| Records |
| Author |
Ribeiro, A.P.; Souza, E.R. de; Sousa, C.A.M. de |
| Title |
Injuries caused by firearms treated at Brazilian urgent and emergency healthcare services |
Type |
Journal Article |
| Year |
2017 |
Publication |
Ciencia & Saude Coletiva |
Abbreviated Journal |
Cien Saude Colet |
| Volume |
22 |
Issue  |
9 |
Pages |
2851-2860 |
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| Abstract |
This paper analyzes the medical care given at Brazilian urgent and emergency healthcare services to people injured by firearms in 2014. A cross-sectional study was carried out on care given to patients with firearms injuries in 24 capital cities of Brazilian states and in the Brazilian Federal District, included in the VIVA Survey. Simple and relative frequencies of the variables related to the patients and to the event were calculated, and a logistic model for complex samples was applied adopting care for firearms injuries patients as outcome. The results show the following percentages of care events as caused by firearms: 0.7% for the category 'other accidents (other than transport-related accidents)', 1.5% for self-inflicted injuries, 15.9% for injuries due to assault, and 65.1% of cases arising from legal intervention. The care given was predominantly to young male adults (age 20-39), of mixed race and with a low level of schooling. The most common injuries were: to arms and legs; and to multiple organs. The paper concludes by discussing the efforts to control firearms held by the public in Brazil, and how they can lead to severe and lethal outcomes in quarrels and interpersonal disputes. |
| Address |
Departamento de Estudos sobre Violencia e Saude Jorge Careli/Claves, Escola Nacional de Saude Publica, Fiocruz. Av. Brasil 4036/7 masculine, Manguinhos. 21040-210 Rio de Janeiro RJ Brasil. adalpeixoto@yahoo.com.br |
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| Language |
English |
Summary Language |
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Original Title |
Lesoes provocadas por armas de fogo atendidas em servicos de urgencia e emergencia brasileiros |
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Abbreviated Series Title |
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Edition |
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| ISSN |
1413-8123 |
ISBN |
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Conference |
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| Notes |
PMID:28954136 |
Approved |
no |
| Call Number |
ref @ user @ |
Serial |
97503 |
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| Author |
Villagra, P.; Quintana, C. |
| Title |
Disaster Governance for Community Resilience in Coastal Towns: Chilean Case Studies |
Type |
Journal Article |
| Year |
2017 |
Publication |
International Journal of Environmental Research and Public Health |
Abbreviated Journal |
Int J Environ Res Public Health |
| Volume |
14 |
Issue |
9 |
Pages |
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| Keywords |
community resilience; disaster governance; tsunami |
| Abstract |
This study aimed to further our understanding of a characteristic of Community Resilience known as Disaster Governance. Three attributes of Disaster Governance-redundancy, diversity, and overlap-were studied in four coastal towns in southern Chile that are at risk of tsunamis. Overall, we explored how different spatial structures of human settlements influence Disaster Governance. Using the Projective Mapping Technique, the distribution of emergency institutions (N = 32) and uses given to specific sites (e.g., for refuge, sanitary purposes and medical attention) were mapped. Content and GIS analyses (Directional Distribution and Kernel Density Index) were used to explore the dispersion and concentration of institutions and uses in each town. Disaster Governance was found to be highly influenced by decisions taken during regional, urban, and emergency planning. Governance is better in towns of higher order in the communal hierarchical structure. Most of the emergency institutions were found to be located in central and urban areas, which, in turn, assures more redundancy, overlap, and diversity in governance in the event of a tsunami. Lack of flexibility of emergency plans also limits governance in rural and indigenous areas. While the spatial relationships found in this study indicate that urban sectors have better Disaster Governance than rural and indigenous sectors, the influence of resource availability after tsunamis, the role and responsibility of different levels of governments, and the politics of disaster also play an important role in Disaster Governance for determining Community Resilience. These findings shed light on emergency planning and aspects of the Disaster Management cycle. |
| Address |
Laboratorio de Paisaje y Resiliencia Urbana, Universidad Austral de Chile, Valdivia 509000, Chile. contacto@pru-lab.cl |
