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Author  |
Mistry, A.M.; Dewan, M.C.; White-Dzuro, G.A.; Brinson, P.R.; Weaver, K.D.; Thompson, R.C.; Ihrie, R.A.; Chambless, L.B. |
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Title |
Decreased survival in glioblastomas is specific to contact with the ventricular-subventricular zone, not subgranular zone or corpus callosum |
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Journal Article |
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Year |
2017 |
Publication |
Journal of Neuro-Oncology |
Abbreviated Journal |
J Neurooncol |
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Volume |
132 |
Issue |
2 |
Pages |
341-349 |
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Keywords |
Glioblastoma; Stem cells; Subgranular zone; Subventricular zone; Survival; Ventricular-subventricular zone |
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Abstract |
The clinical effect of radiographic contact of glioblastoma (GBM) with neurogenic zones (NZ)-the ventricular-subventricular (VSVZ) and subgranular (SGZ) zones-and the corpus callosum (CC) remains unclear and, in the case of the SGZ, unexplored. We investigated (1) if GBM contact with a NZ correlates with decreased survival; (2) if so, whether this effect is associated with a specific NZ; and (3) if radiographic contact with or invasion of the CC by GBM is associated with decreased survival. We retrospectively identified 207 adult patients who underwent cytoreductive surgery for GBM followed by chemotherapy and/or radiation. Age, preoperative Karnofsky performance status score (KPS), and extent of resection were recorded. Preoperative MRIs were blindly analyzed to calculate tumor volume and assess its contact with VSVZ, SGZ, CC, and cortex. Overall (OS) and progression free (PFS) survivals were calculated and analyzed with multivariate Cox analyses. Among the 207 patients, 111 had GBM contacting VSVZ (VSVZ+GBMs), 23 had SGZ+GBMs, 52 had CC+GBMs, and 164 had cortex+GBMs. VSVZ+, SGZ+, and CC+ GBMs were significantly larger in size relative to their respective non-contacting controls. Multivariate Cox survival analyses revealed GBM contact with the VSVZ, but not SGZ, CC, or cortex, as an independent predictor of lower OS, PFS, and early recurrence. We hypothesize that the VSVZ niche has unique properties that contribute to GBM pathobiology in adults. |
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Department of Neurological Surgery, Vanderbilt University Medical Center, T-4224 Medical Center North, 1161 21st Avenue South, Nashville, TN, 37232-2380, USA |
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0167-594X |
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PMID:28074322 |
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Call Number |
ref @ user @ |
Serial |
96612 |
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Author |
Moimaz, S.A.S.; Rocha, N.B.; Garbin, C.A.S.; Rovida, T.A.; Saliba, N.A. |
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Title |
Factors affecting intention to breastfeed of a group of Brazilian childbearing women |
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Journal Article |
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Year |
2017 |
Publication |
Women and Birth : Journal of the Australian College of Midwives |
Abbreviated Journal |
Women Birth |
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Volume |
30 |
Issue |
2 |
Pages |
e119-e124 |
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Keywords |
Adult; Age Factors; Brazil; Breast Feeding/*psychology; Female; Humans; Mothers/*psychology; Pregnancy; Retrospective Studies; Socioeconomic Factors; Young Adult; Brazil; Breastfeeding; Breastfeeding difficulties; Breastfeeding initiation; Pregnancy |
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Abstract |
BACKGROUND: Knowing the intention of mothers is important to plan actions to improve exclusive breastfeeding rates. AIM: The objective of this retrospective study was to verify the intention to breastfeed and the intended breastfeeding duration of a group of women participating in a public prenatal dental care program in the city of Aracatuba, Brazil. METHODS: The records of 933 childbearing women were analyzed and their intention to breastfeed and intended breastfeeding duration were associated to women's age, ethnicity, marital status, education, employment, number of gestations, previous breastfeeding experience, previous breastfeeding guidance, presence of complications during pregnancy, and systemic diseases. Data were inserted into Epi Info 2000 and analyzed with Biostat, at a 5% level of significance, and confidence interval of 95%. FINDINGS: Participants mean age was 26.1+/-5.9years. The majority of women (96.5%) declared their intention to breastfeed their babies. The main variables to affect the intention to breastfeed were the number of gestations (p=0.001), previous breastfeeding experience (p=0.03), and previous breastfeeding guidance (p=0.01). Intended breastfeeding duration was significantly affected by women's age (p=0.04), employment (0.02), the number of gestations (p=0.001), and previous breastfeeding experience (p=0.04). CONCLUSIONS: Previous positive breastfeeding experience and guidance during prenatal examinations positively affected women's intention to breastfeed; while older, unemployed women in their second or more gestation and previous breastfeeding experience intended to breastfeed their children for longer periods of time. |
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Preventive and Social Dentistry Department, School of Dentistry, Sao Paulo State University (UNESP), Aracatuba, Brazil. Electronic address: nemre@foa.unesp.br |
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1871-5192 |
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PMID:27840072 |
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Call Number |
ref @ user @ |
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97339 |
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Author |
Momeny, M.; Moghaddaskho, F.; Gortany, N.K.; Yousefi, H.; Sabourinejad, Z.; Zarrinrad, G.; Mirshahvaladi, S.; Eyvani, H.; Barghi, F.; Ahmadinia, L.; Ghazi-Khansari, M.; Dehpour, A.R.; Amanpour, S.; Tavangar, S.M.; Dardaei, L.; Emami, A.H.; Alimoghaddam, K.; Ghavamzadeh, A.; Ghaffari, S.H. |
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Title |
Blockade of vascular endothelial growth factor receptors by tivozanib has potential anti-tumour effects on human glioblastoma cells |
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Journal Article |
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Year |
2017 |
Publication |
Scientific Reports |
Abbreviated Journal |
Sci Rep |
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7 |
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Pages |
44075 |
