| Records |
| Author |
Wang, S.; Qiu, L.; Lang, J.H.; Shen, K.; Yang, J.X.; Huang, H.F.; Pan, L.Y.; Wu, M. |
| Title |
Clinical analysis of ovarian epithelial carcinoma with coexisting pelvic endometriosis |
Type |
Journal Article |
| Year |
2013 |
Publication |
American Journal of Obstetrics and Gynecology |
Abbreviated Journal |
Am J Obstet Gynecol |
| Volume |
208 |
Issue |
5 |
Pages |
413.e1-5 |
| Keywords |
Adolescent; Adult; Age Factors; Aged; CA-125 Antigen/blood; Endometriosis/*complications; Female; Humans; Middle Aged; Neoplasm Staging; Neoplasms, Glandular and Epithelial/blood/*etiology/pathology; Ovarian Neoplasms/blood/*etiology/pathology; Retrospective Studies; Risk Factors; Young Adult |
| Abstract |
OBJECTIVES: To explore the differences between women with endometriosis associated ovarian cancer and typical epithelial ovarian cancer. STUDY DESIGN: The medical charts of total 226 patients with epithelial ovarian cancer treated at Peking Union Medical College Hospital between March 2011 and March 2012 were reviewed. Histology evaluation determined endometriosis associated ovarian cancer (n = 17) or non-endometriosis associated ovarian cancer (n = 209). RESULTS: Compared with non-endometriosis associated ovarian cancer, patients with endometriosis associated ovarian cancer were proved: (1) to be younger and more likely to be premenopausal at diagnosis of epithelial ovarian cancer (P = .03 and .005, respectively); (2) to have lower preoperative serum level of Ca125 (mean: 122.9 vs 1377.5 U/mL, P < .001) and more likely to display normal Ca125 level (P < .001); (3) to be identified at the earlier stage (stage I, P < .001); (4) to have completely different distribution of histological subtypes (significant overrepresentation of clear cell and endometrioid carcinoma). CONCLUSION: As such, patients with endometriosis associated ovarian cancer differ from non-endomertiosis associated ovarian cancer in many of their critical clinical and biologic characteristics. |
| Address |
Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Beijing, P.R. China. wangshu219@hotmail.com |
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English |
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0002-9378 |
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| Notes |
PMID:23220508 |
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no |
Call Number  |
ref @ user @ |
Serial |
54008 |
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| Author |
Stewart, L.M.; Holman, C.D.'A.J.; Aboagye-Sarfo, P.; Finn, J.C.; Preen, D.B.; Hart, R. |
| Title |
In vitro fertilization, endometriosis, nulliparity and ovarian cancer risk |
Type |
Journal Article |
| Year |
2013 |
Publication |
Gynecologic Oncology |
Abbreviated Journal |
Gynecol Oncol |
| Volume |
128 |
Issue |
2 |
Pages |
260-264 |
| Keywords |
Adult; Cohort Studies; Endometriosis/*epidemiology; Female; Fertilization in Vitro/*statistics & numerical data; Humans; Hysterectomy/statistics & numerical data; Infertility, Female/epidemiology; Middle Aged; Neoplasms, Glandular and Epithelial/*epidemiology; Ovarian Neoplasms/*epidemiology; Ovariectomy/statistics & numerical data; Parity; Registries; Risk Factors; Western Australia/epidemiology |
| Abstract |
OBJECTIVES: To examine the risk of invasive epithelial ovarian cancer in a cohort of women seeking treatment for infertility. METHODS: Using whole-population linked hospital and registry data, we conducted a cohort study of 21,646 women commencing hospital investigation and treatment for infertility in Western Australia in the years 1982-2002. We examined the effects of IVF treatment, endometriosis and parity on risk of ovarian cancer and explored potential confounding by tubal ligation, hysterectomy and unilateral oophorectomy/salpingo-oophorectomy (USO). RESULTS: Parous women undergoing IVF had no observable increase in the rate of ovarian cancer (hazard ratio [HR] 1.01; 95% confidence interval [CI] 0.35-2.90); the HR in women who had IVF and remained nulliparous was 1.76 (95% CI 0.74-4.16). Women diagnosed with endometriosis who remained nulliparous had a three-fold increase in the rate of ovarian cancer (HR 3.11; 95% CI 1.13-8.57); the HR in parous women was 1.52 (95% CI 0.34-6.75). In separate analyses, women who had a USO without hysterectomy had a four-fold increase in the rate of ovarian cancer (HR 4.23; 95% CI 1.30-13.77). Hysterectomy with or without USO appeared protective. CONCLUSIONS: There is no evidence of an increased risk of ovarian cancer following IVF in women who give birth. There is some uncertainty regarding the effect of IVF in women who remain nulliparous. Parous women diagnosed with endometriosis may have a slightly increased risk of ovarian cancer; nulliparous women have a marked increase in risk. |
| Address |
School of Population Health, Faculty of Medicine, Dentistry and Health Sciences, The University of Western Australia, M431, 35 Stirling Highway, Crawley, WA 6009, Australia. louise.stewart@uwa.edu.au |
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0090-8258 |
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| Notes |
PMID:23116937 |
Approved |
no |
| Call Number |
ref @ user @ |
Serial |
54009 |
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Shalin, S.C.; Haws, A.L.; Carter, D.G.; Zarrin-Khameh, N. |
| Title |
Clear cell adenocarcinoma arising from endometriosis in abdominal wall cesarean section scar: a case report and review of the literature |
Type |
Journal Article |
| Year |
2012 |
Publication |
Journal of Cutaneous Pathology |
Abbreviated Journal |
J Cutan Pathol |
| Volume |
39 |
Issue |
11 |
Pages |
1035-1041 |
| Keywords |
*Adenocarcinoma, Clear Cell/etiology/pathology; *Cesarean Section; *Cicatrix/complications/pathology; *Endometriosis/complications/pathology; Female; Humans; Middle Aged; Postoperative Complications/*pathology; *Skin Neoplasms/etiology/pathology |
| Abstract |
