| Records |
| Author |
Heydari, N.; Larsen, D.A.; Neira, M.; Beltran Ayala, E.; Fernandez, P.; Adrian, J.; Rochford, R.; Stewart-Ibarra, A.M. |
| Title |
Household Dengue Prevention Interventions, Expenditures, and Barriers to Aedes aegypti Control in Machala, Ecuador |
Type |
Journal Article |
| Year |
2017 |
Publication |
International Journal of Environmental Research and Public Health |
Abbreviated Journal  |
Int J Environ Res Public Health |
| Volume |
14 |
Issue |
2 |
Pages |
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| Keywords |
Aedes/*growth & development; Animals; Dengue/epidemiology/*prevention & control; Ecuador/epidemiology; Housing; Humans; Insect Vectors/*virology; Insecticides/*economics; Mosquito Control/*economics/*methods; Mosquito Nets/*economics; Socioeconomic Factors; Aedes aegypti; Ecuador; Kap; dengue fever; economic cost; mosquito control |
| Abstract |
The Aedes aegypti mosquito is an efficient vector for the transmission of Zika, chikungunya, and dengue viruses, causing major epidemics and a significant social and economic burden throughout the tropics and subtropics. The primary means of preventing these diseases is household-level mosquito control. However, relatively little is known about the economic burden of Ae. aegypti control in resource-limited communities. We surveyed residents from 40 households in a high-risk community at the urban periphery in the city of Machala, Ecuador, on dengue perceptions, vector control interventions, household expenditures, and factors influencing purchasing decisions. The results of this study show that households spend a monthly median of US$2.00, or 1.90% (range: 0.00%, 9.21%) of their family income on Ae. aegypti control interventions. Households reported employing, on average, five different mosquito control and dengue prevention interventions, including aerosols, liquid sprays, repellents, mosquito coils, and unimpregnated bed nets. We found that effectiveness and cost were the most important factors that influence people's decisions to purchase a mosquito control product. Our findings will inform the development and deployment of new Ae. aegypti control interventions by the public health and private sectors, and add to prior studies that have focused on the economic burden of dengue-like illness. |
| Address |
Center for Global Health and Translational Science, State University of New York Upstate Medical University, Syracuse, NY 13210, USA. amstew01@gmail.com |
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English |
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1660-4601 |
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| Notes |
PMID:28212349 |
Approved |
no |
| Call Number |
ref @ user @ |
Serial |
97645 |
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| Author |
Florindo, A.A.; Barrozo, L.V.; Cabral-Miranda, W.; Rodrigues, E.Q.; Turrell, G.; Goldbaum, M.; Cesar, C.L.G.; Giles-Corti, B. |
| Title |
Public Open Spaces and Leisure-Time Walking in Brazilian Adults |
Type |
Journal Article |
| Year |
2017 |
Publication |
International Journal of Environmental Research and Public Health |
Abbreviated Journal |
Int J Environ Res Public Health |
| Volume |
14 |
Issue |
6 |
Pages |
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| Keywords |
Adolescent; Adult; Bicycling; Brazil; Child; Cities; City Planning; Cluster Analysis; Demography; Environment Design; Family Characteristics; Female; Geographic Information Systems; Health Surveys; Humans; Logistic Models; Male; Middle Aged; Parks, Recreational; Residence Characteristics/*statistics & numerical data; Surveys and Questionnaires; Walking/*statistics & numerical data; Young Adult; Brazil; adults; built environment; leisure-time walking; public open spaces |
| Abstract |
Access to public open space is important to increase leisure-time walking (LTW) in high-income countries, but there is little evidence in middle-income countries. We conducted a cross-sectional analysis to examine the relationship between LTW and the presence of different public open spaces (parks, bike paths, and squares) and the mix of these recreational destinations near the homes of adults participating in the Sao Paulo Health Survey (n = 3145). LTW was evaluated by a questionnaire. We delineated buffers (500, 1000, and 1500 m) from the geographic coordinates of the adults' residential addresses using a geographic information system. We used multilevel logistic regression taking account of clustering by census tracts and households, and with adjustment for social, demographics, and health characteristics. The main results showed that the presence of at least two recreational destinations within a 500-m buffer of participants' homes were associated with an increased odds of LTW compared with no destinations present (OR = 1.65; 95% CI 1.09-2.55). No associations were found for destinations further away. These results support actions outlined in the new urban plan for Sao Paulo city and could be used to highlight the importance access to a mix of public open spaces to promote physical activity in megacities of middle-income countries. |
| Address |
Adjunct, School of Population and Global Health, University of Melbourne, Melbourne 3010, Australia. billie.giles-corti@rmit.edu.au |
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1660-4601 |
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PMID:28545242 |
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no |
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ref @ user @ |
Serial |
98023 |
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| Author |
Magrath, J.W.; Kim, Y. |
| Title |
Salinomycin's potential to eliminate glioblastoma stem cells and treat glioblastoma multiforme (Review) |
Type |
Journal Article |
| Year |
2017 |
Publication |
International Journal of Oncology |
Abbreviated Journal |
Int J Oncol |
| Volume |
51 |
Issue |
3 |
Pages |
753-759 |
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| Abstract |
