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Author Harris, R.A.; Shah, R.; Hollister, E.B.; Tronstad, R.R.; Hovdenak, N.; Szigeti, R.; Versalovic, J.; Kellermayer, R.
Title Colonic Mucosal Epigenome and Microbiome Development in Children and Adolescents Type Journal Article
Year 2016 Publication Journal of Immunology Research Abbreviated Journal J Immunol Res
Volume (down) 2016 Issue Pages 9170162
Keywords Adolescent; Child; Child, Preschool; Colitis, Ulcerative/genetics/immunology/microbiology/pathology; CpG Islands/immunology; Crohn Disease/genetics/immunology/microbiology/pathology; *DNA Methylation; Epigenesis, Genetic/*immunology; Female; Healthy Volunteers; Humans; Intestinal Mucosa/cytology/*immunology/microbiology; Male; Microbiota/genetics/*immunology; Proteins/genetics/immunology; RNA, Ribosomal, 16S/genetics; Sodium-Hydrogen Antiporter/genetics/immunology
Abstract Epigenetic and microbiome changes during pediatric development have been implicated as important elements in the developmental origins of inflammatory bowel diseases (IBDs) including Crohn's disease (CD) and ulcerative colitis (UC), which are linked to early onset colorectal cancer (CRC). Colonic mucosal samples from 22 control children between 3.5 and 17.5 years of age were studied by Infinium HumanMethylation450 BeadChips and, in 10 cases, by 454 pyrosequencing of the bacterial 16S rRNA gene. Intercalating age-specific DNA methylation and microbiome changes were identified, which may have significant translational relevance in the developmental origins of IBD and CRC.
Address Texas Children's Hospital, Houston, TX 77030, USA; Section of Pediatric Gastroenterology, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA; USDA/ARS Children's Nutrition Research Center, Houston, TX 77030, USA
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 2314-7156 ISBN Medium
Area Expedition Conference
Notes PMID:27006956 Approved no
Call Number ref @ user @ Serial 96384
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Author Adeberg, S.; Harrabi, S.B.; Bougatf, N.; Bernhardt, D.; Mohr, A.; Rieber, J.; Koelsche, C.; Rieken, S.; Debus, J.
Title Do Increased Doses to Stem-Cell Niches during Radiation Therapy Improve Glioblastoma Survival? Type Journal Article
Year 2016 Publication Stem Cells International Abbreviated Journal Stem Cells Int
Volume (down) 2016 Issue Pages 8793462
Keywords
Abstract Background and Purpose. The reasons for the inevitable glioblastoma recurrence are yet understood. However, recent data suggest that tumor cancer stem cells (CSCs) in the stem-cell niches, with self-renewing capacities, might be responsible for tumor initiation, propagation, and recurrence. We aimed to analyze the effect of higher radiation doses to the stem-cell niches on progression-free survival (PFS) and overall survival (OS) in glioblastoma patients. Materials and Methods. Sixty-five patients with primary glioblastoma treated with radiation therapy were included in this retrospective analysis. The SVZ and DG were segmented on treatment planning magnetic resonance imaging, and the dose distributions to the structures were calculated. The relationship of dosimetry data and survival was evaluated using the Cox regression analysis. Results. Conventionally fractionated patients (n = 54) who received higher doses (D mean >/= 40 Gy) to the IL SVZ showed improved PFS (8.5 versus 5.2 months; p = 0.013). Furthermore, higher doses (D mean >/= 30 Gy) to the CL SVZ were associated with increased PFS (10.1 versus 6.9 months; p = 0.025). Conclusion. Moderate higher IL SVZ doses (>/=40 Gy) and CL SVZ doses (>/=30 Gy) are associated with improved PFS. Higher doses to the DG, the second stem-cell niche, did not influence the survival. Targeting the potential cancer stem cells in the SVZ might be a promising treatment approach for glioblastoma and should be addressed in a prospective randomized trial.
Address Department of Radiation Oncology, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany; Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany; Heidelberg Ion-Beam Therapy Center (HIT), Im Neuenheimer Feld 450, 69120 Heidelberg, Germany; Heidelberg Institute of Radiation Oncology (HIRO), University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1687-966X ISBN Medium
Area Expedition Conference
Notes PMID:27429623 Approved no
Call Number ref @ user @ Serial 96645
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Author Gomez, F.; Corchuelo, J.; Curcio, C.-L.; Calzada, M.-T.; Mendez, F.
