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Author Willmann, M.; Klimek, A.M.; Vogel, W.; Liese, J.; Marschal, M.; Autenrieth, I.B.; Peter, S.; Buhl, M. url  doi
openurl 
  Title Clinical and treatment-related risk factors for nosocomial colonisation with extensively drug-resistant Pseudomonas aeruginosa in a haematological patient population: a matched case control study Type Journal Article
  Year 2014 Publication BMC Infectious Diseases Abbreviated Journal BMC Infect Dis  
  Volume 14 Issue Pages 650  
  Keywords Adult; Aged; Aged, 80 and over; Case-Control Studies; Cross Infection/diagnosis/*etiology/immunology; *Drug Resistance, Multiple, Bacterial; Female; Hematologic Diseases/complications/therapy; Humans; *Immunocompromised Host; Logistic Models; Male; Middle Aged; Pseudomonas Infections/diagnosis/*etiology/immunology; Pseudomonas aeruginosa/*isolation & purification; Risk Factors  
  Abstract BACKGROUND: This study aimed to investigate risk factors for colonisation with extensively drug-resistant P. aeruginosa (XDR-PA) in immunocompromised patients and to build a clinical risk score (CRS) based on these results. METHODS: We conducted a matched case-control study with 31 cases and 93 controls (1:3). Cases were colonised with XDR-PA during hospitalisation. Independent risk factors were determined using a three step conditional logistic regression procedure. A CRS was built with respect to the corresponding risk fraction of each risk factor, and its discriminatory power was estimated by receiver operating characteristic (ROC) analysis. RESULTS: The presence of a central venous catheter (OR 7.41, P = 0.0008), the presence of a urinary catheter (OR 21.04, P < 0.0001), CRP > 10 mg/dl (OR 7.36, P = 0.0015), and ciprofloxacin administration (OR 5.53, P = 0.025) were independent risk factors. The CRS exhibited a high discriminatory power, defining a high risk population with an approximately fourteen times greater risk for XDR-PA colonisation. CONCLUSIONS: Unnecessary use of antibiotics, particularly ciprofloxacin should be avoided, and a high standard of infection control measures must be achieved when using medical devices. A CRS can be used for adaptation of the active screening culture policy to the local setting.  
  Address German Center for Infection Research (DZIF), partner site Tubingen, Tubingen, Germany. michael.buhl@med.uni-tuebingen.de  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1471-2334 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:25490897 Approved no  
  Call Number ref @ user @ Serial (down) 100509  
Permanent link to this record
 

 
Author Williams, P.J.; Lea, A.S.; McCaffrey, E.; Guthrie, J.D.J. url  openurl
  Title Use of the Hickman catheter for the treatment of lower extremity infections Type Journal Article
  Year 1985 Publication The Journal of Foot Surgery Abbreviated Journal J Foot Surg  
  Volume 24 Issue 5 Pages 335-338  
  Keywords Anti-Bacterial Agents/*administration & dosage; *Catheters, Indwelling; Drug Therapy, Combination; Female; Fibula/*injuries; Foot Diseases/*drug therapy; Fractures, Open/*complications; Humans; Infusions, Parenteral; Male; Middle Aged; Osteomyelitis/*drug therapy; Proteus Infections/drug therapy; Proteus mirabilis/drug effects; Pseudomonas Infections/drug therapy; Skin Ulcer/*drug therapy; Staphylococcal Infections/drug therapy; Tibial Fractures/*complications; Ticarcillin/administration & dosage; Tobramycin/administration & dosage  
  Abstract The authors discuss the use of a cuffed, Silastic catheter, which can be of great value in the reduction of morbidity when dealing with lower extremity infections. When a patient's condition demands the use of long-term antibiotic and/or aminoglyoside therapy, this indwelling central venous catheter can allow easy access to the vascular system and markedly decrease the amount of time the patient has to stay in the hospital. This form of therapy involves the patient in the treatment and displays no mortality and minimal morbidity associated with catheter placement and care.  
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  Corporate Author Thesis  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0449-2544 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:3905931 Approved no  
  Call Number ref @ user @ Serial (down) 100508  
Permanent link to this record
 

