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Author Chi, Y.; Wang, Y.-hua; Yang, L. url  openurl
  Title [The investigation of retinal nerve fiber loss in Alzheimer's disease] Type Journal Article
  Year 2010 Publication (down) [Zhonghua yan ke za zhi] Chinese Journal of Ophthalmology Abbreviated Journal Zhonghua Yan Ke Za Zhi  
  Volume 46 Issue 2 Pages 134-139  
  Keywords Aged; Aged, 80 and over; Alzheimer Disease/*pathology; Case-Control Studies; Female; Humans; Male; Middle Aged; Nerve Fibers/*pathology; Retinal Ganglion Cells/*pathology  
  Abstract OBJECTIVE: To determine if there are retinal abnormalities in Alzheimer's disease and if retinal changes are one of the causes of the visual symptom, and if the changes of retina thickness correlated with the severity of dementia. METHODS: Case-control study. Twelve patients of Alzheimer's disease and seventeen normal controls were included. General eye examinations, mini-mental state examination (MMSE) score and OCT were performed on each patient. Independent-samples t test was used to compare the results obtained from these two groups. RESULTS: The retinal nerve fiber layer (RNFL thickness) overall:Alzheimer's (93.18 +/- 11.36) microm, control (99.44 +/- 8.88) microm, macula thickness min: Alzheimer's (204.00 +/- 52.06) microm, control (211.36 +/- 49.09) microm; inner 1 mm: Alzheimer's (232.50 +/- 23.37) microm, control (242.79 +/- 40.36) microm; between 1-3 mm: Alzheimer's (289.42 +/- 21.37) microm, control (298.43 +/- 23.30) microm; between 3 – 6 mm: Alzheimer's (256.67 +/- 20.04) microm, control (262.86 +/- 20.19) microm was thinner in the patients with Alzheimer's disease. Macula volume inner 1 mm: Alzheimer's (0.183 +/- 0.018) m(3), control (0.188 +/- 0.031) m(3): between 1 – 3 mm: Alzheimer's (1.819 +/- 0.134) m(3), control (1.875 +/- 0.147) m(3); between 3 – 6 mm Alzheimer's (5.443 +/- 0.424) m(3), control (5.571 +/- 0.428) m(3) in the Alzheimer's diseases patients was smaller than that of the controls. There was significant difference (t = -2.519, P < 0.05) in RNFL thickness of the superior quadrant between the two groups Alzheimer's disease (115.09 +/- 14.05) microm, control (129.23 +/- 10.69) microm. CONCLUSIONS: There is retinal nerve fiber loss in patients with Alzheimer's disease, which may be responsible for the visual symptoms. The retinal nerve fiber loss is obviously in the superior quadrant, and it is correlated positively to the severity of dementia.  
  Address Department of Ophthalmology, Peking University First Hospital, Beijing 100034, China  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Chinese Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0412-4081 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:20388347 Approved no  
  Call Number ref @ user @ Serial 67266  
Permanent link to this record
 

 
Author Lu, Y.; Tang, N.; Wang, R. url  openurl
  Title [Retinal ganglion cell loss on APP/PS1 transgenic mice with Alzheimer's disease] Type Journal Article
  Year 2012 Publication (down) [Zhonghua yan ke za zhi] Chinese Journal of Ophthalmology Abbreviated Journal Zhonghua Yan Ke Za Zhi  
  Volume 48 Issue 9 Pages 836-841  
  Keywords *Alzheimer Disease; Animals; Cell Count; *Disease Models, Animal; Female; Humans; Mice; Mice, Inbred C57BL; Mice, Transgenic; Retinal Ganglion Cells/*cytology  
  Abstract OBJECTIVE: To investigate the retinal nerve cell changes in number by tests on APP/PS1 double transgenic mice. METHODS: Experimental study. Comparison was made between 10 female 11-month-old APP/PS1 double transgenic mice with Alzheimer's disease (model group) and 10 non-transgenic female mice of the same background and age (control group). Retinal ganglion cell (RGC) was retrograde labeled by injecting horse radish peroxidase (HRP) into the bilateral optic nerve layer of the superior colliculus of two groups. After 48 hours, all mice were perfused sacrificed. The brains were frozen, mode slices, stained with methyl-alcohol-Congo. The retina peeled from right eye was conducted HRP histochemistry reaction to count RGC by computerized image analyzer. The left