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Author  |
Antiporta, D.A.; Smeeth, L.; Gilman, R.H.; Miranda, J.J. |
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Title |
Length of urban residence and obesity among within-country rural-to-urban Andean migrants |
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Journal Article |
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Year |
2016 |
Publication |
Public Health Nutrition |
Abbreviated Journal |
Public Health Nutr |
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Volume |
19 |
Issue |
7 |
Pages |
1270-1278 |
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Keywords |
Adipose Tissue/metabolism; Adolescent; Adult; Aged; Child; Child, Preschool; Cross-Sectional Studies; Female; Humans; Infant; Linear Models; Male; Middle Aged; Multivariate Analysis; Obesity/*epidemiology; Peru/epidemiology; Prevalence; *Residence Characteristics; Risk Factors; *Rural Population; Sensitivity and Specificity; Socioeconomic Factors; Time Factors; Transients and Migrants; *Urban Population; Young Adult; Migration; Nutritional epidemiology; Obesity; Peru; Rural-to-urban; Skinfold |
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Abstract |
OBJECTIVE: To evaluate the association between length of residence in an urban area and obesity among Peruvian rural-to-urban migrants. DESIGN: Cross-sectional database analysis of the migrant group from the PERU MIGRANT Study (2007). Exposure was length of urban residence, analysed as both a continuous (10-year units) and a categorical variable. Four skinfold site measurements (biceps, triceps, subscapular and suprailiac) were used to calculate body fat percentage and obesity (body fat percentage >25% males, >33% females). We used Poisson generalized linear models to estimate adjusted prevalence ratios and 95 % confidence intervals. Multicollinearity between age and length of urban residence was assessed using conditional numbers and correlation tests. SETTING: A peri-urban shantytown in the south of Lima, Peru. SUBJECTS: Rural-to-urban migrants (n 526) living in Lima. RESULTS: Multivariable analyses showed that for each 10-year unit increase in residence in an urban area, rural-to-urban migrants had, on average, a 12 % (95 % CI 6, 18 %) higher prevalence of obesity. This association was also present when length of urban residence was analysed in categories. Sensitivity analyses, conducted with non-migrant groups, showed no evidence of an association between 10-year age units and obesity in rural (P=0.159) or urban populations (P=0.078). High correlation and a large conditional number between age and length of urban residence were found, suggesting a strong collinearity between both variables. CONCLUSIONS: Longer lengths of urban residence are related to increased obesity in rural-to-urban migrant populations; therefore, interventions to prevent obesity in urban areas may benefit from targeting migrant groups. |
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1CRONICAS Center of Excellence in Chronic Diseases,Universidad Peruana Cayetano Heredia,Av. Armendariz 497,Miraflores,Lima 18,Peru |
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1368-9800 |
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PMID:26365215 |
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Call Number |
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Serial |
97696 |
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Author |
Aoyagi, S.; Oda, T.; Fukuda, H.; Zaima, Y.; Nakamura, E.; Yasunaga, H. |
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Title |
Isolated Tricuspid Valve Endocarditis Caused by Infection of an Implanted Central Venous Access Port Device |
Type |
Journal Article |
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Year |
2016 |
Publication |
The Kurume Medical Journal |
Abbreviated Journal |
Kurume Med J |
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Volume |
62 |
Issue |
1-2 |
Pages |
37-40 |
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Keywords |
Aged; Anti-Bacterial Agents/therapeutic use; Cardiac Valve Annuloplasty; Catheter-Related Infections/diagnosis/drug therapy/*microbiology; Catheterization, Central Venous/*adverse effects/*instrumentation; Catheters, Indwelling/*adverse effects; Central Venous Catheters/*adverse effects; Echocardiography, Doppler; Endocarditis, Bacterial/diagnostic imaging/*microbiology/therapy; Heart Valve Prosthesis Implantation; Humans; Male; Methicillin-Resistant Staphylococcus aureus/drug effects/*isolation & purification; Staphylococcal Infections/diagnosis/drug therapy/*microbiology; Treatment Outcome; Tricuspid Valve/diagnostic imaging/*microbiology/surgery |
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A 70-year-old man was referred to our hospital for an intermittent high fever attributed to subcutaneous pocket infection of an implanted central venous access port device caused by methicillin-resistant staphylococcus aureus and subsequent bloodstream infection. Echocardiography revealed a large vegetation on the posterior tricuspid leaflet, annular dilatation and moderate-to-severe tricuspid regurgitation. Valve surgery was performed for persistent infection despite 8 weeks of antibiotics therapy. At operation, vegetations and torn chordae tendineae were found on the posterior tricuspid leaflet. After total resection of the posterior tricuspid leaflet, bicuspidalization valvuloplasty with prosthetic ring annuloplasty was achieved without relapse of the infection or residual regurgitation. |
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Department of Cardiovascular Surgery, St. Mary's Hospital |
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0023-5679 |
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PMID:26935569 |
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Call Number |
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98520 |
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Author |
Aoyagi, S.; Oda, T.; Fukuda, H.; Zaima, Y.; Nakamura, E.; Yasunaga, H. |
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Title |
Isolated Tricuspid Valve Endocarditis Caused by Infection of an Implanted Central Venous Access Port Device |
Type |
Journal Article |
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Year |
2016 |
Publication |
The Kurume Medical Journal |
Abbreviated Journal |
