is obviously in the superior quadrant, and it is correlated positively to the severity of dementia.  
  Address Department of Ophthalmology, Peking University First Hospital, Beijing 100034, China  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Chinese Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0412-4081 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:20388347 Approved no  
  Call Number ref @ user @ Serial 67836  
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