| Records |
| Author |
Zapotoczna, M.; Forde, E.; Hogan, S.; Humphreys, H.; O'Gara, J.P.; Fitzgerald-Hughes, D.; Devocelle, M.; O'Neill, E. |
| Title |
Eradication of Staphylococcus aureus Biofilm Infections Using Synthetic Antimicrobial Peptides |
Type |
Journal Article |
| Year |
2017 |
Publication |
The Journal of Infectious Diseases |
Abbreviated Journal |
J Infect Dis |
| Volume |
215 |
Issue |
6 |
Pages  |
975-983 |
| Keywords |
Animals; Anti-Bacterial Agents/*pharmacology; Biofilms/*drug effects; Catheter-Related Infections/*drug therapy; Cytokines/blood; Disease Models, Animal; Humans; Methicillin-Resistant Staphylococcus aureus/*drug effects; Microbial Sensitivity Tests; Peptides/*pharmacology; Peptides, Cyclic/pharmacology; Rats; Rats, Sprague-Dawley; Staphylococcal Infections/*drug therapy; Vancomycin/administration & dosage; *Staphylococcus aureus; *antimicrobial peptides (AMPs); *biofilm; *catheter lock solution (CLS) |
| Abstract |
Here, we demonstrate that antimicrobial peptides (AMPs) are an effective antibiofilm treatment when applied as catheter lock solutions (CLSs) against S. aureus biofilm infections. The activity of synthetic AMPs (Bac8c, HB43, P18, Omiganan, WMR, Ranalexin, and Polyphemusin) was measured against early and mature biofilms produced by methicillin-resistant S. aureus and methicillin-susceptible S. aureus isolates from patients with device-related infections grown under in vivo-relevant biofilm conditions. The cytotoxic and hemolytic activities of the AMPs against human cells and their immunomodulatory potential in human blood were also characterized. The D-Bac8c2,5Leu variant emerged as the most effective AMP during in vitro studies and was also highly effective in eradicating S. aureus biofilm infection when used in a CLS rat central venous catheter infection model. These data support the potential use of D-Bac8c2,5Leu, alone or in combination with other AMPs, in the treatment of S. aureus intravenous catheter infections. |
| Address |
Department of Microbiology, School of Natural Sciences, National University of Ireland, Galway, Ireland |
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English |
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| ISSN |
0022-1899 |
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| Notes |
PMID:28453851 |
Approved |
no |
| Call Number |
ref @ user @ |
Serial |
100541 |
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| Author |
Del Campo Vega, C.; Tutte, V.; Bermudez, G.; Parra, D.C. |
| Title |
Impact on Area-Level Physical Activity Following the Implementation of a Fitness Zone in Montevideo, Uruguay |
Type |
Journal Article |
| Year |
2017 |
Publication |
Journal of Physical Activity & Health |
Abbreviated Journal |
J Phys Act Health |
| Volume |
14 |
Issue |
11 |
Pages |
883-887 |
| Keywords |
Soparc; observation; parks |
| Abstract |
BACKGROUND: The aim of the study was to measure the level of physical activity (PA) of the users of an urban park before and after the installation of 2 fitness zones (FZs) and to assess the impact of that intervention on the users' level of PA. METHODS: The System for Observing Play and Recreation in Communities method was applied in the urban plaza Liber Seregni in Montevideo (Uruguay): 14 different areas were mapped and then recategorized as fitness (for PAs, including sports), green, and paved zones. Observations were made in the spring (Sep-Oct) of 2011 and 2014, before and after placing 2 FZs. Participation was analyzed by gender, year, mapped areas, and zones, and significant differences were assessed using the chi2 test. RESULTS: In total, 7342 individuals (4091 men and 3251 women) were observed. A greater number of people with intense PA could be seen in the FZ, with significant differences between 2011 (45%) and 2014 (70%; P < .05). CONCLUSION: This is the first longitudinal study on the impact of an intervention to increase the level of PA in public spaces in Uruguay. Higher intensity levels of PA and fewer sedentary people were observed after the installation of the FZ. |
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English |
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| ISSN |
1543-3080 |
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| Notes |
PMID:28556669 |
Approved |
no |
| Call Number |
ref @ user @ |
Serial |
98022 |
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| Author |
Blot, S.; Bauer, G.; Fraser, M.; Nleya, M.; Wadham, M. |
| Title |
AIDS Service Organization Access Among African, Caribbean and Other Black Residents of an Average Canadian City |
Type |
Journal Article |
| Year |
2017 |
Publication |
Journal of Immigrant and Minority Health |
Abbreviated Journal |
J Immigr Minor Health |
| Volume |
19 |
Issue |
4 |
Pages |
851-860 |
| Keywords |
African; Black people; Caribbean; Hiv/Aids; Health disparities; Health services research; Immigrant health; Minority health |
| Abstract |
