| Records |
| Author |
Gredilla, A.; Fdez-Ortiz de Vallejuelo, S.; Gomez-Nubla, L.; Carrero, J.A.; de Leao, F.B.; Madariaga, J.M.; Silva, L.F.O. |
| Title |
Are children playgrounds safe play areas? Inorganic analysis and lead isotope ratios for contamination assessment in recreational (Brazilian) parks |
Type |
Journal Article |
| Year |
2017 |
Publication |
Environmental Science and Pollution Research International |
Abbreviated Journal  |
Environ Sci Pollut Res Int |
| Volume |
24 |
Issue |
31 |
Pages |
24333-24345 |
| Keywords |
Chemometric analysis; Human health; Icp-Ms; Lead isotopic ratio; Metals; Normalized-and-Weighted Average Concentration; Playgrounds |
| Abstract |
In city playgrounds, there is a potential risk of harming children's health by contamination coming from anthropogenic activities. With the aim to determinate the sources and the risk of hazardous elements, soil samples were collected in 19 selected playgrounds of different urban and rural areas from the Rio Grande do Sul state (Brazil). The concentration of 23 metals and metalloids and lead isotopic ratios were determined by ICP-MS. The methodology proposed here, firstly, classified the parks according to the average metal content by means of the NWACs (Normalized-and-Weighted Average Concentrations) and assess the contamination risk determining the Contamination Factors (CFs). Finally, statistical tools (correlation analysis and principal component analysis) were used to identify the most important contamination sources. The statistical tools used, together with lead isotopic composition analysis of the samples, revealed that coal combustion is the main source of contamination in the area. Vegetation was identified as a barrier for the contamination coming from the city. Nonetheless, some of the soils present a possible toxicological risk for humans. In fact, Cr, Sb, and Pb concentrations were higher than the Residential Intervention Values (VIRs) defined by the Environmental Protection Agency of the State of Sao Paulo, also in Brazil. |
| Address |
Research Group in Environmental Management and Sustainability, Faculty of Environmental Sciences, Universidad De la Costa, Calle 58, No. 55-56, 080002, Barranquilla, Atlantico, Colombia |
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| Language |
English |
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Series Issue |
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Edition |
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| ISSN |
0944-1344 |
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| Notes |
PMID:28889400 |
Approved |
no |
| Call Number |
ref @ user @ |
Serial |
97629 |
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| Author |
Gerceker, G.O.; Yardimci, F.; Aydinok, Y. |
| Title |
Randomized controlled trial of care bundles with chlorhexidine dressing and advanced dressings to prevent catheter-related bloodstream infections in pediatric hematology-oncology patients |
Type |
Randomized Controlled Trial |
| Year |
2017 |
Publication |
European Journal of Oncology Nursing : the Official Journal of European Oncology Nursing Society |
Abbreviated Journal |
Eur J Oncol Nurs |
| Volume |
28 |
Issue |
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Pages |
14-20 |
| Keywords |
Adolescent; Anti-Bacterial Agents/*therapeutic use; Bacteremia/*drug therapy/*prevention & control; *Bandages; Catheter-Related Infections/*drug therapy/*prevention & control; Catheterization, Central Venous/methods; Central Venous Catheters/microbiology; Child; Child, Preschool; Chlorhexidine/*therapeutic use; Female; Humans; Infant; Infant, Newborn; Male; Patient Care Bundles; Prospective Studies; Turkey |
| Abstract |