Title SABE Colombia: Survey on Health, Well-Being, and Aging in Colombia-Study Design and Protocol Type Journal Article
Year 2016 Publication Current Gerontology and Geriatrics Research Abbreviated Journal Curr Gerontol Geriatr Res
Volume (down) 2016 Issue Pages 7910205
Keywords
Abstract Objective. To describe the design of the SABE Colombia study. The major health study of the old people in Latin America and the Caribbean (LAC) is the Survey on Health, Well-Being, and Aging in LAC, SABE (from initials in Spanish: SAlud, Bienestar & Envejecimiento). Methods. The SABE Colombia is a population-based cross-sectional study on health, aging, and well-being of elderly individuals aged at least 60 years focusing attention on social determinants of health inequities. Methods and design were similar to original LAC SABE. The total sample size of the study at the urban and rural research sites (244 municipalities) was 23.694 elderly Colombians representative of the total population. The study had three components: (1) a questionnaire covering active aging determinants including anthropometry, blood pressure measurement, physical function, and biochemical and hematological measures; (2) a subsample survey among family caregivers; (3) a qualitative study with gender and cultural perspectives of quality of life to understand different dimensions of people meanings. Conclusions. The SABE Colombia is a comprehensive, multidisciplinary study of the elderly with respect to active aging determinants. The results of this study are intended to inform public policies aimed at tackling health inequalities for the aging society in Colombia.
Address Escuela de Salud Publica, Universidad del Valle, Research Group of Epidemiology and Population Health (GEPH), Cali, Colombia
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1687-7063 ISBN Medium
Area Expedition Conference
Notes PMID:27956896 Approved no
Call Number ref @ user @ Serial 97046
Permanent link to this record
 

 
Author Gomez, F.; Corchuelo, J.; Curcio, C.-L.; Calzada, M.-T.; Mendez, F.
Title SABE Colombia: Survey on Health, Well-Being, and Aging in Colombia-Study Design and Protocol Type Journal Article
Year 2016 Publication Current Gerontology and Geriatrics Research Abbreviated Journal Curr Gerontol Geriatr Res
Volume (down) 2016 Issue Pages 7910205
Keywords
Abstract Objective. To describe the design of the SABE Colombia study. The major health study of the old people in Latin America and the Caribbean (LAC) is the Survey on Health, Well-Being, and Aging in LAC, SABE (from initials in Spanish: SAlud, Bienestar & Envejecimiento). Methods. The SABE Colombia is a population-based cross-sectional study on health, aging, and well-being of elderly individuals aged at least 60 years focusing attention on social determinants of health inequities. Methods and design were similar to original LAC SABE. The total sample size of the study at the urban and rural research sites (244 municipalities) was 23.694 elderly Colombians representative of the total population. The study had three components: (1) a questionnaire covering active aging determinants including anthropometry, blood pressure measurement, physical function, and biochemical and hematological measures; (2) a subsample survey among family caregivers; (3) a qualitative study with gender and cultural perspectives of quality of life to understand different dimensions of people meanings. Conclusions. The SABE Colombia is a comprehensive, multidisciplinary study of the elderly with respect to active aging determinants. The results of this study are intended to inform public policies aimed at tackling health inequalities for the aging society in Colombia.
Address Escuela de Salud Publica, Universidad del Valle, Research Group of Epidemiology and Population Health (GEPH), Cali, Colombia
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1687-7063 ISBN Medium
Area Expedition Conference
Notes PMID:27956896 Approved no
Call Number ref @ user @ Serial 97086
Permanent link to this record
 

 
Author Gomez, F.; Corchuelo, J.; Curcio, C.-L.; Calzada, M.-T.; Mendez, F.
Title SABE Colombia: Survey on Health, Well-Being, and Aging in Colombia-Study Design and Protocol Type Journal Article
Year 2016 Publication Current Gerontology and Geriatrics Research Abbreviated Journal Curr Gerontol Geriatr Res
Volume (down) 2016 Issue Pages 7910205
Keywords
Abstract Objective. To describe the design of the SABE Colombia study. The major health study of the old people in Latin America and the Caribbean (LAC) is the Survey on Health, Well-Being, and Aging in LAC, SABE (from initials in Spanish: SAlud, Bienestar & Envejecimiento). Methods. The SABE Colombia is a population-based cross-sectional study on health, aging, and well-being of elderly individuals aged at least 60 years focusing attention on social determinants of health inequities. Methods and design were similar to original LAC SABE. The total sample size of the study at the urban and rural research sites (244 municipalities) was 23.694 elderly Colombians representative of the total population. The study had three components: (1) a questionnaire covering active aging determinants including anthropometry, blood pressure measurement, physical function, and biochemical and hematological measures; (2) a subsample survey among family caregivers; (3) a qualitative study with gender and cultural perspectives of quality of life to understand different dimensions of people meanings. Conclusions. The SABE Colombia is a comprehensive, multidisciplinary study of the elderly with respect to active aging determinants. The results of this study are intended to inform public policies aimed at tackling health inequalities for the aging society in Colombia.
Address Escuela de Salud Publica, Universidad del Valle, Research Group of Epidemiology and Population Health (GEPH), Cali, Colombia
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1687-7063 ISBN Medium
Area Expedition Conference
Notes PMID:27956896 Approved no
Call Number ref @ user @ Serial 97126
Permanent link to this record