| Records |
| Author |
Harris, R.A.; Shah, R.; Hollister, E.B.; Tronstad, R.R.; Hovdenak, N.; Szigeti, R.; Versalovic, J.; Kellermayer, R. |
| Title |
Colonic Mucosal Epigenome and Microbiome Development in Children and Adolescents |
Type |
Journal Article |
| Year |
2016 |
Publication |
Journal of Immunology Research |
Abbreviated Journal |
J Immunol Res |
Volume  |
2016 |
Issue |
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Pages |
9170162 |
| Keywords |
Adolescent; Child; Child, Preschool; Colitis, Ulcerative/genetics/immunology/microbiology/pathology; CpG Islands/immunology; Crohn Disease/genetics/immunology/microbiology/pathology; *DNA Methylation; Epigenesis, Genetic/*immunology; Female; Healthy Volunteers; Humans; Intestinal Mucosa/cytology/*immunology/microbiology; Male; Microbiota/genetics/*immunology; Proteins/genetics/immunology; RNA, Ribosomal, 16S/genetics; Sodium-Hydrogen Antiporter/genetics/immunology |
| Abstract |
Epigenetic and microbiome changes during pediatric development have been implicated as important elements in the developmental origins of inflammatory bowel diseases (IBDs) including Crohn's disease (CD) and ulcerative colitis (UC), which are linked to early onset colorectal cancer (CRC). Colonic mucosal samples from 22 control children between 3.5 and 17.5 years of age were studied by Infinium HumanMethylation450 BeadChips and, in 10 cases, by 454 pyrosequencing of the bacterial 16S rRNA gene. Intercalating age-specific DNA methylation and microbiome changes were identified, which may have significant translational relevance in the developmental origins of IBD and CRC. |
| Address |
Texas Children's Hospital, Houston, TX 77030, USA; Section of Pediatric Gastroenterology, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA; USDA/ARS Children's Nutrition Research Center, Houston, TX 77030, USA |
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English |
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| ISSN |
2314-7156 |
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| Notes |
PMID:27006956 |
Approved |
no |
| Call Number |
ref @ user @ |
Serial |
96384 |
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| Author |
Adeberg, S.; Harrabi, S.B.; Bougatf, N.; Bernhardt, D.; Mohr, A.; Rieber, J.; Koelsche, C.; Rieken, S.; Debus, J. |
| Title |
Do Increased Doses to Stem-Cell Niches during Radiation Therapy Improve Glioblastoma Survival? |
Type |
Journal Article |
| Year |
2016 |
Publication |
Stem Cells International |
Abbreviated Journal |
Stem Cells Int |
| Volume |
2016 |
Issue |
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Pages |
8793462 |
| Keywords |
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| Abstract |
Background and Purpose. The reasons for the inevitable glioblastoma recurrence are yet understood. However, recent data suggest that tumor cancer stem cells (CSCs) in the stem-cell niches, with self-renewing capacities, might be responsible for tumor initiation, propagation, and recurrence. We aimed to analyze the effect of higher radiation doses to the stem-cell niches on progression-free survival (PFS) and overall survival (OS) in glioblastoma patients. Materials and Methods. Sixty-five patients with primary glioblastoma treated with radiation therapy were included in this retrospective analysis. The SVZ and DG were segmented on treatment planning magnetic resonance imaging, and the dose distributions to the structures were calculated. The relationship of dosimetry data and survival was evaluated using the Cox regression analysis. Results. Conventionally fractionated patients (n = 54) who received higher doses (D mean >/= 40 Gy) to the IL SVZ showed improved PFS (8.5 versus 5.2 months; p = 0.013). Furthermore, higher doses (D mean >/= 30 Gy) to the CL SVZ were associated with increased PFS (10.1 versus 6.9 months; p = 0.025). Conclusion. Moderate higher IL SVZ doses (>/=40 Gy) and CL SVZ doses (>/=30 Gy) are associated with improved PFS. Higher doses to the DG, the second stem-cell niche, did not influence the survival. Targeting the potential cancer stem cells in the SVZ might be a promising treatment approach for glioblastoma and should be addressed in a prospective randomized trial. |
| Address |
Department of Radiation Oncology, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany; Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany; Heidelberg Ion-Beam Therapy Center (HIT), Im Neuenheimer Feld 450, 69120 Heidelberg, Germany; Heidelberg Institute of Radiation Oncology (HIRO), University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany |
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English |
Summary Language |
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| ISSN |
1687-966X |
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| Notes |
PMID:27429623 |
Approved |
no |
| Call Number |
ref @ user @ |
Serial |
96645 |
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| Author |
Gomez, F.; Corchuelo, J.; Curcio, C.-L.; Calzada, M.-T.; Mendez, F. |
| Title |
SABE Colombia: Survey on Health, Well-Being, and Aging in Colombia-Study Design and Protocol |
Type |
Journal Article |
| Year |
2016 |
Publication |
Current Gerontology and Geriatrics Research |
Abbreviated Journal |
Curr Gerontol Geriatr Res |
| Volume |
2016 |
Issue |
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Pages |
7910205 |
| Keywords |
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| Abstract |
Objective. To describe the design of the SABE Colombia study. The major health study of the old people in Latin America and the Caribbean (LAC) is the Survey on Health, Well-Being, and Aging in LAC, SABE (from initials in Spanish: SAlud, Bienestar & Envejecimiento). Methods. The SABE Colombia is a population-based cross-sectional study on health, aging, and well-being of elderly individuals aged at least 60 years focusing attention on social determinants of health inequities. Methods and design were similar to original LAC SABE. The total sample size of the study at the urban and rural research sites (244 municipalities) was 23.694 elderly Colombians representative of the total population. The study had three components: (1) a questionnaire covering active aging determinants including anthropometry, blood pressure measurement, physical function, and biochemical and hematological measures; (2) a subsample survey among family caregivers; (3) a qualitative study with gender and cultural perspectives of quality of life to understand different dimensions of people meanings. Conclusions. The SABE Colombia is a comprehensive, multidisciplinary study of the elderly with respect to active aging determinants. The results of this study are intended to inform public policies aimed at tackling health inequalities for the aging society in Colombia. |
