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Author Teofili, L.; Bianchi, M.; Zanfini, B.A.; Catarci, S.; Sicuranza, R.; Spartano, S.; Zini, G.; Draisci, G.
Title Acute lung injury complicating blood transfusion in post-partum hemorrhage: incidence and risk factors Type Journal Article
Year 2014 Publication Mediterranean Journal of Hematology and Infectious Diseases Abbreviated Journal Mediterr J Hematol Infect Dis
Volume 6 Issue 1 Pages (down) e2014069
Keywords
Abstract BACKGROUND: We retrospectively investigated the incidence and risk factors for transfusion-related acute lung injury (TRALI) among patients transfused for post-partum hemorrhage (PPH). METHODS: We identified a series of 71 consecutive patients with PPH requiring the urgent transfusion of three or more red blood cell (RBC) units, with or without transfusion of fresh frozen plasma (FFP) and/or platelets (PLT). Clinical records were then retrieved and examined for respiratory distress events. According to the 2004 consensus definition, cases of new-onset hypoxemia, within 6 hours after transfusion, with bilateral pulmonary changes, in the absence of cardiogenic pulmonary edema were identified as TRALI. If an alternative risk factor for acute lung injury was present, possible TRALI was diagnosed. RESULTS: Thirteen cases of TRALI and 1 case of possible TRALI were identified (overall incidence 19.7%). At univariate analysis, patients with TRALI received higher number of RBC, PLT and FFP units and had a longer postpartum hospitalization. Among the diseases occurring in pregnancy- and various pre-existing comorbidities, only gestational hypertension and pre-eclampsia, significantly increased the risk to develop TRALI (p = 0.006). At multivariate analysis including both transfusion- and patient-related risk factors, pregnancy-related, hypertensive disorders were confirmed to be the only predictors for TRALI, with an odds ratio of 27.7 ( 95% CI 1.27-604.3, p=0.034). CONCLUSIONS: Patients suffering from PPH represent a high-risk population for TRALI. The patients with gestational hypertension and pre-eclampsia, not receiving anti-hypertensive therapy, have the highest risk. Therefore, a careful monitoring of these patients after transfusions is recommended.
Address Anesthesiology Department, Universita Cattolica del Sacro Cuore, Rome, Italy
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 2035-3006 ISBN Medium
Area Expedition Conference
Notes PMID:25408855 Approved no
Call Number ref @ user @ Serial 62233
Permanent link to this record
 

 
Author Teofili, L.; Bianchi, M.; Zanfini, B.A.; Catarci, S.; Sicuranza, R.; Spartano, S.; Zini, G.; Draisci, G.
Title Acute lung injury complicating blood transfusion in post-partum hemorrhage: incidence and risk factors Type Journal Article
Year 2014 Publication Mediterranean Journal of Hematology and Infectious Diseases Abbreviated Journal Mediterr J Hematol Infect Dis
Volume 6 Issue 1 Pages (down) e2014069
Keywords
Abstract BACKGROUND: We retrospectively investigated the incidence and risk factors for transfusion-related acute lung injury (TRALI) among patients transfused for post-partum hemorrhage (PPH). METHODS: We identified a series of 71 consecutive patients with PPH requiring the urgent transfusion of three or more red blood cell (RBC) units, with or without transfusion of fresh frozen plasma (FFP) and/or platelets (PLT). Clinical records were then retrieved and examined for respiratory distress events. According to the 2004 consensus definition, cases of new-onset hypoxemia, within 6 hours after transfusion, with bilateral pulmonary changes, in the absence of cardiogenic pulmonary edema were identified as TRALI. If an alternative risk factor for acute lung injury was present, possible TRALI was diagnosed. RESULTS: Thirteen cases of TRALI and 1 case of possible TRALI were identified (overall incidence 19.7%). At univariate analysis, patients with TRALI received higher number of RBC, PLT and FFP units and had a longer postpartum hospitalization. Among the diseases occurring in pregnancy- and various pre-existing comorbidities, only gestational hypertension and pre-eclampsia, significantly increased the risk to develop TRALI (p = 0.006). At multivariate analysis including both transfusion- and patient-related risk factors, pregnancy-related, hypertensive disorders were confirmed to be the only predictors for TRALI, with an odds ratio of 27.7 ( 95% CI 1.27-604.3, p=0.034). CONCLUSIONS: Patients suffering from PPH represent a high-risk population for TRALI. The patients with gestational hypertension and pre-eclampsia, not receiving anti-hypertensive therapy, have the highest risk. Therefore, a careful monitoring of these patients after transfusions is recommended.
