| Records |
| Author |
Roldos, M.I.; Hopenhayn, C.; Sacoto, F.; Bustamante, K. |
| Title |
Developing local health policy: Profiling needs and opportunities in the Municipality of Quito, Ecuador |
Type |
Journal Article |
| Year |
2017 |
Publication |
Journal of Public Health Policy |
Abbreviated Journal |
J Public Health Policy |
| Volume |
|
Issue |
|
Pages |
|
| Keywords |
Quito; local health policy; municipality; policy development; public health |
| Abstract |
We describe the steps taken and analysis applied in developing a local health policy agenda for the city of Quito, in Ecuador. In 2014, the Health Commissioner's Office of the Municipality of Quito analyzed the city's epidemiological health profiles, social determinants of health, the legal authority of the Municipality, and relevant literature to understand the city's health burden and develop a Ten-Year Health Plan (2015-2025). Results revealed that Quito's population suffered from noncommunicable chronic diseases (diabetes and hypertension) and identified the primary risk factors (poor nutrition, physical inactivity, and resulting overweight or obesity). Other common conditions included respiratory diseases, mental health conditions, deaths and injuries from motor vehicles, violence, and physical insecurity. The plan emphasized health promotion and disease prevention with the aim of transforming citizens' health perceptions with their active participation by fostering public and private intersectoral commitment to improve the quality of life of the population . |
| Address |
Epidemiology Surveillance, Health Commissioner's Office, Municipality of Quito, Ecuador |
| Corporate Author |
|
Thesis |
|
| Publisher |
|
Place of Publication |
|
Editor |
|
| Language |
English |
Summary Language |
|
Original Title |
|
| Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
| Series Volume |
|
Series Issue |
|
Edition |
|
ISSN  |
0197-5897 |
ISBN |
|
Medium |
|
| Area |
|
Expedition |
|
Conference |
|
| Notes |
PMID:28242874 |
Approved |
no |
| Call Number |
ref @ user @ |
Serial |
97335 |
| Permanent link to this record |
| |
|
| |
| Author |
Jin, W.-L.; Mao, X.-Y.; Qiu, G.-Z. |
| Title |
Targeting Deubiquitinating Enzymes in Glioblastoma Multiforme: Expectations and Challenges |
Type |
Journal Article |
| Year |
2017 |
Publication |
Medicinal Research Reviews |
Abbreviated Journal |
Med Res Rev |
| Volume |
37 |
Issue |
3 |
Pages |
627-661 |
| Keywords |
Animals; Carcinogenesis/pathology; Deubiquitinating Enzymes/antagonists & inhibitors/*metabolism; Enzyme Inhibitors/pharmacology; Glioblastoma/*enzymology/*therapy; Humans; *Molecular Targeted Therapy; Neoplastic Stem Cells/drug effects/pathology; DUB inhibitor; DUBs; glioblastoma; glioma stem cells; proteasome |
| Abstract |
Glioblastoma (GBM) is regarded as the most common primary intracranial neoplasm. Despite standard treatment with tumor resection and radiochemotherapy, the outcome remains gloomy. It is evident that a combination of oncogenic gain of function and tumor-suppressive loss of function has been attributed to glioma initiation and progression. The ubiquitin-proteasome system is a well-orchestrated system that controls the fate of most proteins by striking a dynamic balance between ubiquitination and deubiquitination of substrates, having a profound influence on the modulation of oncoproteins, tumor suppressors, and cellular signaling pathways. In recent years, deubiquitinating enzymes (DUBs) have emerged as potential anti-cancer targets due to their targeting several key proteins involved in the regulation of tumorigenesis, apoptosis, senescence, and autophagy. This review attempts to summarize recent studies of GBM-associated DUBs, their roles in various cellular processes, and discuss the relation between DUBs deregulation and gliomagenesis, especially how DUBs regulate glioma stem cells pluripotency, microenvironment, and resistance of radiation and chemotherapy through core stem-cell transcriptional factors. We also review recent achievements and progress in the development of potent and selective reversible inhibitors of DUBs, and attempted to find a potential GBM treatment by DUBs intervention. |
| Address |
Department of Neurosurgery, General Hospital of Jinan Military Command, Jinan, 250031, P. R. China |
| Corporate Author |
|
Thesis |
|
| Publisher |
|
Place of Publication |
|
Editor |
|
| Language |
English |
Summary Language |
|
Original Title |
|
| Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
| Series Volume |
|
Series Issue |
|
Edition |
|
| ISSN |
0198-6325 |
ISBN |
|
Medium |
|
| Area |
|
Expedition |
|
Conference |
|
| Notes |
PMID:27775833 |
Approved |
no |
| Call Number |
ref @ user @ |
Serial |
96629 |
| Permanent link to this record |
| |
|
| |
| Author |
Fernandez Palacios, L.; Barrientos Augustinus, E.; Raudales Urquia, C.; Frontela Saseta, C.; Ros Berruezo, G. |