| Address |
Escuela de Salud Publica, Universidad del Valle, Research Group of Epidemiology and Population Health (GEPH), Cali, Colombia |
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English |
Summary Language |
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Original Title |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
1687-7063 |
ISBN |
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Expedition |
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Conference |
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| Notes |
PMID:27956896 |
Approved |
no |
| Call Number |
ref @ user @ |
Serial |
97046 |
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| Author |
Gomez, F.; Corchuelo, J.; Curcio, C.-L.; Calzada, M.-T.; Mendez, F. |
| Title |
SABE Colombia: Survey on Health, Well-Being, and Aging in Colombia-Study Design and Protocol |
Type |
Journal Article |
| Year |
2016 |
Publication |
Current Gerontology and Geriatrics Research |
Abbreviated Journal |
Curr Gerontol Geriatr Res |
| Volume |
2016 |
Issue |
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Pages |
7910205 |
| Keywords |
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| Abstract |
Objective. To describe the design of the SABE Colombia study. The major health study of the old people in Latin America and the Caribbean (LAC) is the Survey on Health, Well-Being, and Aging in LAC, SABE (from initials in Spanish: SAlud, Bienestar & Envejecimiento). Methods. The SABE Colombia is a population-based cross-sectional study on health, aging, and well-being of elderly individuals aged at least 60 years focusing attention on social determinants of health inequities. Methods and design were similar to original LAC SABE. The total sample size of the study at the urban and rural research sites (244 municipalities) was 23.694 elderly Colombians representative of the total population. The study had three components: (1) a questionnaire covering active aging determinants including anthropometry, blood pressure measurement, physical function, and biochemical and hematological measures; (2) a subsample survey among family caregivers; (3) a qualitative study with gender and cultural perspectives of quality of life to understand different dimensions of people meanings. Conclusions. The SABE Colombia is a comprehensive, multidisciplinary study of the elderly with respect to active aging determinants. The results of this study are intended to inform public policies aimed at tackling health inequalities for the aging society in Colombia. |
| Address |
Escuela de Salud Publica, Universidad del Valle, Research Group of Epidemiology and Population Health (GEPH), Cali, Colombia |
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Place of Publication |
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English |
Summary Language |
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Original Title |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
1687-7063 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
PMID:27956896 |
Approved |
no |
| Call Number |
ref @ user @ |
Serial |
97086 |
| Permanent link to this record |
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| Author |
Gomez, F.; Corchuelo, J.; Curcio, C.-L.; Calzada, M.-T.; Mendez, F. |
| Title |
SABE Colombia: Survey on Health, Well-Being, and Aging in Colombia-Study Design and Protocol |
Type |
Journal Article |
| Year |
2016 |
Publication |
Current Gerontology and Geriatrics Research |
Abbreviated Journal |
Curr Gerontol Geriatr Res |
| Volume |
2016 |
Issue |
|
Pages |
7910205 |
| Keywords |
|
| Abstract |
Objective. To describe the design of the SABE Colombia study. The major health study of the old people in Latin America and the Caribbean (LAC) is the Survey on Health, Well-Being, and Aging in LAC, SABE (from initials in Spanish: SAlud, Bienestar & Envejecimiento). Methods. The SABE Colombia is a population-based cross-sectional study on health, aging, and well-being of elderly individuals aged at least 60 years focusing attention on social determinants of health inequities. Methods and design were similar to original LAC SABE. The total sample size of the study at the urban and rural research sites (244 municipalities) was 23.694 elderly Colombians representative of the total population. The study had three components: (1) a questionnaire covering active aging determinants including anthropometry, blood pressure measurement, physical function, and biochemical and hematological measures; (2) a subsample survey among family caregivers; (3) a qualitative study with gender and cultural perspectives of quality of life to understand different dimensions of people meanings. Conclusions. The SABE Colombia is a comprehensive, multidisciplinary study of the elderly with respect to active aging determinants. The results of this study are intended to inform public policies aimed at tackling health inequalities for the aging society in Colombia. |
| Address |
Escuela de Salud Publica, Universidad del Valle, Research Group of Epidemiology and Population Health (GEPH), Cali, Colombia |
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Thesis |
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Place of Publication |
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English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
1687-7063 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
PMID:27956896 |
Approved |
no |
| Call Number |
ref @ user @ |
Serial |
97126 |
| Permanent link to this record |
