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Author Wang, S.; Qiu, L.; Lang, J.H.; Shen, K.; Huang, H.F.; Pan, L.Y.; Wu, M.; Yang, J.X.; Guo, L.N.
Title Prognostic analysis of endometrioid epithelial ovarian cancer with or without endometriosis: a 12-year cohort study of Chinese patients Type Journal Article
Year 2013 Publication American Journal of Obstetrics and Gynecology Abbreviated Journal Am J Obstet Gynecol
Volume 209 Issue 3 Pages 241.e1-9
Keywords Adult; Aged; Aged, 80 and over; Cohort Studies; Disease-Free Survival; Endometriosis/*complications; Female; Humans; Middle Aged; Neoplasms, Glandular and Epithelial/*mortality/pathology; Ovarian Neoplasms/*mortality/pathology; Prognosis; Proportional Hazards Models; endometrioid epithelial ovarian cancer; endometriosis prognostic factor; survival
Abstract OBJECTIVE: Clinicopathological characteristics and possible prognostic factors among women with endometrioid epithelial ovarian cancer (EEOC) with or without concurrent endometriosis were investigated. STUDY DESIGN: A search of medical charts at Peking Union Medical College Hospital from 2000 through 2012 identified patients with EEOC with or without endometriosis. RESULTS: Of 188 patients with EEOC, concurrent endometriosis was identified in 32 (17.0%). Patients with concurrent endometriosis were approximately 5 years younger, more likely to be premenopausal, more likely to have an early stage of EEOC, and less likely to have high-grade tumors compared to those without endometriosis. The univariate analysis showed that concurrent endometriosis was a significant prognostic factor for disease-free survival, but this association did not remain in the multivariate analysis. CONCLUSION: Women with EEOC and concurrent endometriosis showed distinct characteristics and had longer disease-free survival when compared to those without endometriosis.
Address Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Beijing, PR China
Corporate Author Thesis
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Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
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ISSN 0002-9378 ISBN Medium
Area Expedition Conference
Notes PMID:23702297 Approved no
Call Number (up) ref @ user @ Serial 53998
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Author Terzi, A.; Aktas, I.Y.; Dolgun, A.; Ayhan, A.; Kucukali, T.; Usubutun, A.
Title Early stage epithelial ovarian cancers: a study of morphologic prognostic factors Type Journal Article
Year 2013 Publication Pathology, Research and Practice Abbreviated Journal Pathol Res Pract
Volume 209 Issue 6 Pages 359-364
Keywords Adult; Carcinoma/mortality/*pathology/surgery; Chi-Square Distribution; Cystadenoma/mortality/*pathology/surgery; Disease-Free Survival; Endometriosis/pathology; Female; Hospitals, University; Humans; Kaplan-Meier Estimate; Middle Aged; Mitotic Index; Multivariate Analysis; Neoplasm Grading; Neoplasm Invasiveness; Neoplasm Staging; Neoplasms, Glandular and Epithelial/mortality/*pathology/surgery; Ovarian Neoplasms/mortality/*pathology/surgery; Predictive Value of Tests; Proportional Hazards Models; Risk Factors; Time Factors; Treatment Outcome; Tumor Burden; Turkey
Abstract We intended to reevaluate the morphologic prognostic factors for early-stage ovarian carcinomas. We reviewed 111 patients diagnosed with early-stage ovarian cancer who had undergone primary surgery at Hacettepe Hospital between 1984 and 2001, using diagnostic criteria from the WHO-2003 classification. We applied the Universal grading system suggested by Shimizu/Silverberg and noted FIGO-stage, histotype, tumor size, bilaterality, and endometriosis. These features were compared with each other and survival. The survival analysis was carried out by Kaplan-Meier curves. Of the cases, 52 were reclassified as 'borderline tumor' or 'cystadenoma with borderline foci' and 59 as 'invasive carcinoma'. FIGO-stage and mitotic count were significant for survivals of 59 patients with cancer. Mitotic index was also significant for the probability of metastasis. The patients with stage-II cancer had 5.65 times more risk of recurrence than stage-I cancer. The 5-year overall and disease-free survivals rates were 90.6% and 87.5% for stage-I, 54.7% and 39.3% for stage-II, respectively. Universal grade did not reach statistical significance for survivals but it was related to FIGO-stage significantly. In conclusion, FIGO-stage is the most reliable prognosticator. Although prognostic value of universal grade is not significant, mitotic count may provide important prognostic information for early-stage ovarian carcinomas.
Address Department of Pathology, Baskent University Medical School, Bahcelievler, Ankara, Turkey. aysenterzi@yahoo.co.uk
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0344-0338 ISBN Medium
Area Expedition Conference
Notes PMID:23643734 Approved no
Call Number (up) ref @ user @ Serial 53999
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Author Jiang, W.; Roma, A.A.; Lai, K.; Carver, P.; Xiao, S.-Y.; Liu, X.
