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Author Wolf, M.; Smith, J.; Proctor, C. url  doi
openurl 
  Title Pharmacy leadership development through national resident collaboration Type Journal Article
  Year 2016 Publication (up) American Journal of Health-System Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists Abbreviated Journal Am J Health Syst Pharm  
  Volume 73 Issue 5 Pages 268-269  
  Keywords *Cooperative Behavior; Humans; Pharmacy/*methods/trends; Pharmacy Residencies/*methods/trends; United States  
  Abstract  
  Address Academic Division Department of PharmacyJohns Hopkins Health SystemBaltimore, MD  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1079-2082 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:26896496 Approved no  
  Call Number ref @ user @ Serial 95085  
Permanent link to this record
 

 
Author Luther, M.K.; Mermel, L.A.; LaPlante, K.L. url  doi
openurl 
  Title Comparison of telavancin and vancomycin lock solutions in eradication of biofilm-producing staphylococci and enterococci from central venous catheters Type Journal Article
  Year 2016 Publication (up) American Journal of Health-System Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists Abbreviated Journal Am J Health Syst Pharm  
  Volume 73 Issue 5 Pages 315-321  
  Keywords Aminoglycosides/*administration & dosage; Anti-Bacterial Agents/administration & dosage; Biofilms/*drug effects; Catheter-Related Infections/diagnosis/*drug therapy; Central Venous Catheters/microbiology; Enterococcus/*drug effects/isolation & purification; Humans; Pharmaceutical Solutions/administration & dosage; Staphylococcus/*drug effects/isolation & purification; Staphylococcus aureus/drug effects/isolation & purification; Staphylococcus epidermidis/drug effects/isolation & purification; Vancomycin/*administration & dosage  
  Abstract PURPOSE: Results of a study of the activity of antibiotic lock solutions of vancomycin and telavancin against biofilm-forming strains of Staphylococcus epidermidis, Enterococcus faecalis, and Staphylococcus aureus are reported. METHODS: An established in vitro central venous catheter model was used to evaluate lock solutions containing vancomycin (5 mg/mL) or telavancin (5 mg/mL), with and without preservative-containing heparin sodium (with 0.45% benzyl alcohol) 2500 units/mL, heparin, and 0.9% sodium chloride solution. Lock solutions were introduced after 24-hour bacterial growth in catheters incubated at 35 degrees C. After 72 hours of exposure to the lock solutions, catheters were drained, flushed, and cut into segments for quantification of colony-forming units. RESULTS: Against S. epidermidis, vancomycin and telavancin (with or without heparin) had similar activity. Against E. faecalis, vancomycin alone was more active than telavancin alone (p < 0.01). Against S. aureus, vancomycin plus heparin had activity similar to that of vancomycin alone; both lock agents had greater activity than telavancin (p < 0.02). The addition of heparin was associated with reduced activity of the vancomycin lock solution against S. epidermidis and E. faecalis (p < 0.01). Telavancin activity was not significantly changed with the addition of heparin. CONCLUSION: In a central venous catheter model, vancomycin and telavancin activity was similar in reducing biofilm-producing S. epidermidis. However, vancomycin was more active than telavancin against E. faecalis and S. aureus. None of the tested agents eradicated biofilm-forming strains. The addition of preservative-containing heparin sodium 2500 units/mL to vancomycin was associated with reduced activity against S. epidermidis and E. faecalis.  
