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Author Gomez, F.; Corchuelo, J.; Curcio, C.-L.; Calzada, M.-T.; Mendez, F. url  doi
openurl 
  Title SABE Colombia: Survey on Health, Well-Being, and Aging in Colombia-Study Design and Protocol Type Journal Article
  Year 2016 Publication Current Gerontology and Geriatrics Research Abbreviated Journal Curr Gerontol Geriatr Res  
  Volume 2016 Issue Pages (down) 7910205  
  Keywords  
  Abstract Objective. To describe the design of the SABE Colombia study. The major health study of the old people in Latin America and the Caribbean (LAC) is the Survey on Health, Well-Being, and Aging in LAC, SABE (from initials in Spanish: SAlud, Bienestar & Envejecimiento). Methods. The SABE Colombia is a population-based cross-sectional study on health, aging, and well-being of elderly individuals aged at least 60 years focusing attention on social determinants of health inequities. Methods and design were similar to original LAC SABE. The total sample size of the study at the urban and rural research sites (244 municipalities) was 23.694 elderly Colombians representative of the total population. The study had three components: (1) a questionnaire covering active aging determinants including anthropometry, blood pressure measurement, physical function, and biochemical and hematological measures; (2) a subsample survey among family caregivers; (3) a qualitative study with gender and cultural perspectives of quality of life to understand different dimensions of people meanings. Conclusions. The SABE Colombia is a comprehensive, multidisciplinary study of the elderly with respect to active aging determinants. The results of this study are intended to inform public policies aimed at tackling health inequalities for the aging society in Colombia.  
  Address Escuela de Salud Publica, Universidad del Valle, Research Group of Epidemiology and Population Health (GEPH), Cali, Colombia  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1687-7063 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:27956896 Approved no  
  Call Number ref @ user @ Serial 97126  
Permanent link to this record
 

 
Author Gomez, F.; Corchuelo, J.; Curcio, C.-L.; Calzada, M.-T.; Mendez, F. url  doi
openurl 
  Title SABE Colombia: Survey on Health, Well-Being, and Aging in Colombia-Study Design and Protocol Type Journal Article
  Year 2016 Publication Current Gerontology and Geriatrics Research Abbreviated Journal Curr Gerontol Geriatr Res  
  Volume 2016 Issue Pages (down) 7910205  
  Keywords  
  Abstract Objective. To describe the design of the SABE Colombia study. The major health study of the old people in Latin America and the Caribbean (LAC) is the Survey on Health, Well-Being, and Aging in LAC, SABE (from initials in Spanish: SAlud, Bienestar & Envejecimiento). Methods. The SABE Colombia is a population-based cross-sectional study on health, aging, and well-being of elderly individuals aged at least 60 years focusing attention on social determinants of health inequities. Methods and design were similar to original LAC SABE. The total sample size of the study at the urban and rural research sites (244 municipalities) was 23.694 elderly Colombians representative of the total population. The study had three components: (1) a questionnaire covering active aging determinants including anthropometry, blood pressure measurement, physical function, and biochemical and hematological measures; (2) a subsample survey among family caregivers; (3) a qualitative study with gender and cultural perspectives of quality of life to understand different dimensions of people meanings. Conclusions. The SABE Colombia is a comprehensive, multidisciplinary study of the elderly with respect to active aging determinants. The results of this study are intended to inform public policies aimed at tackling health inequalities for the aging society in Colombia.  
  Address Escuela de Salud Publica, Universidad del Valle, Research Group of Epidemiology and Population Health (GEPH), Cali, Colombia  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1687-7063 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:27956896 Approved no  
  Call Number ref @ user @ Serial 97337  
Permanent link to this record
 

 
Author Mohan, K.N. url  doi
openurl 
  Title Stem Cell Models to Investigate the Role of DNA Methylation Machinery in Development of Neuropsychiatric Disorders Type Journal Article
  Year 2016 Publication Stem Cells International Abbreviated Journal Stem Cells Int  
  Volume 2016 Issue Pages (down) 4379425  
  Keywords  
  Abstract Epigenetic mechanisms underlie differentiation of pluripotent stem cells into different lineages that contain identical genomes but express different sets of cell type-specific genes. Because of high discordance rates in monozygotic twins, epigenetic mechanisms are also implicated in development of neuropsychiatric disorders such as schizophrenia and autism. In support of this notion, increased levels of DNA methyltransferases (DNMTs), DNMT polymorphisms, and dysregulation of DNA methylation network were reported among schizophrenia patients. These results point to the importance of development of DNA methylation machinery-based models for studying the mechanism of abnormal neurogenesis due to certain DNMT alleles or dysregulated DNMTs. Achieving this goal is strongly confronted by embryonic lethality associated with altered levels of epigenetic machinery such as DNMT1 and expensive approaches in developing in vivo models. In light of literature evidence that embryonic stem cells (ESCs) are tolerant of DNMT mutations and advancement in the technology of gene targeting, it is now possible to introduce desired mutations in DNMT loci to generate suitable ESC lines that can help understand the underlying mechanisms by which abnormal levels of DNMTs or their specific mutations/alleles result in abnormal neurogenesis. In the future, these models can facilitate development of suitable drugs for treatment of neuropsychiatric disorders.  
  Address Department of Biological Sciences, Birla Institute of Technology and Science, Pilani, Hyderabad Campus, Jawaharnagar, Hyderabad 500 078, India  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1687-966X ISBN Medium  
  Area Expedition Conference  
  Notes PMID:26798355 Approved no  
  Call Number ref @ user @ Serial 95979  
Permanent link to this record
 

