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Author (up) Caine, C.; Deshmukh, S.; Gondi, V.; Mehta, M.; Tome, W.; Corn, B.W.; Kanner, A.; Rowley, H.; Kundapur, V.; DeNittis, A.; Greenspoon, J.N.; Konski, A.A.; Bauman, G.S.; Raben, A.; Shi, W.; Wendland, M.; Kachnic, L. url  doi
openurl 
  Title CogState computerized memory tests in patients with brain metastases: secondary endpoint results of NRG Oncology RTOG 0933 Type Journal Article
  Year 2016 Publication Journal of Neuro-Oncology Abbreviated Journal J Neurooncol  
  Volume 126 Issue 2 Pages 327-336  
  Keywords Hvlt-R; Islt; NRG Oncology RTOG 0933; Neurocognitive; Oclt  
  Abstract Whole brain radiotherapy (WBRT) is associated with memory dysfunction. As part of NRG Oncology RTOG 0933, a phase II study of WBRT for brain metastases that conformally avoided the hippocampal stem cell compartment (HA-WBRT), memory was assessed pre- and post-HA-WBRT using both traditional and computerized memory tests. We examined whether the computerized tests yielded similar findings and might serve as possible alternatives for assessment of memory in multi-institution clinical trials. Adult patients with brain metastases received HA-WBRT to 30 Gy in ten fractions and completed Hopkins Verbal Learning Test-Revised (HVLT-R), CogState International Shopping List Test (ISLT) and One Card Learning Test (OCLT), at baseline, 2 and 4 months. Tests' completion rates were 52-53 % at 2 months and 34-42 % at 4 months. All baseline correlations between HVLT-R and CogState tests were significant (p </= 0.003). At baseline, both CogState tests and one component of HVLT-R differentiated those who were alive at 6 months and those who had died (p </= 0.01). At 4 months, mean relative decline was 7.0 % for HVLT-R Delayed Recall and 18.0 % for ISLT Delayed Recall. OCLT showed an 8.0 % increase. A reliable change index found no significant changes from baseline to 2 and 4 months for ISLT Delayed Recall (z = -0.40, p = 0.34; z = -0.68, p = 0.25) or OCLT (z = 0.15, p = 0.56; z = 0.41, p = 0.66). Study findings support the possibility that hippocampal avoidance may be associated with preservation of memory test performance, and that these computerized tests also may be useful and valid memory assessments in multi-institution adult brain tumor trials.  
  Address Department of Radiation Oncology, Boston Medical Center MBCCOP, 830 Harrison Avenue, Boston, MA, 02118, USA  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0167-594X ISBN Medium  
  Area Expedition Conference  
  Notes PMID:26511494 Approved no  
  Call Number ref @ user @ Serial 92382  
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Author (up) Calado, L.B.; Ferriolli, E.; Moriguti, J.C.; Martinez, E.Z.; Lima, N.K. da C. url  doi
openurl 
  Title Frailty syndrome in an independent urban population in Brazil (FIBRA study): a cross-sectional populational study Type Journal Article
  Year 2016 Publication Sao Paulo Medical Journal = Revista Paulista de Medicina Abbreviated Journal Sao Paulo Med J  
  Volume Issue Pages  
  Keywords  
  Abstract CONTEXT AND OBJECTIVE:: Frailty is a multifactorial syndrome. The aim of this study was to determine the prevalence and characteristics of frailty syndrome in an elderly urban population. DESIGN AND SETTING:: Cross-sectional study carried out at the homes of a randomized sample representing the independent elderly individuals of Ribeirao Preto, Brazil. METHODS:: Sociodemographic characteristics, clinical data and criteria of the frailty phenotype were obtained at the subjects' homes; 385 individuals were evaluated. Frailty was defined based on detection of weight loss, exhaustion, weakness, slowness and low physical activity level. Individuals with three or more of these characteristics were classified as frail and those with one or two as pre-frail. Specific cutoff points for weakness, slowness and low physical activity level were calculated. RESULTS:: The participants' mean age was 73.9 +/- 6.5 years, and 64.7% were women. 12.5% had lost weight over the last year; 20.5% showed exhaustion, 17.1% slowness, 24.4% low physical activity level and 20.5% weakness. 9.1% were considered frail and 49.6% pre-frail. Frail subjects were older, attended more medical visits, had a higher chance of hospitalization within the last 12 months and had more cerebrovascular events, diabetes, neoplasms, osteoporosis and urinary and fecal incontinence. CONCLUSION:: In this independent elderly population, there were numerous frail and pre-frail individuals. Frailty syndrome was associated with high morbidity. Cutoff points for weakness, slowness and low physical activity level should be adjusted for the population under study. It is essential to identify frail and pre-frail older individuals for appropriate interventions.  
