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Author (up) Heuer, A.; Kirkeby, A.; Pfisterer, U.; Jonsson, M.E.; Parmar, M. url  doi
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  Title hESC-derived neural progenitors prevent xenograft rejection through neonatal desensitisation Type Journal Article
  Year 2016 Publication Experimental Neurology Abbreviated Journal Exp Neurol  
  Volume 282 Issue Pages 78-85  
  Keywords Cyclosporine; Desensitisation; Immune response; Rejection; Stem cell; Transplant; Xenograft; hESC  
  Abstract Stem cell therapies for neurological disorders are rapidly moving towards use in clinical trials. Before initiation of clinical trials, extensive pre-clinical validation in appropriate animal models is essential. However, grafts of human cells into the rodent brain are rejected within weeks after transplantation and the standard methods of immune-suppression for the purpose of studying human xenografts are not always sufficient for the long-term studies needed for transplanted human neurons to maturate, integrate and provide functional benefits in the host brain. Neonatal injections in rat pups using human fetal brain cells have been shown to desensitise the host to accept human tissue grafts as adults, whilst not compromising their immune system. Here, we show that differentiated human embryonic stem cells (hESCs) can be used for desensitisation to achieve long-term graft survival of human stem cell-derived neurons in a xenograft setting, surpassing the time of conventional pharmacological immune-suppressive treatments. The use of hESCs for desensitisation opens up for a widespread use of the technique, which will be of great value when performing pre-clinical evaluation of stem cell-derived neurons in animal models.  
  Address Department of Experimental Medical Science, Developmental and Regenerative Neurobiology, Wallenberg Neuroscience Center, Lund University, Lund, Sweden; Lund Stem Cell Center, Lund University, Lund, Sweden. Electronic address: malin.parmar@med.lu.se  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0014-4886 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:27235932 Approved no  
  Call Number ref @ user @ Serial 95952  
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