PURPOSE: To compare the effects of the care bundles including chlorhexidine dressing and advanced dressings on the catheter-related bloodstream infection (CRBSI) rates in pediatric hematology-oncology patients with central venous catheters (CVCs). METHOD: Twenty-seven PHO patients were recruited to participate in a prospective, randomized study in Turkey. The researcher used care bundles with chlorhexidine dressing in the experimental group (n = 14), and care bundles with advanced dressings in the control group (n = 13). RESULTS: According to the study results, 28.6% of the patients in the experimental group had CRBSI, while this rate was 38.5% in the control group patients. The CRBSI rate in the experimental group was 3.9, and the control group had 4.4 per 1000 inpatient catheter days. There was no exit-site infection in the experimental group. However, the control group had 1.7 per 1000 inpatient catheter days. CONCLUSIONS: Even though there was no difference between the two groups in which the researcher implemented care bundles with chlorhexidine dressing and advanced dressings in terms of CRBSI development, there was reduction in the CRBSI rates thanks to the care bundle approach. It is possible to control the CRBSI rates using care bundles in pediatric hematology-oncology patients. |
| Address |
Ege University Hospital, Department of Paediatric Hematology-Oncology, Izmir, Turkey. Electronic address: yesim.aydinok@yahoo.com |
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English |
Summary Language |
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| ISSN |
1462-3889 |
ISBN |
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| Notes |
PMID:28478850 |
Approved |
no |
| Call Number |
ref @ user @ |
Serial |
98851 |
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| Author |
Gerceker, G.O.; Yardimci, F.; Aydinok, Y. |
| Title |
Randomized controlled trial of care bundles with chlorhexidine dressing and advanced dressings to prevent catheter-related bloodstream infections in pediatric hematology-oncology patients |
Type |
Randomized Controlled Trial |
| Year |
2017 |
Publication |
European Journal of Oncology Nursing : the Official Journal of European Oncology Nursing Society |
Abbreviated Journal |
Eur J Oncol Nurs |
| Volume |
28 |
Issue |
|
Pages |
14-20 |
| Keywords |
Adolescent; Anti-Bacterial Agents/*therapeutic use; Bacteremia/*drug therapy/*prevention & control; *Bandages; Catheter-Related Infections/*drug therapy/*prevention & control; Catheterization, Central Venous/methods; Central Venous Catheters/microbiology; Child; Child, Preschool; Chlorhexidine/*therapeutic use; Female; Humans; Infant; Infant, Newborn; Male; Patient Care Bundles; Prospective Studies; Turkey |
| Abstract |
PURPOSE: To compare the effects of the care bundles including chlorhexidine dressing and advanced dressings on the catheter-related bloodstream infection (CRBSI) rates in pediatric hematology-oncology patients with central venous catheters (CVCs). METHOD: Twenty-seven PHO patients were recruited to participate in a prospective, randomized study in Turkey. The researcher used care bundles with chlorhexidine dressing in the experimental group (n = 14), and care bundles with advanced dressings in the control group (n = 13). RESULTS: According to the study results, 28.6% of the patients in the experimental group had CRBSI, while this rate was 38.5% in the control group patients. The CRBSI rate in the experimental group was 3.9, and the control group had 4.4 per 1000 inpatient catheter days. There was no exit-site infection in the experimental group. However, the control group had 1.7 per 1000 inpatient catheter days. CONCLUSIONS: Even though there was no difference between the two groups in which the researcher implemented care bundles with chlorhexidine dressing and advanced dressings in terms of CRBSI development, there was reduction in the CRBSI rates thanks to the care bundle approach. It is possible to control the CRBSI rates using care bundles in pediatric hematology-oncology patients. |
| Address |
Ege University Hospital, Department of Paediatric Hematology-Oncology, Izmir, Turkey. Electronic address: yesim.aydinok@yahoo.com |
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English |
Summary Language |
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1462-3889 |
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| Notes |
PMID:28478850 |
Approved |
no |
| Call Number |
ref @ user @ |
Serial |
99881 |
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| Author |
Batista, K.M.P.; Eulate-Beramendi, S.A. de; Pina, K.Y.A.R. de; Figueira, P.R.; Canal, A.F.; Chasin, J.M.A.; Meilan, A.; Ugalde, R.; Vega, I.F. |
| Title |
Mesenchymal/proangiogenic factor YKL-40 related to glioblastomas and its relationship with the subventricular zone |
Type |
Journal Article |
| Year |
2017 |
Publication |
Folia Neuropathologica |
Abbreviated Journal |
Folia Neuropathol |
| Volume |
