| Records |
| Author |
Gruber, O.; Kaufmann, M.; Köppendörfer, W.; Lackner, K.; Neuhauser, J. |
| Title |
Physics Background of the ASDEX Upgrade Project |
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Journal Article |
| Year |
1984 |
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Journal of Nuclear Materials |
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121 |
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407-414 |
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1991 |
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Scarfone, G.; Bergamini, A.; Noli, S.; Villa, A.; Cipriani, S.; Taccagni, G.; Vigano', P.; Candiani, M.; Parazzini, F.; Mangili, G. |
| Title |
Characteristics of clear cell ovarian cancer arising from endometriosis: a two center cohort study |
Type |
Observational Study |
| Year |
2014 |
Publication |
Gynecologic Oncology |
Abbreviated Journal |
Gynecol Oncol |
| Volume |
133 |
Issue |
3 |
Pages |
480-484 |
| Keywords |
Adenocarcinoma, Clear Cell/complications/*epidemiology/pathology; Adult; Age Distribution; Aged; Aged, 80 and over; Carcinoma, Endometrioid/complications/*epidemiology/pathology; Case-Control Studies; Cohort Studies; Endometriosis/*complications; Female; Humans; Middle Aged; Ovarian Neoplasms/complications/*epidemiology/pathology; Prognosis; Retrospective Studies; Clear cell ovarian cancer; Endometriosis; Endometriosis associated ovarian cancer |
| Abstract |
OBJECTIVE: Endometrioid and clear cell ovarian tumors have been referred to as “endometriosis associated ovarian cancers”. However, very few studies have compared clinical and prognostic features of endometriosis-associated cancers or cancers not associated with endometriosis according to specific histotypes. We have investigated clinical and histological features of the largest published series of clear cell ovarian cancers arising in endometriosis using a retrospective database. METHODS: Seventy three patients with a primary diagnosis of either pure clear cell ovarian cancer and mixed endometrioid-clear cell ovarian cancer have been divided into two groups according to the detection of cancer strictly arising from ovarian endometriosis or not (n=27 and n=46, respectively). Clinical and pathological data have been compared. RESULTS: Patients with clear cell carcinomas arising from endometriosis tend to be significantly younger (51.4+/-10.0 and 58.4+/-11.2years, p=0.02). FIGO stage, laterality, prevalence of pure versus mixed histology, and presence of synchronous endometrial carcinoma were not significantly different between the two groups. Unilateral ovarian involvement was more frequent in cases arising in endometriosis (85% vs 63%, p=0.04). Ascites was not found in any of the endometriosis-associated cancer cases vs 19.5% in patients without endometriosis. The presence of endometriosis did not affect 5-year overall survival rates. CONCLUSIONS: Endometriosis per se does not appear to be associated with a lower stage tumor or to predict prognosis in ovarian clear cell cancers. Unilateral involvement and reduced presence of ascites may be linked to the cystic nature of endometriosis which frequently presents as monolateral and in which associated tumors are more likely to be longer confined to the ovary before spreading. |
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Obstetrics and Gynecology Unit, San Raffaele Scientific Institute, Milano, Italy. Electronic address: mangili.giorgia@hsr.it |
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0090-8258 |
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PMID:24642093 |
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ref @ user @ |
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53990 |
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1234 |
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1234 |
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123 |
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123 |
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123 |
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123 |
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123 |
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54367 |
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Garrett, L.A.; Growdon, W.B.; Goodman, A.; Boruta, D.M.; Schorge, J.O.; del Carmen, M.G. |
| Title |
Endometriosis-associated ovarian malignancy: a retrospective analysis of presentation, treatment, and outcome |
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Journal Article |
| Year |
2013 |
Publication |
The Journal of Reproductive Medicine |
Abbreviated Journal |
J Reprod Med |
| Volume |
58 |
Issue |
11-12 |
Pages |
469-476 |
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Adenocarcinoma, Clear Cell/diagnosis/pathology/therapy; Adult; Carcinoma, Endometrioid/diagnosis/pathology/therapy; Endometriosis/*complications/epidemiology; Female; Humans; Middle Aged; Neoplasm Grading; Neoplasm Staging; Ovarian Neoplasms/*diagnosis/pathology/therapy; Postmenopause; Premenopause; Retrospective Studies; Survival Rate |
