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Author Uhlmann, G.
Title Electrical Impedance tomography and Calderóns problem Type Journal Article
Year 2009 Publication Inverse Problems Abbreviated Journal
Volume 25 Issue Pages (down) 1230011-1230039
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Call Number ref @ user @ Uhlma2009 Serial 86214
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Author Smith, A.W.; Parashar, B.; Wernicke, A.G.
Title Subventricular zone-associated glioblastoma: A call for translational research to guide clinical decision making Type Journal Article
Year 2016 Publication Neurogenesis (Austin, Tex.) Abbreviated Journal Neurogenesis (Austin)
Volume 3 Issue 1 Pages (down) e1225548
Keywords cancer stem cells; glioblastoma; neural stem cells; radiation; subventricular zone
Abstract Glioblastoma (GBM) is both the most common and the most devastating primary cancer of the central nervous system, with an expected overall survival in most patients of about 14 months. Despite extensive research, outcomes for GBM have been largely unchanged since the introduction of temozolomide in 2005. We believe that in order to achieve a breakthrough in therapeutic management, we must begin to identify subtypes of GBM, and tailor treatment to best target a particular tumor's vulnerabilities. Our group has recently produced an examination of the clinical outcomes of radiation therapy directed at tumors that contact the subventricular zone (SVZ), the 3-5 mm lateral border of the lateral ventricles that contains the largest collection of neural stem cells in the adult brain. We find that SVZ-associated tumors have worse progression free and overall survival than tumors that do not contact the SVZ, and that they exhibit unique recurrence and migration patterns. However, with minimal basic science research into SVZ-associated GBM, it is currently impossible to determine if the clinicobehavioral uniqueness of this group of tumors represents a true disease subtype from a genetic perspective. We believe that further translational research into SVZ-associated GBM is needed to establish a therapeutic profile.
Address Stitch Radiation Oncology, Weill-Cornell Medical College/New York Presbyterian Hospital , New York, NY, USA
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ISSN 2326-2133 ISBN Medium
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Notes PMID:27900341 Approved no
Call Number ref @ user @ Serial 96620
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Author Kolman, P.; Chmelík, R.; Lovicar, L.\vek; Suchomel, F.
Title Low-coherence interference microscope in transmission mode Type Journal Article
Year 1999 Publication Sciences-New York Abbreviated Journal
Volume 1639 Issue Pages (down) 1065203
Keywords a beam combiner is,as a beam splitter,confocal microscopy,effects,holographic micro-,interference microscopy,low-coherence interferometer,not used,on the mach-zehnder interferometer,optical sectioning,our system is based,scopy,spatial coherence and correlation,the interferometer arms intersect,with a diffraction grating
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Call Number refbase @ admin @ Kolman1999 Serial 5417
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Author Chmelík, R.; Lovicar, L.\vek; Kolman, P.; Spousta, J.; Foret, Z.\vek
Title Polychromatic Coherent Transfer Function Type Journal Article
Year 1999 Publication Sciences-New York Abbreviated Journal
Volume 1639 Issue Pages (down) 1065203
Keywords 1,a low-frequency diffraction grating,beam splitter and the,coherence interferometry,holographic microscope,interference microscope,is used as a,low-,microscope is based on,object and reference,of the low-coherence interference,optical sectioning,our system,the linnik configura-,tion
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Call Number refbase @ admin @ Chmelik1999 Serial 5478
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Author Fan, Y.; Wang, S.; Hernandez, J.; Yenigun, V.B.; Hertlein, G.; Fogarty, C.E.; Lindblad, J.L.; Bergmann, A.
Title Genetic models of apoptosis-induced proliferation decipher activation of JNK and identify a requirement of EGFR signaling for tissue regenerative responses in Drosophila Type Journal Article
Year 2014 Publication PLoS Genetics Abbreviated Journal PLoS Genet
Volume 10 Issue 1 Pages (down) e1004131
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Abstract Recent work in several model organisms has revealed that apoptotic cells are able to stimulate neighboring surviving cells to undergo additional proliferation, a phenomenon termed apoptosis-induced proliferation. This process depends critically on apoptotic caspases such as Dronc, the Caspase-9 ortholog in Drosophila, and may have important implications for tumorigenesis. While it is known that Dronc can induce the activity of Jun N-terminal kinase (JNK) for apoptosis-induced proliferation, the mechanistic details of this activation are largely unknown. It is also controversial if JNK activity occurs in dying or in surviving cells. Signaling molecules of the Wnt and BMP families have been implicated in apoptosis-induced proliferation, but it is unclear if they are the only ones. To address these questions, we have developed an efficient assay for screening and identification of genes that regulate or mediate apoptosis-induced proliferation. We have identified a subset of genes acting upstream of JNK activity including Rho1. We also demonstrate that JNK activation occurs both in apoptotic cells as well as in neighboring surviving cells. In a genetic screen, we identified signaling by the EGFR pathway as important for apoptosis-induced proliferation acting downstream of JNK signaling. These data underscore the importance of genetic screening and promise an improved understanding of the mechanisms of apoptosis-induced proliferation.
Address University of Massachusetts Medical School, Department of Cancer Biology, Worcester, Massachusetts, United States of America ; Graduate Program in Developmental Biology, Baylor College of Medicine, Houston, Texas, United States of America ; MD Anderson Cancer Center, Department of Biochemistry & Molecular Biology, Houston, Texas, United States of America
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ISSN 1553-7390 ISBN Medium
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Notes PMID:24497843 Approved no
Call Number refbase @ admin @ Serial 35454
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