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English |
Summary Language |
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Series Issue |
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Edition |
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| ISSN |
1660-4601 |
ISBN |
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Conference |
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| Notes |
PMID:28906480 |
Approved |
no |
| Call Number |
ref @ user @ |
Serial |
97628 |
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| Author |
Jahan, N.; Lee, J.M.; Shah, K.; Wakimoto, H. |
| Title |
Therapeutic targeting of chemoresistant and recurrent glioblastoma stem cells with a proapoptotic variant of oncolytic herpes simplex virus |
Type |
Journal Article |
| Year |
2017 |
Publication |
International Journal of Cancer |
Abbreviated Journal |
Int J Cancer |
| Volume |
141 |
Issue |
8 |
Pages |
1671-1681 |
| Keywords |
Animals; Apoptosis/physiology; Brain Neoplasms/drug therapy/*therapy/virology; Cell Line, Tumor; Cohort Studies; Dacarbazine/analogs & derivatives/pharmacology; Drug Resistance, Neoplasm; Glioblastoma/drug therapy/*therapy/virology; HEK293 Cells; Humans; Mice; Neoplasm Recurrence, Local/drug therapy/therapy/virology; Neoplastic Stem Cells/drug effects/pathology/*virology; Oncolytic Virotherapy/*methods; Simplexvirus/genetics/*physiology; TNF-Related Apoptosis-Inducing Ligand/biosynthesis/genetics; TNF-related apoptosis inducing ligand (TRAIL); glioblastoma; oncolytic herpes simplex virus; recurrence; temozolomide |
| Abstract |
Temozolomide (TMZ) chemotherapy, in combination with maximal safe resection and radiotherapy, is the current standard of care for patients with glioblastoma (GBM). Despite this multimodal approach, GBM inevitably relapses primarily due to resistance to chemo-radiotherapy, and effective treatment is not available for recurrent disease. In this study we identified TMZ resistant patient-derived primary and previously treated recurrent GBM stem cells (GSC), and investigated the therapeutic activity of a pro-apoptotic variant of oHSV (oHSV-TRAIL) in vitro and in vivo. We show that oHSV-TRAIL modulates cell survival and MAP Kinase proliferation signaling pathways as well as DNA damage response pathways in both primary and recurrent TMZ-resistant GSC. Utilizing real time in vivo imaging and correlative immunohistochemistry, we show that oHSV-TRAIL potently inhibits tumor growth and extends survival of mice bearing TMZ-insensitive recurrent intracerebral GSC tumors via robust and selective induction of apoptosis-mediated death in tumor cells, resulting in cures in 40% of the treated mice. In comparison, the anti-tumor effects in a primary chemoresistant GSC GBM model exhibiting a highly invasive phenotype were significant but less prominent. This work thus demonstrates the ability of oHSV-TRAIL to overcome the therapeutic resistance and recurrence of GBM, and provides a basis for its testing in a GBM clinical trial. |
| Address |
Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA |
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Place of Publication |
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English |
Summary Language |
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Abbreviated Series Title |
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| ISSN |
0020-7136 |
ISBN |
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Conference |
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| Notes |
PMID:28567859 |
Approved |
no |
| Call Number |
ref @ user @ |
Serial |
96584 |
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| Author |
D'Alessandris, Q.G.; Biffoni, M.; Martini, M.; Runci, D.; Buccarelli, M.; Cenci, T.; Signore, M.; Stancato, L.; Olivi, A.; De Maria, R.; Larocca, L.M.; Ricci-Vitiani, L.; Pallini, R. |
| Title |
The clinical value of patient-derived glioblastoma tumorspheres in predicting treatment response |
Type |
Journal Article |
| Year |
2017 |
Publication |
Neuro-Oncology |
Abbreviated Journal |
Neuro Oncol |
| Volume |
19 |
Issue |
8 |
Pages |
1097-1108 |
| Keywords |
cancer stem cells; glioblastoma; radiotherapy; temozolomide; treatment outcome |
| Abstract |