 
Author Williams, D. url  openurl
  Title Catheters, materials and infection Type Journal Article
  Year 2002 Publication Medical Device Technology Abbreviated Journal Med Device Technol  
  Volume 13 Issue 2 Pages 8-11  
  Keywords Anti-Bacterial Agents; Anti-Infective Agents; Candida/growth & development/isolation & purification; Catheterization, Central Venous/*adverse effects/instrumentation; Catheters, Indwelling/*microbiology; Colony Count, Microbial; Equipment Contamination; Humans; Incidence; Staphylococcus aureus/growth & development/isolation & purification; Staphylococcus epidermidis/growth & development/isolation & purification; Surgical Wound Infection/*epidemiology/etiology; United Kingdom/epidemiology  
  Abstract The possible influence of catheter material on infection rates, particularly in relation to the use of central venous catheters, has been a controversial matter for many years. Some of the factors that control the occurrence of infection are considered in this article.  
  Address Department of Clinical Engineering, University of Liverpool. dfw.ce@liverpool.ac.uk  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1048-6690 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:11984995 Approved no  
  Call Number ref @ user @ Serial (down) 100507  
Permanent link to this record
 

 
Author Wilkins, S.; Millar, M.; Hemsworth, S.; Johnson, G.; Warwick, S.; Pizer, B. url  doi
openurl 
  Title Vibrio harveyi sepsis in a child with cancer Type Journal Article
  Year 2008 Publication Pediatric Blood & Cancer Abbreviated Journal Pediatr Blood Cancer  
  Volume 50 Issue 4 Pages 891-892  
  Keywords Anti-Bacterial Agents/therapeutic use; Antineoplastic Combined Chemotherapy Protocols/therapeutic use; Catheterization, Central Venous/*adverse effects; Child; Humans; Lymphoma, Large-Cell, Anaplastic/*therapy; Male; Seawater/*adverse effects/microbiology; Sepsis/drug therapy/*microbiology; Stem Cell Transplantation; Swimming; Vibrio Infections/drug therapy/*physiopathology  
  Abstract A paediatric oncology patient presented with central line sepsis caused by Vibrio harveyi, a gram negative bioluminescent marine bacterium known to be pathogenic to fish and marine invertebrates, after swimming in the sea.  
  Address Department of Paediatric Oncology, Royal Liverpool Children's NHS Trust, Liverpool, UK. drsimyuk@yahoo.co.uk  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1545-5009 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:17957758 Approved no  
  Call Number ref @ user @ Serial (down) 100506  
Permanent link to this record
 

 
Author Wiederhold, N.P.; Coyle, E.A.; Raad, I.I.; Prince, R.A.; Lewis, R.E. url  doi
openurl 
  Title Antibacterial activity of linezolid and vancomycin in an in vitro pharmacodynamic model of gram-positive catheter-related bacteraemia Type Journal Article
  Year 2005 Publication The Journal of Antimicrobial Chemotherapy Abbreviated Journal J Antimicrob Chemother  
  Volume 55 Issue 5 Pages 792-795  
  Keywords Acetamides/*pharmacology; Anti-Bacterial Agents/*pharmacology; Bacteremia/microbiology; Biofilms/*drug effects/growth & development; Catheterization, Central Venous/*adverse effects; Colony Count, Microbial; Enterococcus faecium/drug effects; Gram-Positive Bacterial Infections/microbiology; Gram-Positive Cocci/*drug effects; Humans; Linezolid; Microbial Sensitivity Tests; *Models, Biological; Oxazolidinones/*pharmacology; Staphylococcus aureus/drug effects; Staphylococcus epidermidis/drug effects; Vancomycin/pharmacokinetics/*pharmacology  
  Abstract OBJECTIVES: The aim of this study was to compare the activity of linezolid and vancomycin in an in vitro pharmacodynamic model to assess potential differences in activity against biofilm-embedded organisms. METHODS: Single-lumen central venous catheters colonized with biofilm-embedded Staphylococcus aureus, Staphylococcus epidermidis or vancomycin-resistant Enterococcus faecium (VRE) were treated with simulated clinical dosing regimens of linezolid 600 mg every 12 h or vancomycin 1 g every 12 h in a one-compartment in vitro pharmacodynamic model. Quantitative cultures were sampled through the catheter and peripheral ports over 48 h to dynamically assess changes in the burden of catheter colonization and organism seeding, respectively. At 24 and 48 h catheters were removed, sonicated and cultured for adherent organisms. RESULTS: Both linezolid and vancomycin suppressed bacterial growth on the catheter and release of S. aureus and S. epidermidis into the model compared with controls (P < 0.05), while linezolid also suppressed counts compared with control and vancomycin versus VRE. Neither agent completely eradicated bacterial colonization of the catheters. MICs for the isolates recovered from the model did not increase over time with linezolid or vancomycin exposure. CONCLUSIONS: Lack of activity against biofilm-embedded organisms appeared to be the primary reason for microbiological failure of both drugs in the model.  
  Address The University of Houston College of Pharmacy, Houston, TX 77030, USA  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0305-7453 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:15814598 Approved no  
  Call Number ref @ user @ Serial (down) 100505  
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