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Author (up) Batista, K.M.P.; Eulate-Beramendi, S.A. de; Pina, K.Y.A.R. de; Figueira, P.R.; Canal, A.F.; Chasin, J.M.A.; Meilan, A.; Ugalde, R.; Vega, I.F. url  doi
  Title Mesenchymal/proangiogenic factor YKL-40 related to glioblastomas and its relationship with the subventricular zone Type Journal Article
  Year 2017 Publication Folia Neuropathologica Abbreviated Journal Folia Neuropathol  
  Volume 55 Issue 1 Pages 14-22  
  Keywords Ykl-40; glioblastoma; glioblastoma stem cells; subventricular zone  
  Abstract <i>Glioblastoma is the most common primary brain tumor. Despite multimodality therapy with aggressive microsurgical resection and adjuvant chemotherapy and radiotherapy, the median survival is below 15 months. Glioblastomas are heterogeneous tumors with high resistance to most chemotherapeutic drugs. According to reliable evidence, YKL-40, one of the best investigated chitinase-like protein, may facilitate invasion, migration and angiogenesis, and could be also responsible for temozolomide resistance in glioblastoma, thus conferring a dismal prognosis. Previous studies have demonstrated that glioblastoma stem cells give rise to endothelial cells through an YKL-40 influence. Such factor is closely related to the subventricular zone. This review focuses on the most recent theories involving the possible relationship between topographic gliomagenesis related to the subventricular zone and YKL-40.</i>.  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1509-572X ISBN Medium  
  Area Expedition Conference  
  Notes PMID:28430288 Approved no  
  Call Number ref @ user @ Serial 96592  
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