  Address MD, PhD. Associate Professor, Division of General Internal Medicine and Geriatrics, Department of Internal Medicine, Faculdade de Medicina de Ribeirao Preto (FMRP), Universidade de Sao Paulo (USP), Ribeirao Preto, SP, Brazil  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1516-3180 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:27657509 Approved no  
  Call Number ref @ user @ Serial 98045  
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Author (up) Camargo, C. de Q.; Mocellin, M.C.; Pastore Silva, J. de A.; Fabre, M.E. de S.; Nunes, E.A.; Trindade, E.B.S. de M. url  doi
openurl 
  Title Fish oil supplementation during chemotherapy increases posterior time to tumor progression in colorectal cancer Type Journal Article
  Year 2016 Publication Nutrition and Cancer Abbreviated Journal Nutr Cancer  
  Volume 68 Issue 1 Pages 70-76  
  Keywords  
  Abstract The authors evaluated clinical outcomes during and after chemotherapy in colorectal cancer patients supplemented with fish oil during the first 9 wk of treatment. Thirty individuals never submitted to chemotherapy were randomized into supplemented group (SG), which received 2 g/day of fish oil (0.6 g/day of EPA and DHA) for 9 wk or control group (CG), which received neither fish oil nor placebo. Outcomes assessed were number of chemotherapy cycles administered; days undergoing chemotherapy; number of delays and interruptions in the administration of chemotherapy; number of hospitalizations during chemotherapy; tumor progression; values of carcinoembryonic antigen (CEA); days until events (death and progression); and 3 yr survival. Time to tumor progression was significantly longer in SG [S593 days (+/-211.5)] vs. CG [330 days (+/- 135.1); P = 0.04], other outcomes did not differ between groups. Subjects with advanced cancer who received fish oil presented longer time to tumor progression and lower CEA values after chemotherapy; however these differences were not statistically significant. Supplementation with 2 g/day of fish oil for the first 9 wk of chemotherapy may contribute to delay in tumor progression in colorectal patients, possibly by enhancing the antineoplastic action of the chemotherapeutic drug.  
  Address c Oncology Research Center , Florianopolis , Santa Catarina , Brazil  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0163-5581 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:26700096 Approved no  
  Call Number ref @ user @ Serial 92600  
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Author (up) Campos, R. de O.; Reboucas, S.C.L.; Beck, R.; de Jesus, L.R.M.; Ramos, Y.R.; Barreto, I.D.S.; Marques, T.X.; Cerqueira, T.L.O.; Santos, W.A.; Oliveira, C.A.; Teixeira, L.S.G.; Souza, V.C. de O.; Barbosa, F.J.; Ramos, H.E. url  doi
openurl 
  Title Iodine Nutritional Status in Schoolchildren from Public Schools in Brazil: A Cross-Sectional Study Exposes Association with Socioeconomic Factors and Food Insecurity Type Journal Article
  Year 2016 Publication Thyroid : Official Journal of the American Thyroid Association Abbreviated Journal Thyroid  
  Volume 26 Issue 7 Pages 972-979  
  Keywords  
  Abstract INTRODUCTION: National programs of salt iodization were implemented in Brazil to combat iodine deficiency (ID) in children of school age. Currently, there are limited data in Brazil on those still vulnerable to this deficiency and the state of nutritional iodine status in the northeast region of Brazil, where children are vulnerable to malnutrition. OBJECTIVE: The aim of this study was to analyze the iodine nutritional status, household food insecurity, socioeconomic and demographic characteristics among schoolchildren from the public school system living in state the state of Bahia, Brazil. METHODS: A cross-sectional study was conducted on 1419 schoolchildren in Bahia between the ages of 6 and 14 years old. Anthropometric parameters, urinary iodine concentrations (UIC), and thyrotropin (TSH) measurements were evaluated from blood spots on filter paper. RESULTS: The mean UIC was 206.4 +/- 80.5 mug/L, with a median of 221.6 mug/L, indicating sufficient iodine intake in the region. Low urinary iodide concentration (<100 mug/L) was detected in 12.3% of