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OBJECTIVE: To investigate the relationship of age and tumors associated with endometriosis and outcome of different histologies of epithelial ovarian cancer arising from endometriosis. STUDY DESIGN: We identified cases of epithelial ovarian cancers with clear cell, endometrioid, or mixed clear cell and endometrioid histologies from January 2001 to March 2009. Tumors were classified as either “arising in” endometriosis, “associated with” endometriosis or “controls” (not associated with endometriosis). We collected information regarding patient demographics, past medical history, presentation at diagnosis, treatment, and outcome. RESULTS: Of 140 patients identified, 42 (30.0%) had clear cell, 92 (65.7%) had endometrioid, and 6 (4.3%) had mixed. Of those, 28.6% of tumors were associated with endometriosis (n = 40), 37.1% were arising in endometriosis (n = 52), and 34.3% were controls (n = 48). Premenopausal women had tumors that were more likely arising from or associated with endometriosis as compared to tumors in postmenopausal women (p = 0.005). Premenopausal patients were also more likely to present with early stage disease as compared to postmenopausal women (80.4% vs. 63.6%, p = 0.04) and better overall survival (p < 0.008). Survival analyses of the entire cohort showed that improved survival was associated with stage (p < 0.001), grade (p < 0.001), endometrioid histology (p < 0.005), and with tumors associated with or arising in endometriosis (p < 0.04). Multivariate analysis controlling for menopausal status showed the presence of endometriosis was no longer associated with a survival advantage (p = 0.08). CONCLUSION: The association with endometriosis does appear, at least in endometrioid tumors, to provide a survival benefit. Overall, menopausal status, stage, and grade are more powerful variables associated with improved survival. |
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Division of Gynecologic Oncology, Vincent Obstetrics and Gynecology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA |
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0024-7758 |
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PMID:24568040 |
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no |
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ref @ user @ |
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53991 |
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Kim, H.S.; Kim, T.H.; Chung, H.H.; Song, Y.S. |
| Title |
Risk and prognosis of ovarian cancer in women with endometriosis: a meta-analysis |
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Journal Article |
| Year |
2014 |
Publication |
British Journal of Cancer |
Abbreviated Journal |
Br J Cancer |
| Volume |
110 |
Issue |
7 |
Pages |
1878-1890 |
| Keywords |
Case-Control Studies; Cohort Studies; Endometriosis/*epidemiology; Female; Humans; Ovarian Neoplasms/*epidemiology; Prognosis; Risk Factors |
| Abstract |
BACKGROUND: The risk and prognosis of ovarian cancer have not been well established in women with endometriosis. Thus, we investigated the impact of endometriosis on the risk and prognosis for ovarian cancer, and evaluated clinicopathologic characteristics of endometriosis-associated ovarian cancer (EAOC) in comparison with non-EAOC. METHODS: After we searched an electronic search to identify relevant studies published online between January 1990 and December 2012, we found 20 case-control and 15 cohort studies including 444,255 patients from 1,625 potentially relevant studies. In the meta-analysis, ovarian cancer risk by endometriosis and clinicopathologic characteristics were evaluated using risk ratio (RR) or standard incidence ratio (SIR), and prognosis was investigated using hazard ratio (HR) with 95% confidence interval (CI). Heterogeneity was evaluated using Higgins I(2) to select fixed-effect (I(2) </=50%) or random effects models (I(2)>50%), and found no publication bias using funnel plots with Egger's test (P>0.05). Furthermore, we performed subgroup analyses based on study design, assessment of endometriosis, histology, disease status, quality of study and adjustment for potential confounding factors to minimise bias. RESULTS: Endometriosis increased ovarian cancer risk in case-control or two-arm cohort studies (RR, 1.265; 95% CI, 1.214-1.318) and single-arm cohort studies (SIR, 1.797; 95% CI, 1.276-2.531), which were similar in subgroup analyses. Although progression-free survival was not different between EAOC and non-EAOC (HR, 1.023; 95% CI, 0.712-1.470), EAOC was associated with better overall survival than non-EAOC in crude analyses (HR, 0.778; 95% CI, 0.655-0.925). However, progression-free survival and overall survival were not different between the two groups in subgroup analyses. Stage I-II disease, grade 1 disease and nulliparity were more common in EAOC (RRs, 1.959, 1.319 and 1.327; 95% CIs, 1.367-2.807, 1.149-1.514 and 1.245-1.415), whereas probability of optimal debulking surgery was not different between the two groups (RR, 1.403; 95% CI, 0.915-2.152). Furthermore, endometrioid and clear cell carcinomas were more common in EAOC (RRs, 1.759 and 2.606; 95% CIs, 1.551-1.995 and 2.225-3.053), whereas serous carcinoma was less frequent in EAOC than in non-EAOC (RR, 0.733; 95% CI, 0.617-0.871), and there was no difference in the risk of mucinous carcinoma between the two groups (RR, 0.805; 95% CI, 0.584-1.109). These clinicopathologic characteristics were also similar in subgroup analyses. CONCLUSIONS: Endometriosis is strongly associated with the increased risk of ovarian cancer, and EAOC shows favourable characteristics including early-stage disease, low-grade disease and a specific histology such as endometrioid or clear cell carcinoma. However, endometriosis may not affect disease progression after the onset of ovarian cancer. |
| Address |
1] Department of Obstetrics and Gynecology, Seoul National University College of Medicine, 101 Daekak-ro Jongno-gu, Seoul 110-744, Republic of Korea [2] Cancer Research Institute, Seoul National University College of Medicine, Seoul 110-799, Republic of Korea [3] Major in Biomodulation, World Class University, Seoul National University, Seoul 151-742, Republic of Korea |
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0007-0920 |
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PMID:24518590 |
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ref @ user @ |
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53992 |
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