| Title |
Degree of malnutrition and its relationship with major structural and eating factors in Honduran preschool population. Prevalence of breastfeeding |
Type |
Journal Article |
| Year |
2017 |
Publication |
Nutricion Hospitalaria |
Abbreviated Journal |
Nutr Hosp |
| Volume |
34 |
Issue |
3 |
Pages |
639-646 |
| Keywords |
*Honduras; *Child malnutrition; *Breastfeeding |
| Abstract |
Introduction: Child malnutrition remains a serious public health problem in Honduras, with a national prevalence according to the World Health Organization (WHO) reference values of 29% in children under fi ve. In addition, the average chronic malnutrition in the region amounts to 80% in poor and indigenous communities, making Honduras the second country in Central America with the highest incidence of chronic malnutrition. Another problem of the region is the early cessation of exclusive breastfeeding: only 29.7% of children were exclusively breastfed until they were six months. Therefore, the study seeks to understand, identify and quantify the situation determinants and provide information for the design of public policies. Material and method:: The study consisted of a cross-sectional descriptive anthropometric assessment in which the nutritional status and the prevalence of undernourishment, malnutrition and malnutrition in 141 children aged between six months and fi ve years, belonging to urban and rural regions of the country, were analyzed, as well as assessing the prevalence of breastfeeding in fi ve Honduran departments (Intibuca, Lempira, Atlantida, Olancho and Francisco Morazan). Results and conclusion: When making the analysis by departments, differences regarding nutritional status and breastfeeding were observed between urban and rural areas, the latter being doubled in the case of chronic malnutrition and underweight, with percentages of 14.6% in urban areas versus28.8% in rural areas, and 4.6% in urban areas compared to 9% in rural areas, respectively. However, with respect to acute malnutrition and overweight in both regions, similar values were observed, above 1.1% for acute and 14% for overweight malnutrition. In relation to exclusive breastfeeding for six months, the departments of Olancho and Lempira maintained it for two years, with a percentage distribution of 80% and 48%, respectively. It must be noted that 36% of mothers did not provide breastfeeding, with the highest rate (15%) in the department of Francisco Morazan. |
| Address |
. l.fernandezpalacios@um.es |
| Corporate Author |
|
Thesis |
|
| Publisher |
|
Place of Publication |
|
Editor |
|
| Language |
Spanish |
Summary Language |
|
Original Title |
Grado de malnutricion y su relacion con los principales factores estructurales y alimentarios de la poblacion preescolar hondurena. Prevalencia de la lactancia materna en los mismos |
| Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
| Series Volume |
|
Series Issue |
|
Edition |
|
| ISSN |
0212-1611 |
ISBN |
|
Medium |
|
| Area |
|
Expedition |
|
Conference |
|
| Notes |
PMID:28627201 |
Approved |
no |
| Call Number |
ref @ user @ |
Serial |
97043 |
| Permanent link to this record |
| |
|
| |
| Author |
Fernandez Palacios, L.; Barrientos Augustinus, E.; Raudales Urquia, C.; Frontela Saseta, C.; Ros Berruezo, G. |
| Title |
Degree of malnutrition and its relationship with major structural and eating factors in Honduran preschool population. Prevalence of breastfeeding |
Type |
Journal Article |
| Year |
2017 |
Publication |
Nutricion Hospitalaria |
Abbreviated Journal |
Nutr Hosp |
| Volume |
34 |
Issue |
3 |
Pages |
639-646 |
| Keywords |
*Honduras; *Child malnutrition; *Breastfeeding |
| Abstract |
Introduction: Child malnutrition remains a serious public health problem in Honduras, with a national prevalence according to the World Health Organization (WHO) reference values of 29% in children under fi ve. In addition, the average chronic malnutrition in the region amounts to 80% in poor and indigenous communities, making Honduras the second country in Central America with the highest incidence of chronic malnutrition. Another problem of the region is the early cessation of exclusive breastfeeding: only 29.7% of children were exclusively breastfed until they were six months. Therefore, the study seeks to understand, identify and quantify the situation determinants and provide information for the design of public policies. Material and method:: The study consisted of a cross-sectional descriptive anthropometric assessment in which the nutritional status and the prevalence of undernourishment, malnutrition and malnutrition in 141 children aged between six months and fi ve years, belonging to urban and rural regions of the country, were analyzed, as well as assessing the prevalence of breastfeeding in fi ve Honduran departments (Intibuca, Lempira, Atlantida, Olancho