the schoolchildren (n = 174), with 6.2% with mild (<100 mug/L), 3.0% with moderate (20-49 mug/L), and 3.1% with severe ID (<20 mug/L). Moreover, 9.4% (n = 134) had a urinary iodide concentration of >300 mug/L, indicating the coexistence of excessive iodine intake (EII). The mean TSH was 1.0 +/- 0.6 mIU/L. The body mass index category “overweight/obesity” was a protective factor against EII (odds ratio [OR] = 0.64 [confidence interval (CI) 0.4-1.0]; p = 0.07). Urban areas (73%) had a mean UIC of 213.1 +/- 80 mug/L compared with 176.8 +/- 76.1 mug/L in rural areas. The risk for EII increased in children living in a house with more than six people (OR = 1.62 [CI 0.9-2.6]; p < 0.05) and water consumption from shallow wells (OR = 1.70 [CI 0.9-3.1]; p = 0.09). The risk of ID was increased by 70% in schoolchildren who had moderate or severe food insecurity (OR = 1.70 [CI 0.9-3.0]; p > 0.05). CONCLUSION: A significant proportion of schoolchildren still have ID or EII in the northeast region of Brazil, emphasizing the importance of committed public policies to address this problem. Socioeconomic factors and the lack of education about nutritional importance of iodine were important influencing factors in the presence of ID in schoolchildren.  
  Address 2 Postgraduate Program in Interactive Processes of Organs and Systems, Health and Science Institute, Federal University of Bahia , Salvador, Brazil  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1050-7256 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:27184190 Approved no  
  Call Number ref @ user @ Serial 98052  
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Author (up) Cardona Arango, D.; Medina-Perez, O.A.; Cardona Duque, D.V. url  doi
openurl 
  Title [Characterisation of Suicide in Colombia, 2000 2010] Type Observational Study
  Year 2016 Publication Revista Colombiana de Psiquiatria Abbreviated Journal Rev Colomb Psiquiatr  
  Volume 45 Issue 3 Pages 170-177  
  Keywords Adolescent; Adult; Aged; Aged, 80 and over; Child; Colombia/epidemiology; Female; Humans; Male; Middle Aged; Suicide/*statistics & numerical data/trends; Young Adult; *Colombia; *Factores de riesgo; *Mortalidad; *Mortality; *Risk factors; *Suicide; *Suicidio  
  Abstract INTRODUCTION: Suicide is a serious public health problem worldwide, affecting all population groups, regardless of age, gender, or area of residence. The aim of this investigation was to characterise the recorded suicides in Colombia, between the years 2000 and 2010, according to the variables of the person, time and place. METHODS: Descriptive quantitative study with information from secondary sources, from the death certificates of deceased people by suicide registered with the National Bureau of Statistics. The behaviour of the deaths and mortality, were determined using the denominator population projections of Colombia and the Amazon, Andean, Atlantic Coast, Eastern Plains and Pacific regions. Descriptive measurements and mortality rates were calculated using these. RESULTS: A total of 24,882 suicides were recorded in the eleven years studied, with a mean of 6.2 people per day, which increased to 8.0 during holidays The mean age of death was 34.5 years (men 36.4, women 27.7), with male deaths (78.1%) and urban areas (66%) predominating. The greatest risk of dying from this cause was recorded in the Eastern Plains, in young adults and seniors, and residents in rural areas. CONCLUSIONS: Suicide rates in Colombia show a downward trend, with a mean of 5.3/100,000 inhabitants, and with an increased risk in men (3.7 times the risk in women, in young adults (9/100,000). A higher death rate was recorded in single people in the months of December and January, and at weekends.  
  Address Docente investigadora, Universidad de San Buenaventura, Seccional Medellin, Medellin, Colombia  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Spanish Summary Language Original Title Caracterizacion del suicidio en Colombia, 2000-2010  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0034-7450 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:27569011 Approved no  
  Call Number ref @ user @ Serial 97668  
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