  Address Rhode Island Infectious Diseases Research Program, Providence Veterans Affairs Medical Center, Providence, RI, and Department of Pharmacy Practice, University of Rhode Island, Kingston, RI. kerrylaplante@uri.edu  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1079-2082 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:26896504 Approved no  
  Call Number ref @ user @ Serial 99090  
Permanent link to this record
 

 
Author Luther, M.K.; Mermel, L.A.; LaPlante, K.L. url  doi
openurl 
  Title Comparison of telavancin and vancomycin lock solutions in eradication of biofilm-producing staphylococci and enterococci from central venous catheters Type Journal Article
  Year 2016 Publication (up) American Journal of Health-System Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists Abbreviated Journal Am J Health Syst Pharm  
  Volume 73 Issue 5 Pages 315-321  
  Keywords Aminoglycosides/*administration & dosage; Anti-Bacterial Agents/administration & dosage; Biofilms/*drug effects; Catheter-Related Infections/diagnosis/*drug therapy; Central Venous Catheters/microbiology; Enterococcus/*drug effects/isolation & purification; Humans; Pharmaceutical Solutions/administration & dosage; Staphylococcus/*drug effects/isolation & purification; Staphylococcus aureus/drug effects/isolation & purification; Staphylococcus epidermidis/drug effects/isolation & purification; Vancomycin/*administration & dosage  
  Abstract PURPOSE: Results of a study of the activity of antibiotic lock solutions of vancomycin and telavancin against biofilm-forming strains of Staphylococcus epidermidis, Enterococcus faecalis, and Staphylococcus aureus are reported. METHODS: An established in vitro central venous catheter model was used to evaluate lock solutions containing vancomycin (5 mg/mL) or telavancin (5 mg/mL), with and without preservative-containing heparin sodium (with 0.45% benzyl alcohol) 2500 units/mL, heparin, and 0.9% sodium chloride solution. Lock solutions were introduced after 24-hour bacterial growth in catheters incubated at 35 degrees C. After 72 hours of exposure to the lock solutions, catheters were drained, flushed, and cut into segments for quantification of colony-forming units. RESULTS: Against S. epidermidis, vancomycin and telavancin (with or without heparin) had similar activity. Against E. faecalis, vancomycin alone was more active than telavancin alone (p < 0.01). Against S. aureus, vancomycin plus heparin had activity similar to that of vancomycin alone; both lock agents had greater activity than telavancin (p < 0.02). The addition of heparin was associated with reduced activity of the vancomycin lock solution against S. epidermidis and E. faecalis (p < 0.01). Telavancin activity was not significantly changed with the addition of heparin. CONCLUSION: In a central venous catheter model, vancomycin and telavancin activity was similar in reducing biofilm-producing S. epidermidis. However, vancomycin was more active than telavancin against E. faecalis and S. aureus. None of the tested agents eradicated biofilm-forming strains. The addition of preservative-containing heparin sodium 2500 units/mL to vancomycin was associated with reduced activity against S. epidermidis and E. faecalis.  
  Address Rhode Island Infectious Diseases Research Program, Providence Veterans Affairs Medical Center, Providence, RI, and Department of Pharmacy Practice, University of Rhode Island, Kingston, RI. kerrylaplante@uri.edu  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1079-2082 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:26896504 Approved no  
  Call Number ref @ user @ Serial 100120  
Permanent link to this record
 

 
Author Kraus, M.A.; Kansal, S.; Copland, M.; Komenda, P.; Weinhandl, E.D.; Bakris, G.L.; Chan, C.T.; Fluck, R.J.; Burkart, J.M. url  doi
openurl 
  Title Intensive Hemodialysis and Potential Risks With Increasing Treatment Type Journal Article
  Year 2016 Publication (up) American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation Abbreviated Journal Am J Kidney Dis  
  Volume 68 Issue 5s1 Pages S51-S58  
  Keywords Arteriovenous Shunt, Surgical/adverse effects; Catheterization, Central Venous/adverse effects; Humans; Infection/etiology; Kidney/physiopathology; Kidney Failure, Chronic/mortality/physiopathology/*therapy; Renal Dialysis/*adverse effects/*methods; Risk Factors; *Buttonhole cannulation; *Frequent Hemodialysis Network; *caregiver; *chronic kidney disease; *daily dialysis; *end stage renal disease (ESRD); *home dialysis; *infection; *intensive hemodialysis; *mortality; *nocturnal hemodialysis; *residual renal function; *review; *short daily hemodialysis; *survival; *technique failure; *vascular access  
  Abstract Although intensive hemodialysis (HD) can address important clinical problems, increasing treatment also introduces risks. In this review, we assess risks pertaining to 6 domains: vascular access complications, infection, mortality, loss of residual kidney function, solute balance, and patient and care partner burden. In the Frequent Hemodialysis Network (FHN) trials, short daily and nocturnal schedules increased the incidence of access complications, although the incidence of access loss was not statistically higher. Observational studies indicate that infection-related hospitalization is an ongoing challenge with short daily HD. Excess risk may be catalyzed by poor infection control practices in the home setting in which intensive HD is typically delivered, but with fixed probability of bacterial contamination per cannulation, greater treatment frequency necessarily increases the risk for infectious complications. Buttonhole cannulation may increase the risk for metastatic infections. However, intensive HD in the home setting is associated with lower risk for infection than peritoneal dialysis. Data regarding mortality are equivocal. With extended follow-up of individuals in the FHN trials, short daily HD was associated with lower risk relative to the usual schedule, whereas nocturnal HD was associated with higher risk. In many, but not all, observational studies, short daily HD has been associated with lower risk than both in-center HD and peritoneal dialysis; however, observational studies are subject to unmeasured confounding. Intensive HD can accelerate the loss of residual kidney function in new dialysis patients with substantial urine output and can deplete solutes (eg, phosphorus) to the extent that supplementation is necessary. Finally, intensive HD may increase burden on patients and caregivers, possibly leading to technique failure. Some of these problems might be addressed with careful monitoring, so that relevant interventions (eg, antibiotics, retraining, and respite care) can be delivered. Ultimately, intensive HD is not a panacea for end-stage renal disease. Potential benefits and risks of treatment should be jointly considered.  
