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Author Batista, K.M.P.; Eulate-Beramendi, S.A. de; Pina, K.Y.A.R. de; Figueira, P.R.; Canal, A.F.; Chasin, J.M.A.; Meilan, A.; Ugalde, R.; Vega, I.F.
Title Mesenchymal/proangiogenic factor YKL-40 related to glioblastomas and its relationship with the subventricular zone Type Journal Article
Year 2017 Publication Folia Neuropathologica Abbreviated Journal Folia Neuropathol
Volume 55 Issue 1 Pages 14-22
Keywords Ykl-40; glioblastoma; glioblastoma stem cells; subventricular zone
Abstract <i>Glioblastoma is the most common primary brain tumor. Despite multimodality therapy with aggressive microsurgical resection and adjuvant chemotherapy and radiotherapy, the median survival is below 15 months. Glioblastomas are heterogeneous tumors with high resistance to most chemotherapeutic drugs. According to reliable evidence, YKL-40, one of the best investigated chitinase-like protein, may facilitate invasion, migration and angiogenesis, and could be also responsible for temozolomide resistance in glioblastoma, thus conferring a dismal prognosis. Previous studies have demonstrated that glioblastoma stem cells give rise to endothelial cells through an YKL-40 influence. Such factor is closely related to the subventricular zone. This review focuses on the most recent theories involving the possible relationship between topographic gliomagenesis related to the subventricular zone and YKL-40.</i>.
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Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN (up) 1509-572X ISBN Medium
Area Expedition Conference
Notes PMID:28430288 Approved no
Call Number ref @ user @ Serial 96592
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