| Records |
| Author |
Jara-Samaniego, J.; Perez-Murcia, M.D.; Bustamante, M.A.; Paredes, C.; Perez-Espinosa, A.; Gavilanes-Teran, I.; Lopez, M.; Marhuenda-Egea, F.C.; Brito, H.; Moral, R. |
| Title |
Development of organic fertilizers from food market waste and urban gardening by composting in Ecuador |
Type |
Journal Article |
| Year |
2017 |
Publication |
PloS one |
Abbreviated Journal |
PLoS One |
| Volume |
12 |
Issue |
7 |
Pages |
e0181621 |
| Keywords |
Analysis of Variance; Carbon/analysis; *Cities; Ecuador; Feasibility Studies; *Fertilizers/analysis/economics; *Food; *Gardening/economics/methods; Nitrogen/analysis; Plants; Recycling/economics/methods; *Soil/chemistry; Temperature; Waste Management/economics/*methods |
Abstract  |
Currently, the management of urban waste streams in developing countries is not optimized yet, and in many cases these wastes are disposed untreated in open dumps. This fact causes serious environmental and health problems due to the presence of contaminants and pathogens. Frequently, the use of specific low-cost strategies reduces the total amount of wastes. These strategies are mainly associated to the identification, separate collection and composting of specific organic waste streams, such as vegetable and fruit refuses from food markets and urban gardening activities. Concretely, in the Chimborazo Region (Ecuador), more than 80% of municipal solid waste is dumped into environment due to the lack of an efficient waste management strategy. Therefore, the aim of this study was to develop a demonstration project at field scale in this region to evaluate the feasibility of implanting the composting technology not only for the management of the organic waste fluxes from food market and gardening activities to be scaled-up in other developing regions, but also to obtain an end-product with a commercial value as organic fertilizer. Three co-composting mixtures were prepared using market wastes mixed with pruning of trees and ornamental palms as bulking agents. Two piles were created using different proportions of market waste and prunings of trees and ornamental palms: pile 1 (50:33:17) with a C/N ratio 25; pile 2: (60:30:10) with C/N ratio 24 and pile 3 (75:0:25) with C/N ratio 33), prepared with market waste and prunings of ornamental palm. Throughout the process, the temperature of the mixtures was monitored and organic matter evolution was determined using thermogravimetric and chemical techniques. Additionally, physico-chemical, chemical and agronomic parameters were determined to evaluate compost quality. The results obtained indicated that all the piles showed a suitable development of the composting process, with a significant organic matter decomposition, reached in a shorter period of time in pile 3. At the end of the process, all the composts showed absence of phytotoxicity and suitable agronomic properties for their use as organic fertilizers. This reflects the viability of the proposed alternative to be scaled-up in developing areas, not only to manage and recycle urban waste fluxes, but also to obtain organic fertilizers, including added value in economic terms related to nutrient contents. |
| Address |
Dept. of Agrochemistry and Environment, Miguel Hernandez University, Orihuela, Alicante, Spain |
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Place of Publication |
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| Language |
English |
Summary Language |
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Edition |
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| ISSN |
1932-6203 |
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Conference |
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| Notes |
PMID:28727757 |
Approved |
no |
| Call Number |
ref @ user @ |
Serial |
98013 |
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| Author |
Brodie, S.; Lee, H.K.; Jiang, W.; Cazacu, S.; Xiang, C.; Poisson, L.M.; Datta, I.; Kalkanis, S.; Ginsberg, D.; Brodie, C. |
| Title |
The novel long non-coding RNA TALNEC2, regulates tumor cell growth and the stemness and radiation response of glioma stem cells |
Type |
Journal Article |
| Year |
2017 |
Publication |
Oncotarget |
Abbreviated Journal |
Oncotarget |
| Volume |
8 |
Issue |
19 |
Pages |
31785-31801 |
| Keywords |
Talnec2; glioblastoma; glioma stem cells; long non-cording RNAs; mesenchymal transformation |
| Abstract |
Despite advances in novel therapeutic approaches for the treatment of glioblastoma (GBM), the median survival of 12-14 months has not changed significantly. Therefore, there is an imperative need to identify molecular mechanisms that play a role in patient survival. Here, we analyzed the expression and functions of a novel lncRNA, TALNEC2 that was identified using RNA seq of E2F1-regulated lncRNAs. TALNEC2 was localized to the cytosol and its expression was E2F1-regulated and cell-cycle dependent. TALNEC2 was highly expressed in GBM with poor prognosis, in GBM specimens derived from short-term survivors and in glioma cells and glioma stem cells (GSCs). Silencing of TALNEC2 inhibited cell proliferation and arrested the cells in the G1\S phase of the cell cycle in various cancer cell lines. In addition, silencing of TALNEC2 decreased the self-renewal and mesenchymal transformation of GSCs, increased sensitivity of these cells to radiation and prolonged survival of mice bearing GSC-derived xenografts. Using miRNA array analysis, we identified specific miRNAs that were altered in the silenced cells that were associated with cell-cycle progression, proliferation and mesenchymal transformation. Two of the downregulated miRNAs, miR-21 and miR-191, mediated some of TALNEC2 effects on the stemness and mesenchymal transformation of GSCs. In conclusion, we identified a novel E2F1-regulated lncRNA that is highly expressed in GBM and in tumors from patients of short-term survival. The expression of TALNEC2 is associated with the increased tumorigenic potential of GSCs and their resistance to radiation. We conclude that TALNEC2 is an attractive therapeutic target for the treatment of GBM. |
| Address |
Davidson Laboratory of Cell Signaling and Tumorigenesis, Hermelin Brain Tumor Center, Department of Neurosurgery, Detroit, MI, USA |
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English |
Summary Language |
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Edition |
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| ISSN |
1949-2553 |
ISBN |
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Conference |
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| Notes |