Address Anesthesiology Department, Universita Cattolica del Sacro Cuore, Rome, Italy
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 2035-3006 ISBN Medium
Area Expedition Conference
Notes PMID:25408855 Approved no
Call Number ref @ user @ Serial 63417
Permanent link to this record
 

 
Author Teofili, L.; Bianchi, M.; Zanfini, B.A.; Catarci, S.; Sicuranza, R.; Spartano, S.; Zini, G.; Draisci, G.
Title Acute lung injury complicating blood transfusion in post-partum hemorrhage: incidence and risk factors Type Journal Article
Year 2014 Publication Mediterranean Journal of Hematology and Infectious Diseases Abbreviated Journal Mediterr J Hematol Infect Dis
Volume 6 Issue 1 Pages (down) e2014069
Keywords
Abstract BACKGROUND: We retrospectively investigated the incidence and risk factors for transfusion-related acute lung injury (TRALI) among patients transfused for post-partum hemorrhage (PPH). METHODS: We identified a series of 71 consecutive patients with PPH requiring the urgent transfusion of three or more red blood cell (RBC) units, with or without transfusion of fresh frozen plasma (FFP) and/or platelets (PLT). Clinical records were then retrieved and examined for respiratory distress events. According to the 2004 consensus definition, cases of new-onset hypoxemia, within 6 hours after transfusion, with bilateral pulmonary changes, in the absence of cardiogenic pulmonary edema were identified as TRALI. If an alternative risk factor for acute lung injury was present, possible TRALI was diagnosed. RESULTS: Thirteen cases of TRALI and 1 case of possible TRALI were identified (overall incidence 19.7%). At univariate analysis, patients with TRALI received higher number of RBC, PLT and FFP units and had a longer postpartum hospitalization. Among the diseases occurring in pregnancy- and various pre-existing comorbidities, only gestational hypertension and pre-eclampsia, significantly increased the risk to develop TRALI (p = 0.006). At multivariate analysis including both transfusion- and patient-related risk factors, pregnancy-related, hypertensive disorders were confirmed to be the only predictors for TRALI, with an odds ratio of 27.7 ( 95% CI 1.27-604.3, p=0.034). CONCLUSIONS: Patients suffering from PPH represent a high-risk population for TRALI. The patients with gestational hypertension and pre-eclampsia, not receiving anti-hypertensive therapy, have the highest risk. Therefore, a careful monitoring of these patients after transfusions is recommended.
Address Anesthesiology Department, Universita Cattolica del Sacro Cuore, Rome, Italy
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 2035-3006 ISBN Medium
Area Expedition Conference
Notes PMID:25408855 Approved no
Call Number ref @ user @ Serial 64085
Permanent link to this record
 

 
Author Teofili, L.; Bianchi, M.; Zanfini, B.A.; Catarci, S.; Sicuranza, R.; Spartano, S.; Zini, G.; Draisci, G.
