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| Title | Comparison of therapeutic dosimetric data from passively scattered proton and photon craniospinal irradiations for medulloblastoma | Type | Journal Article | ||
| Year | 2012 | Publication | Abbreviated Journal | ||
| Volume | 7 | Issue | Pages | 116 | |
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| Abstract | For many decades, the standard of care radiotherapy regimen for medulloblastoma has been photon (megavoltage x-rays) craniospinal irradiation (CSI). The late effects associated with CSI are well-documented in the literature and are in-part attributed to unwanted dose to healthy tissue. Recently, there is growing interest in using proton therapy for CSI in pediatric and adolescent patients to reduce this undesirable dose. Previous comparisons of dose to target and non-target organs from conventional photon CSI and passively scattered proton CSI have been limited to small populations (n | ||||
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| ISSN | 1748-717x | ISBN | Medium | ||
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| Notes | Approved | no | |||
| Call Number | refbase @ user @ ref19 | Serial | 14313 | ||
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| Title | Formatting modifications in GRADE evidence profiles improved guideline panelists comprehension and accessibility to information. A randomized trial | Type | Journal Article | ||
| Year | 2012 | Publication | Abbreviated Journal | ||
| Volume | 65 | Issue | 7 | Pages | 748-755 |
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| Abstract | To determine the effects of formatting alternatives in Grading of Recommendations Assessment, Development, and Evaluation (GRADE) evidence profiles on guideline panelists' preferences, comprehension, and accessibility. | ||||
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| ISSN | 1878-5921 | ISBN | Medium | ||
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| Notes | Approved | no | |||
| Call Number | refbase @ user @ ref10 | Serial | 22060 | ||
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| Title | [a] | Type | Book Whole | ||
| Year | 2012 | Publication | Abbreviated Journal | ||
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| Corporate Author | Thesis | Ph.D. thesis | |||
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| Notes | Approved | no | |||
| Call Number | refbase @ admin @ ref5 | Serial | 24677 | ||
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| Title | Hors-série Le Monde : Une vie, une oeuvre, Jean-Jacques Rousseau | Type | Book Whole | ||
| Year | 2012 | Publication | Abbreviated Journal | ||
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| Publisher | Le Monde | Place of Publication | Editor | ||
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| Notes | Approved | no | |||
| Call Number | refbase @ user @ ref184 | Serial | 43185 | ||
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| Year | 2012 | Publication | Abbreviated Journal | ||
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| Abstract | Lead is a ubiquitous metal in the environment, and its adverse effects on human health are well documented. Lead interacts at multiple cellular sites and can alter protein function in part through binding to amino acid sulfhydryl and carboxyl groups on a wide variety of structural and functional proteins. In addition, lead mimics calcium and other divalent cations, and it induces the increased production of cytotoxic reactive oxygen species. Adverse effects associated with lead exposure can be observed in multiple body systems, including the nervous, cardiovascular, renal, hematologic, immunologic, and reproductive systems. Lead exposure is also known to induce adverse developmental effects in utero and in the developing neonate. Lead poses an occupational health hazard, and the Occupational Safety and Health Administration (OSHA) developed a lead standard for general industry that regulates many workplace exposures to this metal. The standard was promulgated in 1978 and encompasses several approaches for reducing exposure to lead, including the establishment of a permissible exposure limit (PEL) of 50 mug/m3 in air (an 8-hour time-weighted average [TWA]), exposure guidelines for instituting medical surveillance, guidelines for removal from and return to work, and other risk-management strategies. An action level of 30 mug/m3 (an 8-hour TWA) for lead was established to trigger medical surveillance in employees exposed above that level for more than 30 days per year. Another provision is that any employee who has a blood lead level (BLL) of 60 mug/dL or higher or three consecutive BLLs averaging 50 mug/dL or higher must be removed from work involving lead exposure. An employee may resume work associated with lead exposure only after two BLLs are lower than 40 mug/dL. Thus, maintaining BLLs lower than 40 mug/dL was judged by OSHA to protect workers from adverse health effects. The OSHA standard also includes a recommendation that BLLs of workers who are planning a pregnancy be under 30mug/dL. In light of knowledge about the hazards posed by occupational lead exposure, the Department of Defense (DOD) asked the National Research Council to evaluate potential health risks from recurrent lead exposure of firing-range personnel. Specifically, DOD asked the National Research Council to determine whether current exposure standards for lead on DOD firing ranges protect its workers adequately.The committee also considered measures of cumulative lead dose. Potential Health Risks to DOD Firing-Range Personnel from Recurrent Lead Exposure will help to inform decisions about setting new air exposure limits for lead on firing ranges, about whether to implement limits for surface contamination, and about how to design lead-surveillance programs for range personnel appropriately. | ||||
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| Corporate Author | National Research Council | Thesis | |||
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| Language | English | Summary Language | Original Title | ||
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| Notes | PMID:24901199 | Approved | no | ||
| Call Number | ref @ user @ | Serial | 90969 | ||
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