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Author Ho, R.S.L.; Chan, G.C.F.; Ha, S.Y.; Ip, P.P.C. url  doi
openurl 
  Title Endometriosis-associated serous borderline tumor and endometrial stromal sarcoma of the ovary: a report of a rare lesion in an infant Type Journal Article
  Year 2012 Publication International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists Abbreviated Journal Int J Gynecol Pathol  
  Volume 31 Issue 1 Pages 98-102  
  Keywords Cystadenocarcinoma, Serous/complications/*pathology/surgery; Endometrial Neoplasms/complications/*pathology/surgery; Endometriosis/complications/*pathology/surgery; Epithelial Cells/pathology; Female; Follow-Up Studies; Humans; Immunohistochemistry; Incidental Findings; Infant; Neprilysin/metabolism; Ovarian Cysts/*pathology; Ovarian Neoplasms/complications/*pathology/surgery; Ovary/pathology; Sarcoma, Endometrial Stromal/complications/*pathology/surgery; Stromal Cells/pathology  
  Abstract Endometriosis in infancy is most unusual, and associated tumors in this age group are exceptionally rare. We report a case of a serous borderline tumor and endometrial stromal sarcoma arising in an ovarian endometriotic cyst. The patient was an infant of 18 months of age who presented with an incidental abdominal mass. The serum sex hormones were at prepubertal levels. There was no evidence of precocious puberty or any obvious genital anomaly. Intraoperative findings included a solitary solid and multicystic right ovarian mass without evidence of any extraovarian disease. On microscopic examination, the tumor was composed of an intimate mixture of florid papillary and stromal cell proliferation in the wall of an endometriotic cyst. The papillae showed hierarchical branching and had hyalinized and edematous cores with scattered psammoma bodies. The epithelial cells were mildly atypical and mitotically inactive. The underlying endometrial stromal cells were arranged in irregular tongues that permeated the thickened fibrous cyst wall. They were mitotically active and immunoreactive for CD10. There was no evidence of any primitive germ cell tumor. The patient received no adjuvant treatment and had an uneventful postoperative follow-up period of 30 months. To the best of our knowledge, endometriosis associated with this most unusual combination of ovarian tumors has never been reported in an infant.  
  Address Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0277-1691 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:22123729 Approved no  
  Call Number (up) ref @ user @ Serial 54028  
Permanent link to this record
 

 
Author Wang, T.T.; Jabbour, R.J.; Girling, J.C.; McDonald, P.J. url  doi
openurl 
  Title Extraluminal bowel obstruction by endometrioid adenocarcinoma 34 years post-hysterectomy: risks of unopposed oestrogen therapy Type Journal Article
  Year 2011 Publication Journal of the Royal Society of Medicine Abbreviated Journal J R Soc Med  
  Volume 104 Issue 10 Pages 421-423  
  Keywords Aged; Carcinoma, Endometrioid/*etiology/radiography; Endometriosis/*complications/surgery; Estrogen Replacement Therapy/*adverse effects; Estrogens/*adverse effects; Female; Humans; *Hysterectomy; Intestinal Neoplasms/radiography/secondary; Intestinal Obstruction/*etiology; *Ovariectomy; Postoperative Complications; Risk Factors  
  Abstract  
  Address Department of General Surgery, Northwick Park & St Mark's Hospitals, Harrow, UK. tim.wang04@imperial.ac.uk  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0141-0768 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:21969480 Approved no  
  Call Number (up) ref @ user @ Serial 54029  
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Author Boes, A.S.; Tousseyn, T.; Vandenput, I.; Timmerman, D.; Vergote, I.; Moerman, P.; Amant, F. url  openurl
  Title Pitfall in the diagnosis of endometrial cancer: case report of an endometrioid adenocarcinoma arising from uterine adenomyosis Type Journal Article
  Year 2011 Publication European Journal of Gynaecological Oncology Abbreviated Journal Eur J Gynaecol Oncol  
  Volume 32 Issue 4 Pages 431-434  
  Keywords Carcinoma, Endometrioid/diagnosis/etiology/*pathology; Delayed Diagnosis; Endometrial Neoplasms/diagnosis/etiology/*pathology; Endometriosis/complications/diagnosis/*pathology; Female; Humans; Middle Aged; Neoplasms, Second Primary/diagnosis/etiology/*pathology; Uterine Neoplasms/diagnosis/etiology/*pathology  
  Abstract BACKGROUND: The development of cancer from adenomyotic foci is a rare occurrence. The diagnosis is frequently delayed because of the absence of tumor in the eutopic endometrium. CASE REPORT: We present a case of a 64-year-old postmenopausal woman with irregular vaginal bleeding and dull abdominal pain. Hysteroscopy was negative and hormonal treatment was continued. Nine months later, persisting symptoms necessitated endometrial biopsy revealing an atrophic endometrium. Hydrosonography suggested an endometrial polyp of 14 x 7 mm with a surrounding regular thin endometrium and a diffusely inhomogeneous ultrasonographic pattern throughout the myometrium. Hysteroscopic excision of the endometrial polyp was performed. Biopsies obtained during operative hysteroscopy showed a well differentiated endometrioid endometrial carcinoma. A laparoscopically assisted vaginal hysterectomy with bilateral salpingo-oophorectomy, pelvic lymphadenectomy and peritoneal cytology was performed. Pathologic examination revealed an atrophic endometrium and a Stage IB (FIGO 2009) well differentiated endometrioid endometrial carcinoma with prominent squamous differentiation originating from nodular adenomyosis. This ectopic localization of the endometrioid carcinoma added to a diagnostic delay of 12 months. CONCLUSION: Endometrial cancer arising from uterine adenomyosis may be difficult to diagnose. Awareness of this entity and careful ultrasonography are likely to reduce diagnostic delay.  
  Address Department of Obstetrics and Gynecology, UZ Gasthuisberg, Katholieke Universiteit, Leuven, Belgium  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0392-2936 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:21941970 Approved no  
  Call Number (up) ref @ user @ Serial 54030  
Permanent link to this record
 