PMID:28423669 |
Approved |
no |
| Call Number |
ref @ user @ |
Serial |
96594 |
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| Author |
Emery, I.F.; Gopalan, A.; Wood, S.; Chow, K.-H.; Battelli, C.; George, J.; Blaszyk, H.; Florman, J.; Yun, K. |
| Title |
Expression and function of ABCG2 and XIAP in glioblastomas |
Type |
Journal Article |
| Year |
2017 |
Publication |
Journal of Neuro-Oncology |
Abbreviated Journal |
J Neurooncol |
| Volume |
133 |
Issue |
1 |
Pages |
47-57 |
| Keywords |
Abcg2; Glioblastoma; Glioma stem cells; Ko143; Xiap |
| Abstract |
Despite multimodal treatment that includes surgery, radiation and chemotherapy, virtually all glioblastomas (GBM) recur, indicating that these interventions are insufficient to eradicate all malignant cells. To identify potential new therapeutic targets in GBMs, we examined the expression and function of proteins that are associated with therapy resistance and cancer cell survival. We measured the expression of eight such proteins in 50 GBM samples by immunohistochemistry and analyzed patient survival. We report that GBM patients with high expression of ABCG2 (also called BCRP) or XIAP at the protein level had worse survival than those with low expression. The adjusted hazard ratio for ABCG2 was 2.35 and for XIAP was 2.65. Since glioma stem cells (GSCs) have been shown to be more resistant than bulk tumor cells to anti-cancer therapies and to express high levels of these proteins, we also sought to determine if ABCG2 and XIAP have functional roles in GSCs. We used small molecule inhibitors to treat patient-derived GBM tumorspheres in vitro and observed that inhibitors of ABCG2, Ko143 and fumitremorgin, significantly reduced self-renewal. These results suggest that ABCG2 and XIAP proteins may be useful indicators of patient survival and that inhibition of ABCG2 may be a promising therapeutic strategy in GBMs. |
| Address |
Peak Center for Brain and Pituitary Tumors, Houston Methodist Research Institute, 6670 Bertner Ave, Houston, TX, 77030, USA. kyun@houstonmethodist.org |
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English |
Summary Language |
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Original Title |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
0167-594X |
ISBN |
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Expedition |
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Conference |
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| Notes |
PMID:28432589 |
Approved |
no |
| Call Number |
ref @ user @ |
Serial |
96591 |
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| Author |
Blot, S.; Bauer, G.; Fraser, M.; Nleya, M.; Wadham, M. |
| Title |
AIDS Service Organization Access Among African, Caribbean and Other Black Residents of an Average Canadian City |
Type |
Journal Article |
| Year |
2017 |
Publication |
Journal of Immigrant and Minority Health |
Abbreviated Journal |
J Immigr Minor Health |
| Volume |
19 |
Issue |
4 |
Pages |
851-860 |
| Keywords |
African; Black people; Caribbean; Hiv/Aids; Health disparities; Health services research; Immigrant health; Minority health |
| Abstract |
Due to heightened vulnerability to HIV/AIDS, African, Caribbean and Black (ACB) communities are priority groups for prevention and intervention services in Canada. However, it is not clear which factors may affect ACB communities' access to these services. We evaluated access to the local AIDS service organization (ASO) in Middlesex-London by using data from the Black, African and Caribbean Canadian Health Study. Modified Poisson regression was used to obtain prevalence risk ratios for factors associated with three measures of access: familiarity with the ASO, willingness to access, and realized access. In adjusted analyses, older ACB community members were more likely to be familiar with the ASO, willing to access it, and have actually gone there. Canadian-born participants were less likely to have been to the ASO than recent immigrants. These results have implications for reaching specific segments of ACB communities for HIV/AIDS-related services in Canada. |
| Address |
Women and HIV/AIDS Initiative, Toronto, ON, Canada |
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| Language |
English |
Summary Language |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
1557-1912 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
PMID:26895153 |
Approved |
no |
| Call Number |
ref @ user @ |
Serial |
97194 |
| Permanent link to this record |
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| Author |
Blot, S.; Bauer, G.; Fraser, M.; Nleya, M.; Wadham, M. |
| Title |
AIDS Service Organization Access Among African, Caribbean and Other Black Residents of an Average Canadian City |
Type |
Journal Article |
| Year |
2017 |
Publication |
Journal of Immigrant and Minority Health |
Abbreviated Journal |
J Immigr Minor Health |
| Volume |
19 |
Issue |
4 |
Pages |
851-860 |
| Keywords |
African; Black people; Caribbean; Hiv/Aids; Health disparities; Health services research; Immigrant health; Minority health |
| Abstract |
Due to heightened vulnerability to HIV/AIDS, African, Caribbean and Black (ACB) communities are priority groups for prevention and intervention services in Canada. However, it is not clear which factors may affect ACB communities' access to these services. We evaluated access to the local AIDS service organization (ASO) in Middlesex-London by using data from the Black, African and Caribbean Canadian Health Study. Modified Poisson regression was used to obtain prevalence risk ratios for factors associated with three measures of access: familiarity with the ASO, willingness to access, and realized access. In adjusted analyses, older ACB community members were more likely to be familiar with the ASO, willing to access it, and have actually gone there. Canadian-born participants were less likely to have been to the ASO than recent immigrants. These results have implications for reaching specific segments of ACB communities for HIV/AIDS-related services in Canada. |
| Address |
Women and HIV/AIDS Initiative, Toronto, ON, Canada |
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Thesis |
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| Language |
English |
Summary Language |
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Original Title |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
1557-1912 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
PMID:26895153 |
Approved |
no |
| Call Number |
ref @ user @ |
Serial |
97682 |
| Permanent link to this record |
