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Author (up) Wang, I.-J.; Tung, T.-H.; Tang, C.-S.; Zhao, Z.-H. url  doi
  Title Allergens, air pollutants, and childhood allergic diseases Type Journal Article
  Year 2016 Publication International Journal of Hygiene and Environmental Health Abbreviated Journal Int J Hyg Environ Health  
  Volume 219 Issue 1 Pages 66-71  
  Keywords Air pollutant; Allergen; Asthma  
  Abstract BACKGROUND: The synergistic effect of allergens and air pollutants on the risk of allergic diseases is unclear. OBJECTIVE: To evaluate the joint effect of outdoor pollutants and indoor allergens on the risk of allergic diseases. METHODS: We enrolled 2661 kindergarten children from the CEAS cohort. Data on allergic diseases and environmental exposure were collected. Skin prick tests were performed. Individual exposure to air pollution was estimated using a geographic information system with the mean concentration of air pollutants. Multiple logistic regression analysis was performed to estimate the association between air pollutants, allergen exposure and the risk of allergic diseases with adjustments for potential confounders. RESULTS: Overall, 12.6% of the children had asthma, 30.0% had allergic rhinitis (AR), and 14.4% had atopic dermatitis (AD). Mite sensitization significantly increased the risk of AD, AR, and asthma (OR (95%CI) 2.15 (1.53-3.03), 1.94 (1.46-2.58), and 2.31 (1.63-3.29), respectively). Exposure to PM10, PM2.5, CO, and O3 was associated with asthma (OR (95% CI) 1.39 (1.03-1.87), 1.45 (1.07-1.97), 1.36 (1.01-1.83), and 0.68 (0.51-0.92), respectively). PM2.5 may have increased the risk of AR (OR (95% CI) 1.54 (1.03-2.32). Mite sensitization showed a synergistic effect with PM2.5 on the development of asthma (p<0.001). Moreover, mite allergens may modify the effect of air pollutants on allergic diseases. CONCLUSION: Dust mites and PM2.5 play an important role on the risk of asthma and AR. Exposure to PM2.5 and mite allergens had a synergistic effect on the development of asthma. Avoiding co-exposure to allergens and air pollutants is important.  
  Address College of Public Health, Fu Jen Catholic University, Taipei, Taiwan  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1438-4639 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:26404109 Approved no  
  Call Number ref @ user @ Serial 90834  
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