 
Author Haruta, S.; Furukawa, N.; Yoshizawa, Y.; Tsunemi, T.; Nagai, A.; Kawaguchi, R.; Tanase, Y.; Yoshida, S.; Kobayashi, H. url  doi
openurl 
  Title Molecular genetics and epidemiology of epithelial ovarian cancer (Review) Type Journal Article
  Year 2011 Publication Oncology Reports Abbreviated Journal Oncol Rep  
  Volume 26 Issue 6 Pages 1347-1356  
  Keywords Diet, High-Fat/adverse effects; Endometriosis/complications; Female; Genes, Neoplasm; Hormone Replacement Therapy/adverse effects; Humans; Incidence; Neoplasms, Glandular and Epithelial/*epidemiology/etiology/*genetics; Ovarian Neoplasms/*epidemiology/etiology/*genetics; Risk Factors  
  Abstract This review summarizes data from recent molecular genetic and epidemiology studies of the generic term 'female pelvic cancer'. The English-language literature was reviewed for genetic, epigenetic, epidemiologic and environmental risk factors. There are well-documented disparities among racial and ethnic groups with respect to epithelial ovarian cancer (EOC) prevalence. In the case of the serous histological subtype, primary EOC, fallopian tube cancer and peritoneal cancer could be regarded as a single disease entity. However, EOC is not a single disease. Comparing the profile of EOC between Japanese and Caucasians, clear cell carcinomas (27.6%) are more common in Japan, possibly with fewer serous adenocarcinomas (40.7%). This may reflect a proportional increase. The Japanese may exhibit a higher proportion of malignant transformation of endometriosis compared to the United States population. Although some part of the molecular genetic pathogenesis has been unveiled, the complete events of molecular genetic epidemiological changes associated with EOC remain to be identified. This review focuses on current knowledge of the genetic and environmental factors affecting the development of EOC, and outlines future challenges in its pathogenesis research.  
  Address Department of Obstetrics and Gynecology, Nara Medical University, Nara 634-8522, Japan  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1021-335X ISBN Medium  
  Area Expedition Conference  
  Notes PMID:21922146 Approved no  
  Call Number (up) ref @ user @ Serial 54031  
Permanent link to this record
 

 
Author Yamada, Y.; Shigetomi, H.; Onogi, A.; Haruta, S.; Kawaguchi, R.; Yoshida, S.; Furukawa, N.; Nagai, A.; Tanase, Y.; Tsunemi, T.; Oi, H.; Kobayashi, H. url  doi
openurl 
  Title Redox-active iron-induced oxidative stress in the pathogenesis of clear cell carcinoma of the ovary Type Journal Article
  Year 2011 Publication International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society Abbreviated Journal Int J Gynecol Cancer  
  Volume 21 Issue 7 Pages 1200-1207  
  Keywords Adenocarcinoma, Clear Cell/*etiology/metabolism/physiopathology; Animals; Cell Transformation, Neoplastic; Endometriosis/*complications/metabolism; Female; Humans; Iron/*metabolism; Ovarian Neoplasms/*etiology/metabolism/physiopathology; *Oxidative Stress; Reactive Oxygen Species/metabolism  
  Abstract OBJECTIVE: Epithelial ovarian cancer (EOC) is the most lethal pelvic gynecologic cancer. Clear cell carcinoma (CCC) and endometrioid adenocarcinoma (EAC) of the ovary have been associated with endometriosis, thus indicating that endometriosis has been believed to increase the risk of developing EOC. The aim of our review was to identify and synthesize the most current information on CCC with regard to molecular and pathophysiological distinctions. METHOD: This article reviews the English-language literature for molecular, pathogenetic, and pathophysiological studies on endometriosis and endometriosis-associated ovarian cancer (EAOC). In this review, we focus on the functions and roles of redox-active iron in CCC carcinogenesis. RESULTS: The iron-induced reactive oxygen species signals can contribute to carcinogenesis via 3 major processes: step 1, by increasing oxidative stress, which promotes DNA mutagenesis, histone modification, chromatin remodeling, and gene products activation/inactivation thus contributing to EAOC initiation; step 2, by activating detoxification and antiapoptotic pathways via the transcription factor hepatocyte nuclear factor 1beta overexpression, thereby contributing to CCC promotion; and step 3, by creating an environment that supports sustained growth, angiogenesis, migration, and invasion of cancer cells via estrogen-dependent (EAC) or estrogen-independent (CCC) mechanisms, thus supporting tumor progression and metastasis. CONCLUSIONS: These aspects of reactive oxygen species biology will be discussed in the context of its relationship to EAOC carcinogenesis.  
  Address Department of Obstetrics and Gynecology, Nara Medical University, Nara, Japan  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1048-891X ISBN Medium  
  Area Expedition Conference  
  Notes PMID:21885986 Approved no  
  Call Number (up) ref @ user @ Serial 54032  
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