Background: Advances from glioma stemlike cell (GSC) research, though increasing our knowledge of glioblastoma (GBM) biology, do not influence clinical decisions yet. We explored the translational power of GSC-enriched cultures from patient-derived tumorspheres (TS) in predicting treatment response. Methods: The relationship between TS growth and clinical outcome was investigated in 52 GBMs treated with surgical resection followed by radiotherapy and temozolomide (TMZ). The effect on TS of radiation (6 to 60 Gy) and of TMZ (3.9 muM to 1 mM) was related with patients' survival. Results: Generation of TS was an independent factor for poor overall survival (OS) and poor progression-free survival (PFS) (P < .0001 and P = .0010, respectively). Growth rate and clonogenicity of TS predicted poor OS. In general, TS were highly resistant to both radiation and TMZ. Resistance to TMZ was stronger in TS with high clonogenicity and fast growth (P < .02). Shorter PFS was associated with radiation LD50 (lethal dose required to kill 50% of TS cells) >12 Gy of matched TS (P = .0484). A direct relationship was found between sensitivity of TS to TMZ and patients' survival (P = .0167 and P = .0436 for OS and PFS, respectively). Importantly, values for TMZ half-maximal inhibitory concentration <50 muM, which are in the range of plasma levels achieved in vivo, identified cases with longer OS and PFS (P = .0020 and P = .0016, respectively). Conclusions: Analysis of TS holds translational relevance by predicting the response of parent tumors to radiation and, particularly, to TMZ. Dissecting the clonogenic population from proliferating progeny in TS can guide therapeutic strategies to a more effective drug selection and treatment duration. |
| Address |
Institute of Neurosurgery, Universita Cattolica del Sacro Cuore, Rome, Italy; Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanita, Rome, Italy; Institute of Pathology, Universita Cattolica del Sacro Cuore, Rome, Italy; Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana |
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English |
Summary Language |
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Series Issue |
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Edition |
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| ISSN |
1522-8517 |
ISBN |
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Conference |
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| Notes |
PMID:28204560 |
Approved |
no |
| Call Number |
ref @ user @ |
Serial |
96607 |
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| Author |
Girardi, S.N.; Carvalho, C.L.; Maas, L.W.D.; Araujo, J.F.; Massote, A.W.; Stralen, A.C. de S. van; Souza, O.A. de |
| Title |
[Preferences for work in primary care among medical students in Minas Gerais State, Brazil: evidence from a discrete choice experiment] |
Type |
Journal Article |
| Year |
2017 |
Publication |
Cadernos de Saude Publica |
Abbreviated Journal |
Cad Saude Publica |
| Volume |
33 |
Issue |
8 |
Pages |
e00075316 |
| Keywords |
Brazil; *Career Choice; Choice Behavior; Female; Humans; Income; Male; *Primary Health Care; *Professional Practice Location; Sex Factors; *Students, Medical; Surveys and Questionnaires |
| Abstract |
This article presents the results of a discrete choice experiment (DCE) conducted in 2012 with 277 final-year medical students from Minas Gerais State, Brazil. The experiment tested students' preferences concerning future work as physicians in primary health care, based on hypothetical job scenarios aimed at measuring the likelihood of placement in areas with a shortage of doctors. Application of DCE involved (i) a qualitative stage to define the attributes and their respective levels to comprise the job scenarios, (ii) construction and application of the instrument, and (iii) analysis with application of multinomial logit with conditional probability to estimate the weight of attributes and to construct scenarios for choice probability. The results indicate that the job attribute that most impacted students' choice was location, followed by job conditions, pay, access to medical residency, type of employment relationship, and workload. Students from private medical schools, with higher family income, and females were generally more likely to resist job assignments in unsafe urban areas and remote areas of the countryside. The job scenarios that proved most plausible in terms of public intervention were those that combined middle-level wages, good working conditions, and 10 to 20 bonus points on medical residency exams. |
| Address |
Departamento de Matematica, Universidade Estadual do Centro-Oeste, Guarapuava, Brasil |
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Place of Publication |
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| Language |
Portuguese |
Summary Language |
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Original Title |
Preferencias para o trabalho na atencao primaria por estudantes de medicina em Minas Gerais, Brasil: evidencias de um experimento de preferencia declarada |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
0102-311X |
ISBN |
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Medium |
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Expedition |
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Conference |
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| Notes |
PMID:28832780 |
Approved |
no |
| Call Number |
ref @ user @ |
Serial |
97630 |
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