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Author Meltzer, S.J.; Zhou, D.; Weinstein, W.M. url  openurl
  Title Tissue-specific expression of c-Ha-ras in premalignant gastrointestinal mucosae Type Journal Article
  Year 1989 Publication Experimental and Molecular Pathology Abbreviated Journal Exp Mol Pathol  
  Volume 51 Issue 3 Pages 264-274  
  Keywords Adenomatous Polyposis Coli/*genetics; Barrett Esophagus/*genetics; Colitis, Ulcerative/*genetics; Colon/physiology; Gene Amplification; Humans; Intestinal Mucosa/pathology/*physiology; Methylation; Oncogene Protein p21(ras)/*genetics; Oncogene Proteins/genetics; Phosphoproteins/genetics; Precancerous Conditions/genetics; Proto-Oncogene Proteins/genetics; Proto-Oncogene Proteins c-myc; *Proto-Oncogenes; Tumor Suppressor Protein p53  
  Abstract The molecular mechanisms underlying premalignant gastrointestinal diseases, such as ulcerative colitis and Barrett's esophagus, remain unknown. For this reason, the expression of the protooncogene c-Ha-ras was studied in ulcerative colitis and Barrett's esophagus. Total cellular RNA was extracted from different regions of the gastrointestinal tract in these two diseases. Expression of c-Ha-ras was greater in proximal than in distal colon and undetectable in Barrett's esophagus. These regional differences in expression were not seen with the control gene beta-actin or with the protooncogenes c-myc and p53. In order to evaluate structural factors contributing to expression, amplification and methylation of c-Ha-ras DNA were studied in these tissues by Southern and slot blotting. No amplification of c-Ha-ras or six other protooncogenes was detected. These data suggest tissue-specific regulation of c-Ha-ras expression in the gastrointestinal tract in certain premalignant disease states.  
  Address Department of Medicine, University of Maryland, Baltimore  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language (up) Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0014-4800 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:2557232 Approved no  
  Call Number ref @ user @ Serial 96511  
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