eyes were treated with paraffin-embedded, mode slices, stained with hematoxylin and eosin (HE) to count the neuron numbers of each retina layers. The neuron numbers of each retina layer for control group and model group were statistically analyzed using t test for independent samples. RESULTS: The brains showed positive in the model group and the brains showed negative in the control group after stained with methyl-alcohol-Congo. By counting retinal ganglion cells traced with HRP, the number of RGC was statistical different between two groups at 112.78 +/- 7.70 within per field for the control group against 78.72 +/- 11.35 within per field for the model group. The RGC of the model group was comparatively much less than the control group (t = 27.28, P < 0.01). By counting cells of retina stained with HE, the number of inner and outer nuclear layer cells were not statistical different between two groups of each layer (P > 0.05), the number of RGC in the control group and the model group were respectively 8.17 +/- 1.17 within per field, 5.17 +/- 0.75 within per field. The cells in retinal ganglion layer in the model group were significantly reduced (t = 52.88, P < 0.01). CONCLUSION: The results imply that the number of RGC reduced in 11-month-old APP/PS1 double transgenic mice with Alzheimer's disease.  
  Address Department of Ophthalmology, Capital Medical University, Beijing, China. louiseluyan@yahoo.com.cn  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Chinese Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0412-4081 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:23141581 Approved no  
  Call Number ref @ user @ Serial 67716  
Permanent link to this record
 

 
Author Chi, Y.; Wang, Y.-hua; Yang, L. url  openurl
  Title [The investigation of retinal nerve fiber loss in Alzheimer's disease] Type Journal Article
  Year 2010 Publication (down) [Zhonghua yan ke za zhi] Chinese Journal of Ophthalmology Abbreviated Journal Zhonghua Yan Ke Za Zhi  
  Volume 46 Issue 2 Pages 134-139  
  Keywords Aged; Aged, 80 and over; Alzheimer Disease/*pathology; Case-Control Studies; Female; Humans; Male; Middle Aged; Nerve Fibers/*pathology; Retinal Ganglion Cells/*pathology  
  Abstract OBJECTIVE: To determine if there are retinal abnormalities in Alzheimer's disease and if retinal changes are one of the causes of the visual symptom, and if the changes of retina thickness correlated with the severity of dementia. METHODS: Case-control study. Twelve patients of Alzheimer's disease and seventeen normal controls were included. General eye examinations, mini-mental state examination (MMSE) score and OCT were performed on each patient. Independent-samples t test was used to compare the results obtained from these two groups. RESULTS: The retinal nerve fiber layer (RNFL thickness) overall:Alzheimer's (93.18 +/- 11.36) microm, control (99.44 +/- 8.88) microm, macula thickness min: Alzheimer's (204.00 +/- 52.06) microm, control (211.36 +/- 49.09) microm; inner 1 mm: Alzheimer's (232.50 +/- 23.37) microm, control (242.79 +/- 40.36) microm; between 1-3 mm: Alzheimer's (289.42 +/- 21.37) microm, control (298.43 +/- 23.30) microm; between 3 – 6 mm: Alzheimer's (256.67 +/- 20.04) microm, control (262.86 +/- 20.19) microm was thinner in the patients with Alzheimer's disease. Macula volume inner 1 mm: Alzheimer's (0.183 +/- 0.018) m(3), control (0.188 +/- 0.031) m(3): between 1 – 3 mm: Alzheimer's (1.819 +/- 0.134) m(3), control (1.875 +/- 0.147) m(3); between 3 – 6 mm Alzheimer's (5.443 +/- 0.424) m(3), control (5.571 +/- 0.428) m(3) in the Alzheimer's diseases patients was smaller than that of the controls. There was significant difference (t = -2.519, P < 0.05) in RNFL thickness of the superior quadrant between the two groups Alzheimer's disease (115.09 +/- 14.05) microm, control (129.23 +/- 10.69) microm. CONCLUSIONS: There is retinal nerve fiber loss in patients with Alzheimer's disease, which may be responsible for the visual symptoms. The retinal nerve fiber loss is obviously in the superior quadrant, and it is correlated positively to the severity of dementia.  