Glioblastoma multiforme (GBM) is the most common and deadliest form of primary brain tumor. Despite treatment with surgery, radiotherapy, and chemotherapy with the drug temozolomide, the expected survival after diagnosis remains low. The median survival is only 14.6 months and the two-year survival is a mere 30%. One reason for this is the heterogeneity of GBM including the presence of glioblastoma cancer stem cells (GSCs). GSCs are a subset of cells with the unique ability to proliferate, differentiate, and create tumors. GSCs are resistant to chemotherapy and radiation and thought to play an important role in recurrence. In order to effectively treat GBM, a drug must be identified that can kill GSCs. The ionophore salinomycin has been shown to kill cancer stem cells and is therefore a promising future treatment for GBM. This study focuses on salinomycin's potential to treat GBM including its ability to reduce the CSC population, its toxicity to normal brain cells, its mechanism of action, and its potential for combination treatment. |
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Department of Chemical and Biological Engineering, The University of Alabama, Tuscaloosa, AL 35487-0203, USA |
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English |
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1019-6439 |
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| Notes |
PMID:28766685 |
Approved |
no |
| Call Number |
ref @ user @ |
Serial |
96573 |
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| Author |
Miranda, A.; Blanco-Prieto, M.; Sousa, J.; Pais, A.; Vitorino, C. |
| Title |
Breaching barriers in glioblastoma. Part I: Molecular pathways and novel treatment approaches |
Type |
Journal Article |
| Year |
2017 |
Publication |
International Journal of Pharmaceutics |
Abbreviated Journal |
Int J Pharm |
| Volume |
531 |
Issue |
1 |
Pages |
372-388 |
| Keywords |
Glioblastoma; Molecular mechanisms; Temozolomide; Therapeutic advances; Therapeutic resistance |
| Abstract |
Glioblastoma multiforme (GBM) is the most common primary brain tumour, and the most aggressive in nature. The prognosis for patients with GBM remains poor, with a median survival time of only 1-2 years. The treatment failure relies on the development of resistance by tumour cells and the difficulty of ensuring that drugs effectively cross the dual blood brain barrier/blood brain tumour barrier. The advanced molecular and genetic knowledge has allowed to identify the mechanisms responsible for temozolomide resistance, which represents the standard of care in GBM, along with surgical resection and radiotherapy. Such resistance has motivated the researchers to investigate new avenues for GBM treatment intended to improve patient survival. In this review, we provide an overview of major obstacles to effective treatment of GBM, encompassing biological barriers, cancer stem cells, DNA repair mechanisms, deregulated signalling pathways and autophagy. New insights and potential therapy approaches for GBM are also discussed, emphasizing localized chemotherapy delivered directly to the brain, immunotherapy, gene therapy and nanoparticle-mediated brain drug delivery. |
| Address |
Faculty of Pharmacy, University of Coimbra, Portugal; Pharmacometrics Group of the Centre for Neurosciences and Cell Biology (CNC), University of Coimbra, Portugal. Electronic address: csvitorino@ff.uc.pt |
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0378-5173 |
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| Notes |
PMID:28755993 |
Approved |
no |
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ref @ user @ |
Serial |
96574 |
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| Author |
Goncalves, P.B.; Hallal, P.C.; Hino, A.A.F.; Reis, R.S. |
| Title |
Individual and environmental correlates of objectively measured physical activity and sedentary time in adults from Curitiba, Brazil |
Type |
Journal Article |
| Year |
2017 |
Publication |
International Journal of Public Health |
Abbreviated Journal |
Int J Public Health |
| Volume |
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Issue |
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Pages |
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Accelerometry; Adults; Environmental correlates; Individual correlates; Physical activity; Sedentary time |
| Abstract |
OBJECTIVES: This study assessed the association of individual and neighborhood environment characteristics and objectively measured physical activity (PA) and sedentary time (ST) in adults from Curitiba, Brazil. METHODS: A population-based cross-sectional study was conducted through face-to-face household interviews in 2010. The analytic sample included 305 adults aged 20-65 years recruited from 32 census tracts selected according to neighborhood walkability and socioeconomic status. Individual and environmental PA correlates were evaluated through standardized and valid self-reported measures, including the Neighborhood Environment Walkability Scale. Minutes per week of PA and ST were assessed through accelerometry. Multi-level regression models were used in the analyses. RESULTS: After adjusting for confounders the strongest individual and environmental correlates associated with ST was residential density (B = 0.14; p = 0.008), light-intensity PA was being a father/mother (B = 35.71; p = 0.025) and moderate-to-vigorous PA was sex (B = 0.91; p < 0.001) and number of cars (one car, B = -1.05; two cars, B = -1.14; p < 0.001). CONCLUSIONS: The associations found with individual and environmental correlates varied accordingly across all outcomes. Future changes in policies and infrastructure should consider the social context of the community and improvements to promote a safer environment in the neighborhood. |
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Prevention Research Center, Brown School, Washington University in St. Louis, St. Louis, MO, USA |
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English |
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1661-8556 |
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| Notes |
PMID:28717827 |
Approved |
no |
| Call Number |
ref @ user @ |
Serial |
97632 |
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