 
Author Weick, J.P. url  doi
openurl 
  Title Functional Properties of Human Stem Cell-Derived Neurons in Health and Disease Type Journal Article
  Year 2016 Publication Stem Cells International Abbreviated Journal Stem Cells Int  
  Volume 2016 Issue Pages (down) 4190438  
  Keywords  
  Abstract Stem cell-derived neurons from various source materials present unique model systems to examine the fundamental properties of central nervous system (CNS) development as well as the molecular underpinnings of disease phenotypes. In order to more accurately assess potential therapies for neurological disorders, multiple strategies have been employed in recent years to produce neuronal populations that accurately represent in vivo regional and transmitter phenotypes. These include new technologies such as direct conversion of somatic cell types into neurons and glia which may accelerate maturation and retain genetic hallmarks of aging. In addition, novel forms of genetic manipulations have brought human stem cells nearly on par with those of rodent with respect to gene targeting. For neurons of the CNS, the ultimate phenotypic characterization lies with their ability to recapitulate functional properties such as passive and active membrane characteristics, synaptic activity, and plasticity. These features critically depend on the coordinated expression and localization of hundreds of ion channels and receptors, as well as scaffolding and signaling molecules. In this review I will highlight the current state of knowledge regarding functional properties of human stem cell-derived neurons, with a primary focus on pluripotent stem cells. While significant advances have been made, critical hurdles must be overcome in order for this technology to support progression toward clinical applications.  
  Address Department of Neurosciences, University of New Mexico Health Science Center, Fitz Hall Room 145, 915 Camino de Salud NE, Albuquerque, NM 87131, USA  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1687-966X ISBN Medium  
  Area Expedition Conference  
  Notes PMID:27274733 Approved no  
  Call Number ref @ user @ Serial 95947  
Permanent link to this record
 

 
Author Pfaender, S.; Fohr, K.; Lutz, A.-K.; Putz, S.; Achberger, K.; Linta, L.; Liebau, S.; Boeckers, T.M.; Grabrucker, A.M. url  doi
openurl 
  Title Cellular Zinc Homeostasis Contributes to Neuronal Differentiation in Human Induced Pluripotent Stem Cells Type Journal Article
  Year 2016 Publication Neural Plasticity Abbreviated Journal Neural Plast  
  Volume 2016 Issue Pages (down) 3760702  
  Keywords Apoptosis/physiology; Cell Survival/physiology; Homeostasis/*physiology; Humans; Induced Pluripotent Stem Cells/cytology/*metabolism; Neurogenesis/*physiology; Neurons/cytology/*metabolism; Signal Transduction/physiology; Zinc/*metabolism  
  Abstract Disturbances in neuronal differentiation and function are an underlying factor of many brain disorders. Zinc homeostasis and signaling are important mediators for a normal brain development and function, given that zinc deficiency was shown to result in cognitive and emotional deficits in animal models that might be associated with neurodevelopmental disorders. One underlying mechanism of the observed detrimental effects of zinc deficiency on the brain might be impaired proliferation and differentiation of stem cells participating in neurogenesis. Thus, to examine the molecular mechanisms regulating zinc metabolism and signaling in differentiating neurons, using a protocol for motor neuron differentiation, we characterized the expression of zinc homeostasis genes during neurogenesis using human induced pluripotent stem cells (hiPSCs) and evaluated the influence of altered zinc levels on the expression of zinc homeostasis genes, cell survival, cell fate, and neuronal function. Our results show that zinc transporters are highly regulated genes during neuronal differentiation and that low zinc levels are associated with decreased cell survival, altered neuronal differentiation, and, in particular, synaptic function. We conclude that zinc deficiency in a critical time window during brain development might influence brain function by modulating neuronal differentiation.  
  Address Institute for Anatomy and Cell Biology, Ulm University, 89081 Ulm, Germany; WG Molecular Analysis of Synaptopathies, Neurology Department, Neurocenter of Ulm University, 89081 Ulm, Germany  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1687-5443 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:27247802 Approved no  
  Call Number ref @ user @ Serial 95949  
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