Due to heightened vulnerability to HIV/AIDS, African, Caribbean and Black (ACB) communities are priority groups for prevention and intervention services in Canada. However, it is not clear which factors may affect ACB communities' access to these services. We evaluated access to the local AIDS service organization (ASO) in Middlesex-London by using data from the Black, African and Caribbean Canadian Health Study. Modified Poisson regression was used to obtain prevalence risk ratios for factors associated with three measures of access: familiarity with the ASO, willingness to access, and realized access. In adjusted analyses, older ACB community members were more likely to be familiar with the ASO, willing to access it, and have actually gone there. Canadian-born participants were less likely to have been to the ASO than recent immigrants. These results have implications for reaching specific segments of ACB communities for HIV/AIDS-related services in Canada. |
| Address |
Women and HIV/AIDS Initiative, Toronto, ON, Canada |
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English |
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| ISSN |
1557-1912 |
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| Notes |
PMID:26895153 |
Approved |
no |
| Call Number |
ref @ user @ |
Serial |
97194 |
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| Author |
Blot, S.; Bauer, G.; Fraser, M.; Nleya, M.; Wadham, M. |
| Title |
AIDS Service Organization Access Among African, Caribbean and Other Black Residents of an Average Canadian City |
Type |
Journal Article |
| Year |
2017 |
Publication |
Journal of Immigrant and Minority Health |
Abbreviated Journal |
J Immigr Minor Health |
| Volume |
19 |
Issue |
4 |
Pages |
851-860 |
| Keywords |
African; Black people; Caribbean; Hiv/Aids; Health disparities; Health services research; Immigrant health; Minority health |
| Abstract |
Due to heightened vulnerability to HIV/AIDS, African, Caribbean and Black (ACB) communities are priority groups for prevention and intervention services in Canada. However, it is not clear which factors may affect ACB communities' access to these services. We evaluated access to the local AIDS service organization (ASO) in Middlesex-London by using data from the Black, African and Caribbean Canadian Health Study. Modified Poisson regression was used to obtain prevalence risk ratios for factors associated with three measures of access: familiarity with the ASO, willingness to access, and realized access. In adjusted analyses, older ACB community members were more likely to be familiar with the ASO, willing to access it, and have actually gone there. Canadian-born participants were less likely to have been to the ASO than recent immigrants. These results have implications for reaching specific segments of ACB communities for HIV/AIDS-related services in Canada. |
| Address |
Women and HIV/AIDS Initiative, Toronto, ON, Canada |
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English |
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1557-1912 |
ISBN |
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| Notes |
PMID:26895153 |
Approved |
no |
| Call Number |
ref @ user @ |
Serial |
97682 |
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| Author |
Magrath, J.W.; Kim, Y. |
| Title |
Salinomycin's potential to eliminate glioblastoma stem cells and treat glioblastoma multiforme (Review) |
Type |
Journal Article |
| Year |
2017 |
Publication |
International Journal of Oncology |
Abbreviated Journal |
Int J Oncol |
| Volume |
51 |
Issue |
3 |
Pages |
753-759 |
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| Abstract |
Glioblastoma multiforme (GBM) is the most common and deadliest form of primary brain tumor. Despite treatment with surgery, radiotherapy, and chemotherapy with the drug temozolomide, the expected survival after diagnosis remains low. The median survival is only 14.6 months and the two-year survival is a mere 30%. One reason for this is the heterogeneity of GBM including the presence of glioblastoma cancer stem cells (GSCs). GSCs are a subset of cells with the unique ability to proliferate, differentiate, and create tumors. GSCs are resistant to chemotherapy and radiation and thought to play an important role in recurrence. In order to effectively treat GBM, a drug must be identified that can kill GSCs. The ionophore salinomycin has been shown to kill cancer stem cells and is therefore a promising future treatment for GBM. This study focuses on salinomycin's potential to treat GBM including its ability to reduce the CSC population, its toxicity to normal brain cells, its mechanism of action, and its potential for combination treatment. |
| Address |
Department of Chemical and Biological Engineering, The University of Alabama, Tuscaloosa, AL 35487-0203, USA |
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English |
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1019-6439 |
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| Notes |
PMID:28766685 |
Approved |
no |
| Call Number |
ref @ user @ |
Serial |
96573 |
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