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Author Kaufman, D. url  doi
openurl 
  Title Umbilical catheter removal and bloodstream infections: 'A case of too many antibiotics' Type Journal Article
  Year 2016 Publication (up) Acta Paediatrica (Oslo, Norway : 1992) Abbreviated Journal Acta Paediatr  
  Volume 105 Issue 4 Pages 343-345  
  Keywords Anti-Bacterial Agents/*therapeutic use; Bacteremia/drug therapy; Catheter-Related Infections; *Catheterization, Central Venous; Humans; Vascular Access Devices  
  Abstract  
  Address Division of Neonatology, Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, VA, USA. dak4r@virginia.edu  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0803-5253 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:26946235 Approved no  
  Call Number ref @ user @ Serial 98987  
Permanent link to this record
 

 
Author Lindquist, S.; Hentz, E.; Tessin, I.; Elfvin, A. url  doi
openurl 
  Title Very low birthweight infants face an increased risk of bloodstream infections following the removal of umbilical catheters Type Journal Article
  Year 2016 Publication (up) Acta Paediatrica (Oslo, Norway : 1992) Abbreviated Journal Acta Paediatr  
  Volume 105 Issue 4 Pages 391-396  
  Keywords Bacteremia/*etiology; Catheters/*adverse effects; Humans; Infant, Newborn; Infant, Very Low Birth Weight; Retrospective Studies; Umbilicus/surgery; Central venous catheter; Low birthweight infants; Neonatal septicaemia; Preterm infant; Umbilical artery catheter  
  Abstract AIM: This study examined whether there was a temporal association between removing umbilical catheters and bloodstream infections (BSI) in a neonatal intensive care unit, as this is an area of research that has not received sufficient attention. METHODS: We carried out a retrospective study of all neonates receiving umbilical catheters during 2011 and 2012 in the neonatal intensive care unit at Sahlgrenska University Hospital, Gothenburg, Sweden. The time from umbilical catheter removals to the first subsequent BSI was recorded. RESULTS: A total of 372 infants had umbilical catheters inserted and 146 of these had a birthweight of <1500 g. Antibiotics were discontinued when umbilical catheters were removed in 67 of these low birthweight infants and 20 of them needed to be retreated for BSI within 72 hours. We found that very low birthweight infants had a significantly increased risk of developing BSI if antibiotics were discontinued at the same time as umbilical catheters were removed, rather than being continued after removal (p < 0.001). CONCLUSION: This NICU study demonstrated a temporal association between removing umbilical catheters and BSI in very low birthweight infants weighting <1500 g.  
  Address Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0803-5253 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:26461802 Approved no  
  Call Number ref @ user @ Serial 99077  
Permanent link to this record
 

 
Author Kaufman, D. url  doi
openurl 
  Title Umbilical catheter removal and bloodstream infections: 'A case of too many antibiotics' Type Journal Article
  Year 2016 Publication (up) Acta Paediatrica (Oslo, Norway : 1992) Abbreviated Journal Acta Paediatr  
  Volume 105 Issue 4 Pages 343-345  
  Keywords Anti-Bacterial Agents/*therapeutic use; Bacteremia/drug therapy; Catheter-Related Infections; *Catheterization, Central Venous; Humans; Vascular Access Devices  
  Abstract  
  Address Division of Neonatology, Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, VA, USA. dak4r@virginia.edu  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0803-5253 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:26946235 Approved no  
  Call Number ref @ user @ Serial 100017  
Permanent link to this record
 

 
Author Lindquist, S.; Hentz, E.; Tessin, I.; Elfvin, A. url  doi
openurl 
  Title Very low birthweight infants face an increased risk of bloodstream infections following the removal of umbilical catheters Type Journal Article
  Year 2016 Publication (up) Acta Paediatrica (Oslo, Norway : 1992) Abbreviated Journal Acta Paediatr  
  Volume 105 Issue 4 Pages 391-396  
  Keywords Bacteremia/*etiology; Catheters/*adverse effects; Humans; Infant, Newborn; Infant, Very Low Birth Weight; Retrospective Studies; Umbilicus/surgery; Central venous catheter; Low birthweight infants; Neonatal septicaemia; Preterm infant; Umbilical artery catheter  
  Abstract AIM: This study examined whether there was a temporal association between removing umbilical catheters and bloodstream infections (BSI) in a neonatal intensive care unit, as this is an area of research that has not received sufficient attention. METHODS: We carried out a retrospective study of all neonates receiving umbilical catheters during 2011 and 2012 in the neonatal intensive care unit at Sahlgrenska University Hospital, Gothenburg, Sweden. The time from umbilical catheter removals to the first subsequent BSI was recorded. RESULTS: A total of 372 infants had umbilical catheters inserted and 146 of these had a birthweight of <1500 g. Antibiotics were discontinued when umbilical catheters were removed in 67 of these low birthweight infants and 20 of them needed to be retreated for BSI within 72 hours. We found that very low birthweight infants had a significantly increased risk of developing BSI if antibiotics were discontinued at the same time as umbilical catheters were removed, rather than being continued after removal (p < 0.001). CONCLUSION: This NICU study demonstrated a temporal association between removing umbilical catheters and BSI in very low birthweight infants weighting <1500 g.  
  Address Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0803-5253 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:26461802 Approved no  
  Call Number ref @ user @ Serial 100107  
Permanent link to this record
 

 
Author Burbulla, L.F.; Beaumont, K.G.; Mrksich, M.; Krainc, D. url  doi
openurl 
  Title Micropatterning Facilitates the Long-Term Growth and Analysis of iPSC-Derived Individual Human Neurons and Neuronal Networks Type Journal Article
  Year 2016 Publication (up) Advanced Healthcare Materials Abbreviated Journal Adv Healthc Mater  
  Volume 5 Issue 15 Pages 1894-1903  
  Keywords aging; human induced pluripotent stem cells; long-term neuronal culture; microcontact printing technology; neurodegenerative disorders  
  Abstract The discovery of induced pluripotent stem cells (iPSCs) and their application to patient-specific disease models offers new opportunities for studying the pathophysiology of neurological disorders. However, current methods for culturing iPSC-derived neuronal cells result in clustering of neurons, which precludes the analysis of individual neurons and defined neuronal networks. To address this challenge, cultures of human neurons on micropatterned surfaces are developed that promote neuronal survival over extended periods of time. This approach facilitates studies of neuronal development, cellular trafficking, and related mechanisms that require assessment of individual neurons and specific network connections. Importantly, micropatterns support the long-term stability of cultured neurons, which enables time-dependent analysis of cellular processes in living neurons. The approach described in this paper allows mechanistic studies of human neurons, both in terms of normal neuronal development and function, as well as time-dependent pathological processes, and provides a platform for testing of new therapeutics in neuropsychiatric disorders.  
  Address Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 2192-2640 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:27108930 Approved no  
  Call Number ref @ user @ Serial 95960  
Permanent link to this record
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