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Author (up) Takeoka, Y.; Yamamura, R.; Iwasaki, S.; Morioka, J. url  openurl
  Title [MR imaging provides important clues for the diagnosis of benign intracranial hypertension by all-trans retinoic acid in a patient with acute promyelocytic leukemia] Type Journal Article
  Year 2004 Publication [Rinsho Ketsueki] The Japanese Journal of Clinical Hematology Abbreviated Journal Rinsho Ketsueki  
  Volume 45 Issue 2 Pages 139-143  
  Keywords Adult; Humans; Intracranial Hypertension/*chemically induced/*diagnosis; Leukemia, Promyelocytic, Acute/*drug therapy; *Magnetic Resonance Imaging; Male; Tretinoin/*adverse effects  
  Abstract We report a case of benign intracranial hypertension (BIH) caused by all-trans retinoic acid (ATRA) in a patient with acute promyelocytic leukemia. A 21-year-old male was admitted to our hospital with pancytopenia. He was diagnosed as having acute promyelocytic leukemia due to increased promyelocytes, and PML-RAR alpha chimeric mRNA was detected. The administration of ATRA and idarubicin was started immediately. After 26 days of the chemotherapy, he complained of diplopia. Ophthalmologic examination revealed bilateral papilledema and hemorrhage. The cerebrospinal fluid showed an increase in pressure, but no other abnormalities. Computed tomography showed no intracranial abnormalities. The orbital MR imaging showed distension of the perioptic subarachnoid space and flattening of the posterior sclera. A diagnosis of BIH was made. After the discontinuation of ATRA, the symptoms improved and the MR abnormalities disappeared. As far as we know, there have been no reports illustrating MR abnormalities of BIH caused by ATRA, for the diagnosis and monitoring of which orbital MR imaging can provide important clues.  
  Address Clinical Hematology and Clinical Diagnostics, Osaka City University, Graduate School of Medicine  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Japanese Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0485-1439 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:15045822 Approved no  
  Call Number ref @ user @ Serial 78570  
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