Kurume Med J |
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Volume |
62 |
Issue |
1-2 |
Pages |
37-40 |
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Keywords |
Aged; Anti-Bacterial Agents/therapeutic use; Cardiac Valve Annuloplasty; Catheter-Related Infections/diagnosis/drug therapy/*microbiology; Catheterization, Central Venous/*adverse effects/*instrumentation; Catheters, Indwelling/*adverse effects; Central Venous Catheters/*adverse effects; Echocardiography, Doppler; Endocarditis, Bacterial/diagnostic imaging/*microbiology/therapy; Heart Valve Prosthesis Implantation; Humans; Male; Methicillin-Resistant Staphylococcus aureus/drug effects/*isolation & purification; Staphylococcal Infections/diagnosis/drug therapy/*microbiology; Treatment Outcome; Tricuspid Valve/diagnostic imaging/*microbiology/surgery |
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Abstract |
A 70-year-old man was referred to our hospital for an intermittent high fever attributed to subcutaneous pocket infection of an implanted central venous access port device caused by methicillin-resistant staphylococcus aureus and subsequent bloodstream infection. Echocardiography revealed a large vegetation on the posterior tricuspid leaflet, annular dilatation and moderate-to-severe tricuspid regurgitation. Valve surgery was performed for persistent infection despite 8 weeks of antibiotics therapy. At operation, vegetations and torn chordae tendineae were found on the posterior tricuspid leaflet. After total resection of the posterior tricuspid leaflet, bicuspidalization valvuloplasty with prosthetic ring annuloplasty was achieved without relapse of the infection or residual regurgitation. |
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Department of Cardiovascular Surgery, St. Mary's Hospital |
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0023-5679 |
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Notes |
PMID:26935569 |
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Call Number |
ref @ user @ |
Serial |
99550 |
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Author |
Arita, H.; Yamasaki, K.; Matsushita, Y.; Nakamura, T.; Shimokawa, A.; Takami, H.; Tanaka, S.; Mukasa, A.; Shirahata, M.; Shimizu, S.; Suzuki, K.; Saito, K.; Kobayashi, K.; Higuchi, F.; Uzuka, T.; Otani, R.; Tamura, K.; Sumita, K.; Ohno, M.; Miyakita, Y.; Kagawa, N.; Hashimoto, N.; Hatae, R.; Yoshimoto, K.; Shinojima, N.; Nakamura, H.; Kanemura, Y.; Okita, Y.; Kinoshita, M.; Ishibashi, K.; Shofuda, T.; Kodama, Y.; Mori, K.; Tomogane, Y.; Fukai, J.; Fujita, K.; Terakawa, Y.; Tsuyuguchi, N.; Moriuchi, S.; Nonaka, M.; Suzuki, H.; Shibuya, M.; Maehara, T.; Saito, N.; Nagane, M.; Kawahara, N.; Ueki, K.; Yoshimine, T.; Miyaoka, E.; Nishikawa, R.; Komori, T.; Narita, Y.; Ichimura, K. |
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Title |
A combination of TERT promoter mutation and MGMT methylation status predicts clinically relevant subgroups of newly diagnosed glioblastomas |
Type |
Journal Article |
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Year |
2016 |
Publication |
Acta Neuropathologica Communications |
Abbreviated Journal |
Acta Neuropathol Commun |
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Volume |
4 |
Issue |
1 |
Pages |
79 |
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Keywords |
1p19q; Glioblastoma; Glioma; Idh1/2; Molecular classification; Prognostic factor; Tert; Temozolomide |
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Abstract |
The prognostic impact of TERT mutations has been controversial in IDH-wild tumors, particularly in glioblastomas (GBM). The controversy may be attributable to presence of potential confounding factors such as MGMT methylation status or patients' treatment. This study aimed to evaluate the impact of TERT status on patient outcome in association with various factors in a large series of adult diffuse gliomas. We analyzed a total of 951 adult diffuse gliomas from two cohorts (Cohort 1, n = 758; Cohort 2, n = 193) for IDH1/2, 1p/19q, and TERT promoter status. The combined IDH/TERT classification divided Cohort 1 into four molecular groups with distinct outcomes. The overall survival (OS) was the shortest in IDH wild-type/TERT mutated groups, which mostly consisted of GBMs (P < 0.0001). To investigate the association between TERT mutations and MGMT methylation on survival of patients with GBM, samples from a combined cohort of 453 IDH-wild-type GBM cases treated with radiation and temozolomide were analyzed. A multivariate Cox regression model revealed that the interaction between TERT and MGMT was significant for OS (P = 0.0064). Compared with TERT mutant-MGMT unmethylated GBMs, the hazard ratio (HR) for OS incorporating the interaction was the lowest in the TERT mutant-MGMT methylated GBM (HR, 0.266), followed by the TERT wild-type-MGMT methylated (HR, 0.317) and the TERT wild-type-MGMT unmethylated GBMs (HR, 0.542). Thus, patients with TERT mutant-MGMT unmethylated GBM have the poorest prognosis. Our findings suggest that a combination of IDH, TERT, and MGMT refines the classification of grade II-IV diffuse gliomas. |
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Division of Brain Tumor Translational Research, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan. kichimur@ncc.go.jp |
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2051-5960 |
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PMID:27503138 |
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Call Number |
ref @ user @ |
Serial |
96639 |
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Author |
Autor |
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Título |
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Journal Article |
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Year |
2016 |
Publication |
Ascar |
Abbreviated Journal |
JMN |
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Volume |
12 |
Issue |
54 |
Pages |
13 |
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Keywords |
numeral, letra, matemática, portugês |
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Abstract |
Resumo de teste desta ferramenta de organização bibliográfca. |
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ref @ user @ |
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92349 |
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