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Author (up) Paldino, M.J.; Hedges, K.; Rodrigues, K.M.; Barboriak, D.P. url  doi
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  Title Repeatability of quantitative metrics derived from MR diffusion tractography in paediatric patients with epilepsy Type Journal Article
  Year 2014 Publication The British Journal of Radiology Abbreviated Journal Br J Radiol  
  Volume 87 Issue 1037 Pages 20140095  
  Keywords Anisotropy; Child; Diffusion Tensor Imaging/*methods; Epilepsy/*pathology; Female; Humans; Image Interpretation, Computer-Assisted; Male; Reproducibility of Results; Retrospective Studies  
  Abstract OBJECTIVE: To quantify the test-retest repeatability of mean diffusivity (MD) and fractional anisotropy (FA) derived from diffusion tensor imaging (DTI) tractography in a cohort of paediatric patients with localization-related epilepsy. METHODS: 30 patients underwent 2 DTI acquisitions [repetition time/echo time (ms), 7000/90; flip, 90 degrees ; b-value, 1000 s mm(-2); voxel (mm), 2 x 2 x 2]. Two observers used Diffusion Toolkit and TrackVis ( www.trackvis.org ) to segment and analyse the following tracts: corpus callosum, corticospinal tracts, arcuate fasciculi, inferior longitudinal fasciculi and inferior fronto-occipital fasciculi. Mean MD and mean FA were calculated for each tract. Each observer independently analysed one of the DTI data sets for every patient. RESULTS: Segmentation identified all tracts in all subjects, except the arcuate fasciculus. There was a highly consistent relationship between repeated observations of MD (r = 0.993; p < 0.0001) and FA (r = 0.990; p < 0.0001). For each tract, coefficients of variation ranged from 0.9% to 2.1% for MD and from 1.5% to 2.8% for FA. The 95% confidence limits (CLs) for change ranged from 2.8% to 6% for MD and from 4.3% to 8.6% for FA. For the arcuate fasciculus, Cohen's kappa for agreement between the observers (identifiable vs not identifiable) was 1.0. CONCLUSION: We quantified the repeatability of two commonly utilized scalar metrics derived from DTI tractography. For an individual patient, changes greater than the repeatability coefficient or 95% CLs for change are unlikely to be related to variability in their measurement. ADVANCES IN KNOWLEDGE: Reproducibility of these metrics will aid in the design of future studies and might one day be used to guide management in patients with epilepsy.  
  Address Department of Radiology, Children's Hospital Boston and Harvard Medical School, Boston, MA, USA  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0007-1285 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:24720623 Approved no  
  Call Number ref @ user @ Serial 90483  
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