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Author (up) Yang, B.; Shi, M.-Q.; Li, Z.-H.; Yang, J.-J.; Li, D. url  doi
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  Title Fish, Long-Chain n-3 PUFA and Incidence of Elevated Blood Pressure: A Meta-Analysis of Prospective Cohort Studies Type Journal Article
  Year 2016 Publication Nutrients Abbreviated Journal Nutrients  
  Volume 8 Issue 1 Pages  
  Keywords blood pressure; fish; meta-analysis; n-3 PUFA  
  Abstract Results from prospective cohort studies on fish or long-chain (LC) n-3 polyunsaturated fatty acid (PUFA) intake and elevated blood pressure (EBP) are inconsistent. We aimed to investigate the summary effects. Pertinent studies were identified from PubMed and EMBASE database through October 2015. Multivariate-adjusted risk ratios (RRs) for incidence of EBP in the highest verses the bottom category of baseline intake of fish or LC n-3 PUFA were pooled using a random-effects meta-analysis. Over the follow-up ranging from 3 to 20 years, 20,497 EBP events occurred among 56,204 adults from eight prospective cohort studies. The summary RR (SRR) was 0.96 (95% CI: 0.81, 1.14; I(2) = 44.70%) for fish in four studies, and 0.73 (95% CI: 0.60, 0.89; I(2) = 75.00%) for LC n-3 PUFA in six studies (three studies for biomarker vs. three studies for diet). Circulating LC n-3 PUFA as biomarker was inversely associated with incidence of EBP (SRR: 0.67; 95% CI: 0.55, 0.83), especially docosahexaenoic acid (SRR: 0.64; 95% CI: 0.45, 0.88), whereas no significant association was found for dietary intake (SRR: 0.80; 95% CI: 0.58, 1.10). The present finding suggests that increased intake of docosahexaenoic acid to improve its circulating levels may benefit primary prevention of EBP.  
  Address Department of Food Science and Nutrition, Zhejiang University, Hangzhou 310058, China. duoli@zju.edu.cn  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 2072-6643 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:26805877 Approved no  
  Call Number ref @ user @ Serial 92550  
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