and Francisco Morazan). Results and conclusion: When making the analysis by departments, differences regarding nutritional status and breastfeeding were observed between urban and rural areas, the latter being doubled in the case of chronic malnutrition and underweight, with percentages of 14.6% in urban areas versus28.8% in rural areas, and 4.6% in urban areas compared to 9% in rural areas, respectively. However, with respect to acute malnutrition and overweight in both regions, similar values were observed, above 1.1% for acute and 14% for overweight malnutrition. In relation to exclusive breastfeeding for six months, the departments of Olancho and Lempira maintained it for two years, with a percentage distribution of 80% and 48%, respectively. It must be noted that 36% of mothers did not provide breastfeeding, with the highest rate (15%) in the department of Francisco Morazan. |
| Address |
. l.fernandezpalacios@um.es |
| Corporate Author |
|
Thesis |
|
| Publisher |
|
Place of Publication |
|
Editor |
|
| Language |
Spanish |
Summary Language |
|
Original Title |
Grado de malnutricion y su relacion con los principales factores estructurales y alimentarios de la poblacion preescolar hondurena. Prevalencia de la lactancia materna en los mismos |
| Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
| Series Volume |
|
Series Issue |
|
Edition |
|
| ISSN |
0212-1611 |
ISBN |
|
Medium |
|
| Area |
|
Expedition |
|
Conference |
|
| Notes |
PMID:28627201 |
Approved |
no |
| Call Number |
ref @ user @ |
Serial |
97083 |
| Permanent link to this record |
| |
|
| |
| Author |
Fernandez Palacios, L.; Barrientos Augustinus, E.; Raudales Urquia, C.; Frontela Saseta, C.; Ros Berruezo, G. |
| Title |
Degree of malnutrition and its relationship with major structural and eating factors in Honduran preschool population. Prevalence of breastfeeding |
Type |
Journal Article |
| Year |
2017 |
Publication |
Nutricion Hospitalaria |
Abbreviated Journal |
Nutr Hosp |
| Volume |
34 |
Issue |
3 |
Pages |
639-646 |
| Keywords |
*Honduras; *Child malnutrition; *Breastfeeding |
| Abstract |
Introduction: Child malnutrition remains a serious public health problem in Honduras, with a national prevalence according to the World Health Organization (WHO) reference values of 29% in children under fi ve. In addition, the average chronic malnutrition in the region amounts to 80% in poor and indigenous communities, making Honduras the second country in Central America with the highest incidence of chronic malnutrition. Another problem of the region is the early cessation of exclusive breastfeeding: only 29.7% of children were exclusively breastfed until they were six months. Therefore, the study seeks to understand, identify and quantify the situation determinants and provide information for the design of public policies. Material and method:: The study consisted of a cross-sectional descriptive anthropometric assessment in which the nutritional status and the prevalence of undernourishment, malnutrition and malnutrition in 141 children aged between six months and fi ve years, belonging to urban and rural regions of the country, were analyzed, as well as assessing the prevalence of breastfeeding in fi ve Honduran departments (Intibuca, Lempira, Atlantida, Olancho and Francisco Morazan). Results and conclusion: When making the analysis by departments, differences regarding nutritional status and breastfeeding were observed between urban and rural areas, the latter being doubled in the case of chronic malnutrition and underweight, with percentages of 14.6% in urban areas versus28.8% in rural areas, and 4.6% in urban areas compared to 9% in rural areas, respectively. However, with respect to acute malnutrition and overweight in both regions, similar values were observed, above 1.1% for acute and 14% for overweight malnutrition. In relation to exclusive breastfeeding for six months, the departments of Olancho and Lempira maintained it for two years, with a percentage distribution of 80% and 48%, respectively. It must be noted that 36% of mothers did not provide breastfeeding, with the highest rate (15%) in the department of Francisco Morazan. |
| Address |
. l.fernandezpalacios@um.es |
| Corporate Author |
|
Thesis |
|
| Publisher |
|
Place of Publication |
|
Editor |
|
| Language |
Spanish |
Summary Language |
|
Original Title |
Grado de malnutricion y su relacion con los principales factores estructurales y alimentarios de la poblacion preescolar hondurena. Prevalencia de la lactancia materna en los mismos |
| Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
| Series Volume |
|
Series Issue |
|
Edition |
|
| ISSN |
0212-1611 |
ISBN |
|
Medium |
|
| Area |
|
Expedition |
|
Conference |
|
| Notes |
PMID:28627201 |
Approved |
no |
| Call Number |
ref @ user @ |
Serial |
97123 |
| Permanent link to this record |