Title Endometriosis involving the mucosa of the intestinal tract: a clinicopathologic study of 15 cases Type Journal Article
Year 2013 Publication Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc Abbreviated Journal Mod Pathol
Volume 26 Issue 9 Pages 1270-1278
Keywords Adult; Aged; Biological Markers/analysis; Biopsy; Endometrial Hyperplasia/metabolism/pathology; Endometriosis/complications/metabolism/*pathology/surgery; Female; Humans; Immunohistochemistry; Intestinal Diseases/complications/metabolism/*pathology/surgery; Intestinal Mucosa/chemistry/*pathology/surgery; Metaplasia; Middle Aged; Prognosis; Stromal Cells/chemistry/pathology; Time Factors
Abstract Endometriosis involving the mucosa of the intestines is rare, but may lead to diagnostic pitfalls. We reviewed 15 cases (seven biopsies and eight resections) from 14 patients. The patients' mean age is 48 years (31-66 years). Presenting symptoms included lower gastrointestinal bleeding, pelvic pain, rectal urgency, abdominal mass, and bowel obstruction. In the majority of cases, the lesion was located in the rectum (73%) with the remainder in the sigmoid colon (20%) and ileum (7%). The most common indication for biopsy was a polypoid lesion seen endoscopically (eight cases). For patients who underwent resections, the most common clinical impression was colonic carcinoma (75%), due to mass lesions and stricture as the most common macroscopic findings. Histologically, one case had stromal endometriosis only, but the remaining 14 cases had both endometrial glands and stroma. Epithelial metaplasia was present in all cases, mostly tubal metaplasia (ciliated epithelium). Hybrid glands and replacement of the surface epithelium by endometrial epithelium were also seen. Crypt architectural distortion, cryptitis, and crypt abscesses were seen in some cases, mimicking chronic active colitis or enteritis. A panel of immunohistochemical stains (CK7, CK20, CDX2, and ER) was found to be useful in biopsies with suspected endometriosis demonstrating unusual histology or only containing endometrioid stroma tissue. Vascular involvement by endometriosis was identified in one case. Endometrial hyperplasia (n=2) and cancer (n=1) were also seen in the ectopic tissue. All patients were alive at follow-up (3-216 months, mean 67 months).
Address Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH, USA
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0893-3952 ISBN Medium
Area Expedition Conference
Notes PMID:23579618 Approved no
Call Number (up) ref @ user @ Serial 54000
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Author Melin, A.-S.; Lundholm, C.; Malki, N.; Swahn, M.-L.; Sparen, P.; Bergqvist, A.
Title Hormonal and surgical treatments for endometriosis and risk of epithelial ovarian cancer Type Journal Article
Year 2013 Publication Acta Obstetricia et Gynecologica Scandinavica Abbreviated Journal Acta Obstet Gynecol Scand
Volume 92 Issue 5 Pages 546-554
Keywords Adult; Aged; Case-Control Studies; Endometriosis/complications/drug therapy/*surgery; Female; Hormones/therapeutic use; Humans; Middle Aged; Neoplasms, Glandular and Epithelial/*epidemiology/etiology; Odds Ratio; Ovarian Neoplasms/*epidemiology/etiology; Ovariectomy/methods; Registries; Risk Assessment; Sweden/epidemiology; Young Adult
Abstract OBJECTIVE: Whether hormonal or surgical treatment of endometriosis is associated with risk of epithelial ovarian cancer. DESIGN: Nested case-control study. SETTING: Sweden. POPULATION: All women with a first-time discharge diagnosis of endometriosis in 1969-2007 were identified using the National Swedish Patient Register and constituted our study base. METHODS: By linkage to the National Swedish Cancer Register we identified all women diagnosed with epithelial ovarian cancer at least one year after the endometriosis diagnosis (cases). Two controls per case with no ovarian cancer before the date of cancer diagnosis of the case were randomly selected from the study base and matched for year of birth. Two-hundred-and-twenty cases and 416 controls entered the study. Information on hormonal and surgical treatments and other reproductive factors was extracted from medical records according to pre-specified protocols. Conditional logistic regression was used for all calculations. MAIN OUTCOME MEASURES: Crude and adjusted odds ratios (OR) with 95% confidence intervals (CI) for all hormonal as well as surgical treatments. RESULTS: There was a significant association between one-sided oophorectomy, as well as for radical extirpation of all visible endometriosis, and ovarian cancer risk in both univariate analyses (crude OR 0.42, 95% CI 0.28-0.62 and OR 0.37, 95% CI 0.25-0.55, respectively) and multivariate analyses (adjusted OR 0.19, 95% CI 0.08-0.46 and OR 0.30, 95% CI 0.12-0.74, respectively). CONCLUSIONS: One-sided oophorectomy as well as radical extirpation of all visible endometriosis is protective against later development of ovarian cancer.
Address Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden. anna-sofia.melin@aleris.se
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0001-6349 ISBN Medium
Area Expedition Conference
Notes PMID:23560387 Approved no
Call Number (up) ref @ user @ Serial 54001
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Author Van Le, L.; Jackson, A.; Schuler, K.; Suri, A.; Doll, K.; Stine, J.; Kim, K.
Title Discussion: 'Ovarian epithelial carcinoma with pelvic endometriosis,' by Wang et al Type Journal Article
Year 2013 Publication American Journal of Obstetrics and Gynecology Abbreviated Journal Am J Obstet Gynecol
Volume 208 Issue 5 Pages e1-2
Keywords Endometriosis/*complications; Female; Humans; Neoplasms, Glandular and Epithelial/*etiology; Ovarian Neoplasms/*etiology
Abstract In the roundtable that follows, clinicians discuss a study published in this issue of the Journal in light of its methodology, relevance to practice, and implications for future research. Article discussed: Wang S, Qui L, Lang JH, et al. Clinical analysis of ovarian epithelial carcinoma with coexisting pelvic endometriosis.
Address Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0002-9378 ISBN Medium
Area Expedition Conference
Notes PMID:23500450 Approved no
Call Number (up) ref @ user @ Serial 54002
Permanent link to this record