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Glioblastoma (GBM) remains one of the most fatal human malignancies due to its high angiogenic and infiltrative capacities. Even with optimal therapy including surgery, radiotherapy and temozolomide, it is essentially incurable. GBM is among the most neovascularised neoplasms and its malignant progression associates with striking neovascularisation, evidenced by vasoproliferation and endothelial cell hyperplasia. Targeting the pro-angiogenic pathways is therefore a promising anti-glioma strategy. Here we show that tivozanib, a pan-inhibitor of vascular endothelial growth factor (VEGF) receptors, inhibited proliferation of GBM cells through a G2/M cell cycle arrest via inhibition of polo-like kinase 1 (PLK1) signalling pathway and down-modulation of Aurora kinases A and B, cyclin B1 and CDC25C. Moreover, tivozanib decreased adhesive potential of these cells through reduction of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1). Tivozanib diminished GBM cell invasion through impairing the proteolytic cascade of cathepsin B/urokinase-type plasminogen activator (uPA)/matrix metalloproteinase-2 (MMP-2). Combination of tivozanib with EGFR small molecule inhibitor gefitinib synergistically increased sensitivity to gefitinib. Altogether, these findings suggest that VEGFR blockade by tivozanib has potential anti-glioma effects in vitro. Further in vivo studies are warranted to explore the anti-tumour activity of tivozanib in combinatorial approaches in GBM. |
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Haematology/Oncology and Stem Cell Transplantation Research Centre, Shariati Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran |
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2045-2322 |
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PMID:28287096 |
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Call Number |
ref @ user @ |
Serial |
96601 |
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Author |
Monge-Rojas, R.; Fuster-Baraona, T.; Garita-Arce, C.; Sanchez-Lopez, M.; Colon-Ramos, U.; Smith-Castro, V. |
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Title |
How Self-Objectification Impacts Physical Activity Among Adolescent Girls in Costa Rica |
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Journal Article |
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Year |
2017 |
Publication |
Journal of Physical Activity & Health |
Abbreviated Journal |
J Phys Act Health |
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Volume |
14 |
Issue |
2 |
Pages |
123-129 |
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Keywords |
Adolescent; *Adolescent Behavior; Body Image/*psychology; Costa Rica; Cultural Characteristics; *Exercise; Female; Focus Groups; Humans; Male; Women's Health; Latin America; female identity; machismo; sexual harassment |
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BACKGROUND: In Latin America, more than 80% of adolescent girls are physically inactive. Inactivity may be reinforced by female stereotypes and objectification in the Latin American sociocultural context. METHODS: We examined the influence of objectification on the adoption of an active lifestyle among 192 adolescents (14 and 17 years old) from urban and rural areas in Costa Rica. Analyses of 48 focus-groups sessions were grounded in Objectification Theory. RESULTS: Vigorous exercises were gender-typed as masculine while girls had to maintain an aesthetic appearance at all times. Adolescents described how girls were anxious around the prospect of being shamed and sexually objectified during exercises. This contributed to a decrease in girls' desire to engage in physical activities. Among males, there is also a budding tolerance of female participation in vigorous sports, as long as girls maintained a feminine stereotype outside their participation. CONCLUSION: Self-objectification influenced Costa Rican adolescent girls' decisions to participate in physical activities. Interventions may include: procuring safe environments for physical activity where girls are protected from fear of ridicule and objectification; sensitizing boys about girl objectification and fostering the adoption of a modern positive masculine and female identities to encourage girls' participation in sports. |
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1543-3080 |
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PMID:27775480 |
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Call Number |
ref @ user @ |
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97269 |
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Author |
Monge-Rojas, R.; Fuster-Baraona, T.; Garita-Arce, C.; Sanchez-Lopez, M.; Colon-Ramos, U.; Smith-Castro, V. |
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Title |
How Self-Objectification Impacts Physical Activity Among Adolescent Girls in Costa Rica |
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Journal Article |
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Year |
2017 |
Publication |
Journal of Physical Activity & Health |
Abbreviated Journal |
J Phys Act Health |
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Volume |
14 |
Issue |
2 |
Pages |
123-129 |
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Keywords |
Adolescent; *Adolescent Behavior; Body Image/*psychology; Costa Rica; Cultural Characteristics; *Exercise; Female; Focus Groups; Humans; Male; Women's Health; Latin America; female identity; machismo; sexual harassment |
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Abstract |
BACKGROUND: In Latin America, more than 80% of adolescent girls are physically inactive. Inactivity may be reinforced by female stereotypes and objectification in the Latin American sociocultural context. METHODS: We examined the influence of objectification on the adoption of an active lifestyle among 192 adolescents (14 and 17 years old) from urban and rural areas in Costa Rica. Analyses of 48 focus-groups sessions were grounded in Objectification Theory. RESULTS: Vigorous exercises were gender-typed as masculine while girls had to maintain an aesthetic appearance at all times. Adolescents described how girls were anxious around the prospect of being shamed and sexually objectified during exercises. This contributed to a decrease in girls' desire to engage in physical activities. Among males, there is also a budding tolerance of female participation in vigorous sports, as long as girls maintained a feminine stereotype outside their participation. CONCLUSION: Self-objectification influenced Costa Rican adolescent girls' decisions to participate in physical activities. Interventions may include: procuring safe environments for physical activity where girls are protected from fear of ridicule and objectification; sensitizing boys about girl objectification and fostering the adoption of a modern positive masculine and female identities to encourage girls' participation in sports. |
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1543-3080 |
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PMID:27775480 |
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Call Number |
ref @ user @ |
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98041 |
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