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Author  |
Kim, M.Y.; Park, S.-J.; Shim, J.W.; Song, Y.J.; Yang, K.; Park, S.-J.; Heo, K. |
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Title |
Accumulation of low-dose BIX01294 promotes metastatic potential of U251 glioblastoma cells |
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Journal Article |
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Year |
2017 |
Publication |
Oncology Letters |
Abbreviated Journal |
Oncol Lett |
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Volume |
13 |
Issue |
3 |
Pages |
1767-1774 |
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Keywords |
Bix01294; epithelial-mesenchymal transition; glioblastoma stem cells; metastasis |
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Abstract |
BIX01294 (Bix) is known to be a euchromatic histone-lysine N-methyltransferase 2 inhibitor and treatment with Bix suppresses cancer cell survival and proliferation. In the present study, it was observed that sequential treatment with low-dose Bix notably increases glioblastoma cell migration and metastasis. It was demonstrated that U251 cells sequentially treated with low-dose Bix exhibited induced characteristic changes in critical epithelial-mesenchymal transition (EMT) markers, including E-cadherin, N-cadherin, beta-catenin and zinc finger protein SNAI2. Notably, sequential treatment with Bix also increased the expression of cancer stem cell-associated markers, including sex determining region Y-box 2, octamer-binding transcription factor 4 and cluster of differentiation 133. Neurosphere formation was significantly enhanced in cells sequentially treated with Bix, compared with control cells (control: P=0.011; single treatment of Bix, P=0.045). The results of the present study suggest that accumulation of low-dose Bix enhanced the migration and metastatic potential of glioblastoma cells by regulating EMT-associated gene expression, which may be the cause of the altered properties of glioblastoma stem cells. |
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Address |
Research Center, Dongnam Institute of Radiological and Medical Science (DIRAMS), Busan 619-953, Republic of Korea |
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Language |
English |
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ISSN |
1792-1074 |
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Notes |
PMID:28454322 |
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no |
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Call Number |
ref @ user @ |
Serial |
96588 |
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