Malignancy arising in association with endometriosis is a rare but well-documented phenomenon that was first described in the literature as early as 1925. Cutaneous endometriosis with subsequent malignant transformation is even more uncommon, and high clinical suspicion is required for diagnosis. The clinical differential diagnosis of these lesions includes a wide variety of entities, ranging from benign cysts to malignancies such as melanoma. We report a case of clear cell adenocarcinoma arising from endometriosis in a cesarean section scar in a 47-year-old woman, and we complete a review of the literature regarding this unusual entity. |
| Address |
Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA |
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English |
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0303-6987 |
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| Notes |
PMID:22882475 |
Approved |
no |
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ref @ user @ |
Serial |
54010 |
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Zygouris, D.; Leontara, V.; Makris, G.M.; Chrelias, C.; Trakakis, E.; Christodoulaki, C.; Panagopoulos, P. |
| Title |
Endometrioid ovarian cancer arising from an endometriotic cyst in a young patient |
Type |
Journal Article |
| Year |
2012 |
Publication |
European Journal of Gynaecological Oncology |
Abbreviated Journal |
Eur J Gynaecol Oncol |
| Volume |
33 |
Issue |
3 |
Pages |
324-325 |
| Keywords |
Adnexal Diseases/surgery; Adult; Carcinoma, Endometrioid/drug therapy/etiology/*surgery; Chemotherapy, Adjuvant; Endometriosis/complications/surgery; Female; Humans; Ovarian Cysts/complications/*surgery; Ovarian Neoplasms/drug therapy/etiology/*surgery |
| Abstract |
OBJECTIVE: To present a case of a young woman with ovarian endometrioid adenocarcinoma arising from an endometriotic cyst and review of the literature. CASE REPORT: A 33-year-old woman, gravid 2, para 2 was admitted to our department with a 5 cm adnexal mass. Diagnostic laparoscopy was performed and pathological examination demonstrated an endometriotic cyst with an area of an ovarian endometrioid adenocarcinoma well differentiated, with no capsular invasion. One month after the operation the patient underwent MRI which revealed a 6 cm mass in the Douglas pouch. The multidisciplinary oncology council decided on exploratory laparotomy, which revealed no pathology. After that the multidisciplinary oncology council decided on adjuvant chemotherapy and the patient received four cycles of carboplatin/taxol. CONCLUSION: It should always be considered that even when there are no risk factors for malignancy occurrence, a high index of suspicion is necessary and will help to prevent delay in the diagnosis of this rare neoplasm. |
| Address |
3rd Deptartment of Obstetrics & Gynaecology University of Athens, Greece |
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English |
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0392-2936 |
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| Notes |
PMID:22873112 |
Approved |
no |
| Call Number |
ref @ user @ |
Serial |
54011 |
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| Author |
Morotti, M.; Remorgida, V.; Venturini, P.L.; Ferrero, S. |
| Title |
Endometriosis in menopause: a single institution experience |
Type |
Journal Article |
| Year |
2012 |
Publication |
Archives of Gynecology and Obstetrics |
Abbreviated Journal |
Arch Gynecol Obstet |
| Volume |
286 |
Issue |
6 |
Pages |
1571-1575 |
| Keywords |
Abdominal Pain/etiology; Aged; Appendiceal Neoplasms/pathology/surgery; Asymptomatic Diseases; Carcinoma/pathology/surgery; Chi-Square Distribution; Diagnosis, Differential; Endometriosis/complications/*pathology/surgery; Estrogen Replacement Therapy; Female; Humans; Hyperplasia; Incidental Findings; Middle Aged; Ovarian Cysts/complications/diagnosis/surgery; Ovarian Neoplasms/*pathology/surgery; Peritoneal Neoplasms/*pathology/surgery; *Postmenopause; Rectal Neoplasms/pathology/surgery; Retrospective Studies; Uterine Hemorrhage/etiology; Vaginal Neoplasms/pathology/surgery |
| Abstract |
PURPOSE: This study aims to present the clinical characteristics of a series of postmenopausal women with endometriosis and to evaluate the preferential location, extension and histopathological features of the lesions. METHODS: We retrospectively examined the clinical records of 72 postmenopausal women with endometriosis who underwent surgery between January 1998 and December 2010. RESULTS: The median age of patients at the time of surgery was 58.5 years. Eleven patients (15.3%) had previous history of endometriosis and five patients had previously undergone surgery for this reason. Only two patients included in the study were using hormone replacement therapy at the time of surgery. The most frequent location of endometriotic lesions was the ovary and among patients with endometriomas, 35% (20/57) had different grades of metaplasia, hyperplasia, atypia and endometrioid carcinoma arising in endometriosis. The proportions of epithelium, stroma and hemorrhage in endometriotic lesions were higher in patients with concomitant endometrial or ovarian cancer. CONCLUSIONS: Endometriosis should be considered in the differential diagnosis of postmenopausal cystic lesions of the ovary. The administration of exogenous estrogen is not a prerequisite for the presence of endometriosis in postmenopausal women, and histological signs of functionally active lesions were also observed in the absence of exogenous hormone intake. |
| Address |
Department of Obstetrics and Gynecology, San Martino Hospital and University of Genoa, Largo R. Benzi 1, 16132, Genoa, Italy. dottmatteomorotti@libero.it |
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English |
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0932-0067 |
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| Notes |
PMID:22825693 |
Approved |
no |
| Call Number |
ref @ user @ |
Serial |
54012 |
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