  Address Department of Ophthalmology, Peking University First Hospital, Beijing 100034, China  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Chinese Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0412-4081 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:20388347 Approved no  
  Call Number ref @ user @ Serial 67836  
Permanent link to this record
 

 
Author Itoh, Y.; Ohuchi, M.; Yoshida, I.; Shoji, Y.; Ohmi, M. url  openurl
  Title [Surgical treatment in the patients with ocular type myasthenia gravis associated with thymoma] Type Journal Article
  Year 1993 Publication (down) [Zasshi] [Journal]. Nihon Kyobu Geka Gakkai Abbreviated Journal Nihon Kyobu Geka Gakkai Zasshi  
  Volume 41 Issue 7 Pages 1204-1207  
  Keywords Adult; Blepharoptosis/*complications; Female; Humans; Male; Middle Aged; Myasthenia Gravis/complications/*surgery; *Thymectomy; Thymoma/complications/*surgery; Thymus Neoplasms/complications/*surgery  
  Abstract During past 16 years, 192 patients underwent surgery for myasthenia gravis including 40 patients with pure ocular symptoms in our institute. In these 40 patients, 8 were associated with thymoma. The clinical stages of the thymomas were registered into Stage I (n = 5), Stage II (n = 1), Stage III (n = 1), Stage IV (n = 1) according to the classification of Masaoka and colleagues. All patients underwent extended thymothymectomy. The patient in stage III had been well until generalized myasthenic symptoms appeared 4 years after the surgery. Since the chest X-ray film revealed the tumor shadow on the right diaphragm, removal of the tumor was performed. Although he developed myasthenic crisis postoperatively, he is well controlled medically. Other 7 patients have been doing well. We concluded that a close postoperative follow up should be performed for the patients with ocular type myasthenia gravis associated with thymoma.  
  Address Department of Thoracic and Cardiovascular Surgery, Tohoku University School of Medicine, Sendai, Japan  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Japanese Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0369-4739 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:8376890 Approved no  
  Call Number refbase @ user @ Serial 2208  
Permanent link to this record
 

 
Author Itoh, Y.; Ohuchi, M.; Yoshida, I.; Ohmi, M. url  openurl
  Title [Surgical treatment of myasthenia gravis associated with Graves's disease] Type Journal Article
  Year 1992 Publication (down) [Zasshi] [Journal]. Nihon Kyobu Geka Gakkai Abbreviated Journal Nihon Kyobu Geka Gakkai Zasshi  
  Volume 40 Issue 4 Pages 587-591  
  Keywords Adult; Female; Graves Disease/*complications/surgery; Humans; Male; Middle Aged; Myasthenia Gravis/complications/*surgery; Thymectomy; Thyroidectomy  
  Abstract During past 30 years, we experienced 253 patients who underwent surgery for myasthenia gravis. Among these patients, 9 were associated with Graves' disease. No patients had thymoma. Five patients underwent thymectomy after they had become euthyroid by medical treatment, though four patients required subtotal thyroidectomy before thymectomy. One patient developed myasthenic crisis following thyroidectomy and was treated with respirator for 5 days. But thymectomy was performed without myasthenic crisis in these four patients between 25 days and 60 days after thyroidectomy. They have been doing well and no see-saw phenomenon was presented. Thymectomy is safe and effective even in the patients with Graves's disease, and we recommend to perform it after they become euthyroid by medical or surgical treatment.  
  Address Division of Thoracic and Cardiovascular Surgery, Sendai National Hospital, Japan  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Japanese Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0369-4739 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:1613289 Approved no  
  Call Number refbase @ user @ Serial 2216  
Permanent link to this record
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