Title Acute lung injury complicating blood transfusion in post-partum hemorrhage: incidence and risk factors Type Journal Article
Year 2014 Publication Mediterranean Journal of Hematology and Infectious Diseases Abbreviated Journal Mediterr J Hematol Infect Dis
Volume 6 Issue 1 Pages (down) e2014069
Keywords
Abstract BACKGROUND: We retrospectively investigated the incidence and risk factors for transfusion-related acute lung injury (TRALI) among patients transfused for post-partum hemorrhage (PPH). METHODS: We identified a series of 71 consecutive patients with PPH requiring the urgent transfusion of three or more red blood cell (RBC) units, with or without transfusion of fresh frozen plasma (FFP) and/or platelets (PLT). Clinical records were then retrieved and examined for respiratory distress events. According to the 2004 consensus definition, cases of new-onset hypoxemia, within 6 hours after transfusion, with bilateral pulmonary changes, in the absence of cardiogenic pulmonary edema were identified as TRALI. If an alternative risk factor for acute lung injury was present, possible TRALI was diagnosed. RESULTS: Thirteen cases of TRALI and 1 case of possible TRALI were identified (overall incidence 19.7%). At univariate analysis, patients with TRALI received higher number of RBC, PLT and FFP units and had a longer postpartum hospitalization. Among the diseases occurring in pregnancy- and various pre-existing comorbidities, only gestational hypertension and pre-eclampsia, significantly increased the risk to develop TRALI (p = 0.006). At multivariate analysis including both transfusion- and patient-related risk factors, pregnancy-related, hypertensive disorders were confirmed to be the only predictors for TRALI, with an odds ratio of 27.7 ( 95% CI 1.27-604.3, p=0.034). CONCLUSIONS: Patients suffering from PPH represent a high-risk population for TRALI. The patients with gestational hypertension and pre-eclampsia, not receiving anti-hypertensive therapy, have the highest risk. Therefore, a careful monitoring of these patients after transfusions is recommended.
Address Anesthesiology Department, Universita Cattolica del Sacro Cuore, Rome, Italy
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 2035-3006 ISBN Medium
Area Expedition Conference
Notes PMID:25408855 Approved no
Call Number ref @ user @ Serial 64428
Permanent link to this record
 

 
Author Capria, S.; De Angelis, F.; Gentile, G.; Trisolini, S.M.; Brocchieri, S.; Canichella, M.; Chiusolo, P.; Micozzi, A.; Foa, R.; Meloni, G.
Title Complete remission obtained with azacitidine in a patient with concomitant therapy related myeloid neoplasm and pulmonary mucormycosis Type Journal Article
Year 2013 Publication Mediterranean Journal of Hematology and Infectious Diseases Abbreviated Journal Mediterr J Hematol Infect Dis
Volume 5 Issue 1 Pages (down) e2013048
Keywords
Abstract Mucormycosis is the third cause of invasive mycosis after candidiasis and aspergillosis in AML patients, representing a poor prognostic factor associated with a high rate of fatal outcome. We report a case of a patient with AML and a concomitant pulmonary mucormycosis at diagnosis, who obtained a complete remission both of her AML and of the fungal infection. The incidence of the infection at the onset of leukemia is extremely unusual, and, to our knowledge, the sporadic cases reported in the literature are included in heterogeneous series retrospectively examined. In our case, Liposomal Amphotericin B as single agent appeared incapable of controlling the infection, so anti-infective therapy was intensified with posaconazole and simultaneously antileukemic treatment with 5-azacitidine was started, with the understanding that the only antifungal treatment would not have been able to keep the infection under control for a long time if not associated with a reversal of neutropenia related to the disease. We observed a progressive improvement of the general conditions, a healing of pneumonia and a complete remission of the leukemic disease, suggesting that a careful utilization of the new compounds available today, in terms of both antifungal and antileukemic treatment, may offer a curative chance a patient who would have otherwise been considered unfit for a potentially curative therapeutic strategy.
Address Department of Cellular Biotechnologies and Hematology, “Sapienza” University of Rome, Rome, Italy
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 2035-3006 ISBN Medium
Area Expedition Conference
Notes PMID:23936619 Approved no
Call Number refbase @ user @ Serial 23581
Permanent link to this record