55 |
Issue |
1 |
Pages |
14-22 |
| Keywords |
Ykl-40; glioblastoma; glioblastoma stem cells; subventricular zone |
| Abstract |
<i>Glioblastoma is the most common primary brain tumor. Despite multimodality therapy with aggressive microsurgical resection and adjuvant chemotherapy and radiotherapy, the median survival is below 15 months. Glioblastomas are heterogeneous tumors with high resistance to most chemotherapeutic drugs. According to reliable evidence, YKL-40, one of the best investigated chitinase-like protein, may facilitate invasion, migration and angiogenesis, and could be also responsible for temozolomide resistance in glioblastoma, thus conferring a dismal prognosis. Previous studies have demonstrated that glioblastoma stem cells give rise to endothelial cells through an YKL-40 influence. Such factor is closely related to the subventricular zone. This review focuses on the most recent theories involving the possible relationship between topographic gliomagenesis related to the subventricular zone and YKL-40.</i>. |
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English |
Summary Language |
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Abbreviated Series Title |
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Edition |
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1509-572X |
ISBN |
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| Notes |
PMID:28430288 |
Approved |
no |
| Call Number |
ref @ user @ |
Serial |
96592 |
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| Author |
Glaser, T.; Han, I.; Wu, L.; Zeng, X. |
| Title |
Targeted Nanotechnology in Glioblastoma Multiforme |
Type |
Journal Article |
| Year |
2017 |
Publication |
Frontiers in Pharmacology |
Abbreviated Journal |
Front Pharmacol |
| Volume |
8 |
Issue |
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Pages |
166 |
| Keywords |
blood-brain barrier; cancer stem cell; glioma; nanomedicine; nanotechnology; targeted therapy |
| Abstract |
Gliomas, and in particular glioblastoma multiforme, are aggressive brain tumors characterized by a poor prognosis and high rates of recurrence. Current treatment strategies are based on open surgery, chemotherapy (temozolomide) and radiotherapy. However, none of these treatments, alone or in combination, are considered effective in managing this devastating disease, resulting in a median survival time of less than 15 months. The efficiency of chemotherapy is mainly compromised by the blood-brain barrier (BBB) that selectively inhibits drugs from infiltrating into the tumor mass. Cancer stem cells (CSCs), with their unique biology and their resistance to both radio- and chemotherapy, compound tumor aggressiveness and increase the chances of treatment failure. Therefore, more effective targeted therapeutic regimens are urgently required. In this article, some well-recognized biological features and biomarkers of this specific subgroup of tumor cells are profiled and new strategies and technologies in nanomedicine that explicitly target CSCs, after circumventing the BBB, are detailed. Major achievements in the development of nanotherapies, such as organic poly(propylene glycol) and poly(ethylene glycol) or inorganic (iron and gold) nanoparticles that can be conjugated to metal ions, liposomes, dendrimers and polymeric micelles, form the main scope of this summary. Moreover, novel biological strategies focused on manipulating gene expression (small interfering RNA and clustered regularly interspaced short palindromic repeats [CRISPR]/CRISPR associated protein 9 [Cas 9] technologies) for cancer therapy are also analyzed. The aim of this review is to analyze the gap between CSC biology and the development of targeted therapies. A better understanding of CSC properties could result in the development of precise nanotherapies to fulfill unmet clinical needs. |
| Address |
Department of Histology and Embryology, Zhongshan School of Medicine, Sun Yat-sen UniversityGuangzhou, China |
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English |
Summary Language |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
1663-9812 |
ISBN |
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| Notes |
PMID:28408882 |
Approved |
no |
| Call Number |
ref @ user @ |
Serial |
96596 |
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