  Address Wake Forest University Medical Center, Winston-Salem, NC  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0272-6386 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:27772644 Approved no  
  Call Number ref @ user @ Serial 99016  
Permanent link to this record
 

 
Author Kraus, M.A.; Kansal, S.; Copland, M.; Komenda, P.; Weinhandl, E.D.; Bakris, G.L.; Chan, C.T.; Fluck, R.J.; Burkart, J.M. url  doi
openurl 
  Title Intensive Hemodialysis and Potential Risks With Increasing Treatment Type Journal Article
  Year 2016 Publication (up) American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation Abbreviated Journal Am J Kidney Dis  
  Volume 68 Issue 5s1 Pages S51-S58  
  Keywords Arteriovenous Shunt, Surgical/adverse effects; Catheterization, Central Venous/adverse effects; Humans; Infection/etiology; Kidney/physiopathology; Kidney Failure, Chronic/mortality/physiopathology/*therapy; Renal Dialysis/*adverse effects/*methods; Risk Factors; *Buttonhole cannulation; *Frequent Hemodialysis Network; *caregiver; *chronic kidney disease; *daily dialysis; *end stage renal disease (ESRD); *home dialysis; *infection; *intensive hemodialysis; *mortality; *nocturnal hemodialysis; *residual renal function; *review; *short daily hemodialysis; *survival; *technique failure; *vascular access  
  Abstract Although intensive hemodialysis (HD) can address important clinical problems, increasing treatment also introduces risks. In this review, we assess risks pertaining to 6 domains: vascular access complications, infection, mortality, loss of residual kidney function, solute balance, and patient and care partner burden. In the Frequent Hemodialysis Network (FHN) trials, short daily and nocturnal schedules increased the incidence of access complications, although the incidence of access loss was not statistically higher. Observational studies indicate that infection-related hospitalization is an ongoing challenge with short daily HD. Excess risk may be catalyzed by poor infection control practices in the home setting in which intensive HD is typically delivered, but with fixed probability of bacterial contamination per cannulation, greater treatment frequency necessarily increases the risk for infectious complications. Buttonhole cannulation may increase the risk for metastatic infections. However, intensive HD in the home setting is associated with lower risk for infection than peritoneal dialysis. Data regarding mortality are equivocal. With extended follow-up of individuals in the FHN trials, short daily HD was associated with lower risk relative to the usual schedule, whereas nocturnal HD was associated with higher risk. In many, but not all, observational studies, short daily HD has been associated with lower risk than both in-center HD and peritoneal dialysis; however, observational studies are subject to unmeasured confounding. Intensive HD can accelerate the loss of residual kidney function in new dialysis patients with substantial urine output and can deplete solutes (eg, phosphorus) to the extent that supplementation is necessary. Finally, intensive HD may increase burden on patients and caregivers, possibly leading to technique failure. Some of these problems might be addressed with careful monitoring, so that relevant interventions (eg, antibiotics, retraining, and respite care) can be delivered. Ultimately, intensive HD is not a panacea for end-stage renal disease. Potential benefits and risks of treatment should be jointly considered.  
  Address Wake Forest University Medical Center, Winston-Salem, NC  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0272-6386 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:27772644 Approved no  
  Call Number ref @ user @ Serial 100046  
Permanent link to this record
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