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Author (up) Harris, R.A.; Shah, R.; Hollister, E.B.; Tronstad, R.R.; Hovdenak, N.; Szigeti, R.; Versalovic, J.; Kellermayer, R. url  doi
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  Title Colonic Mucosal Epigenome and Microbiome Development in Children and Adolescents Type Journal Article
  Year 2016 Publication Journal of Immunology Research Abbreviated Journal J Immunol Res  
  Volume 2016 Issue Pages 9170162  
  Keywords Adolescent; Child; Child, Preschool; Colitis, Ulcerative/genetics/immunology/microbiology/pathology; CpG Islands/immunology; Crohn Disease/genetics/immunology/microbiology/pathology; *DNA Methylation; Epigenesis, Genetic/*immunology; Female; Healthy Volunteers; Humans; Intestinal Mucosa/cytology/*immunology/microbiology; Male; Microbiota/genetics/*immunology; Proteins/genetics/immunology; RNA, Ribosomal, 16S/genetics; Sodium-Hydrogen Antiporter/genetics/immunology  
  Abstract Epigenetic and microbiome changes during pediatric development have been implicated as important elements in the developmental origins of inflammatory bowel diseases (IBDs) including Crohn's disease (CD) and ulcerative colitis (UC), which are linked to early onset colorectal cancer (CRC). Colonic mucosal samples from 22 control children between 3.5 and 17.5 years of age were studied by Infinium HumanMethylation450 BeadChips and, in 10 cases, by 454 pyrosequencing of the bacterial 16S rRNA gene. Intercalating age-specific DNA methylation and microbiome changes were identified, which may have significant translational relevance in the developmental origins of IBD and CRC.  
  Address Texas Children's Hospital, Houston, TX 77030, USA; Section of Pediatric Gastroenterology, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA; USDA/ARS Children's Nutrition Research Center, Houston, TX 77030, USA  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 2314-7156 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:27006956 Approved no  
  Call Number ref @ user @ Serial 96384  
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