| Records |
| Author |
Rocha, G. da S.; Mello Jorge, M.H.P. de; Grembek, O. |
| Title |
After-effects and disabilities in traffic crash victims in northern Brazil |
Type |
Journal Article |
| Year |
2017 |
Publication |
Traffic Injury Prevention |
Abbreviated Journal |
Traffic Inj Prev |
| Volume |
18 |
Issue  |
4 |
Pages |
412-419 |
| Keywords |
Accidents, Traffic/*statistics & numerical data; Adolescent; Adult; Aged; Brazil/epidemiology; Child; Cities; Cross-Sectional Studies; *Disabled Persons; Facial Injuries/epidemiology/mortality/pathology; Female; Humans; Injury Severity Score; Logistic Models; Male; Middle Aged; Motorcycles; Odds Ratio; Risk Factors; Wounds and Injuries/*epidemiology/mortality/pathology; Young Adult; Crashes; after-effects; severity of trauma; traffic; victims |
| Abstract |
OBJECTIVES: The objective of this study was to identify the characteristics related to crash and victim, as well as the after-effects/disabilities and consequences arising from traffic crashes occurring in the city of Rio Branco-Acre. METHODS: This is an analytical descriptive cross-sectional study conducted in the City of Rio Branco-Acre. The study population consisted of 405 residents of the city who were victims of traffic crashes, of all age groups and genders, who were hospitalized for the first time as a result of the crash in public hospitals and the health system network, as recorded in the Hospital Information System, and who were discharged between January 1 and December 31, 2010. The data sources included hospital record consultations and active searches for the victims. Hierarchical logistic regression was performed to evaluate the factors associated with the after-effects. RESULTS: The majority of the study population was motorcycle victims (68.6%), male, and young (20-39 years). Concerning the after-effects, the following were significantly associated: factors related to the presence of a postcrash activity limitation (odds ratio [OR] = 2.39; 95% confidence interval [CI], 2.39-6.76), length of hospital stay in days (OR = 1 03; 95% CI, 1.01-1.06), and surgical treatment (OR = 1.82; 95% CI, 1.03-3.21). Those who suffered damage to soft tissue and nerves or facial injury showed an odds ratio of 2 to 4 times of having an after-effect/disability, independent of the victim's personal attributes. CONCLUSION: The mechanism, such as the origin of the pattern of injuries, explains the exposure factors shown by each attribute of the victim and their characteristics. Many of the injuries were precursors to after-effects/disabilities, which, due to their nature and extent, result in the modification of the apparently healthy living standards of young victims who are routinely injured in traffic crashes. Therefore, public policies for prevention should be formulated, reformulated, and implemented, taking into account each attribute of the victims and their social conditions, because these are closely related to their habits and customs. This is a starting point for promoting changes to the current reality that traffic crashes present in the morbidity and mortality of the population. |
| Address |
c University of California , Berkeley , Safe Transportation Research and Education Center , Berkeley , California |
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English |
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| ISSN |
1538-9588 |
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| Notes |
PMID:27575383 |
Approved |
no |
| Call Number |
ref @ user @ |
Serial |
97666 |
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| Author |
Blot, S.; Bauer, G.; Fraser, M.; Nleya, M.; Wadham, M. |
| Title |
AIDS Service Organization Access Among African, Caribbean and Other Black Residents of an Average Canadian City |
Type |
Journal Article |
| Year |
2017 |
Publication |
Journal of Immigrant and Minority Health |
Abbreviated Journal |
J Immigr Minor Health |
| Volume |
19 |
Issue |
4 |
Pages |
851-860 |
| Keywords |
African; Black people; Caribbean; Hiv/Aids; Health disparities; Health services research; Immigrant health; Minority health |
| Abstract |
Due to heightened vulnerability to HIV/AIDS, African, Caribbean and Black (ACB) communities are priority groups for prevention and intervention services in Canada. However, it is not clear which factors may affect ACB communities' access to these services. We evaluated access to the local AIDS service organization (ASO) in Middlesex-London by using data from the Black, African and Caribbean Canadian Health Study. Modified Poisson regression was used to obtain prevalence risk ratios for factors associated with three measures of access: familiarity with the ASO, willingness to access, and realized access. In adjusted analyses, older ACB community members were more likely to be familiar with the ASO, willing to access it, and have actually gone there. Canadian-born participants were less likely to have been to the ASO than recent immigrants. These results have implications for reaching specific segments of ACB communities for HIV/AIDS-related services in Canada. |
| Address |
Women and HIV/AIDS Initiative, Toronto, ON, Canada |
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English |
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Edition |
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| ISSN |
1557-1912 |
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| Notes |
PMID:26895153 |
Approved |
no |
| Call Number |
ref @ user @ |
Serial |
97682 |
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| Author |
Li, M.; Xiao, A.; Floyd, D.; Olmez, I.; Lee, J.; Godlewski, J.; Bronisz, A.; Bhat, K.P.L.; Sulman, E.P.; Nakano, I.; Purow, B. |
| Title |
CDK4/6 inhibition is more active against the glioblastoma proneural subtype |
Type |
Journal Article |
| Year |
2017 |
Publication |
Oncotarget |
Abbreviated Journal |
Oncotarget |
| Volume |
8 |
Issue |
33 |
Pages |
55319-55331 |
| Keywords |
Cdk4/6; glioblastoma; mesenchymal; palbociclib; proneural |
| Abstract |
Glioblastoma (GBM) is the most common and lethal brain tumor. Gene expression profiling has classified GBM into distinct subtypes, including proneural, mesenchymal, and classical, and identifying therapeutic vulnerabilities of these subtypes is an extremely high priority. We leveraged The Cancer Genome Atlas (TCGA) data, in particular for microRNA expression, to seek druggable core pathways in GBM. The E2F1-regulated miR-17 92 cluster and its analogs are shown to be highly expressed in proneural GBM and in GSC lines, suggesting the E2F cell cycle pathway might be a key driver in proneural GBM. Consistently, CDK4/6 inhibition with palbociclib preferentially inhibited cell proliferation in vitro in a majority of proneural GSCs versus those of other subtypes. Palbociclib treatment significantly prolonged survival of mice with established intracranial xenografts of a proneural GSC line. We show that most of these sensitive PN GSCs expressed higher levels of CDK6 and had intact Rb1, while two GSC lines with CDK4 overexpression and null Rb1 were highly resistant to palbociclib. Importantly, palbociclib treatment of proneural GSCs upregulated mesenchymal-associated markers and downregulated proneural-associated markers, suggesting that CDK4/6 inhibition induced proneural-mesenchymal transition and underscoring the enhanced role of the E2F cell cycle pathway in the proneural subtype. Lastly, the combination of palbociclib and N,N-diethylaminobenzaldehyde, an inhibitor of the mesenchymal driver ALDH1A3, showed strong synergistic inhibitory effects against proneural GSC proliferation. Taken together, our results reveal that proneural GBM has increased vulnerability to CDK4/6 inhibition, and the proneural subtype undergoes dynamic reprogramming upon palbociclib treatment-suggesting the need for a combination therapeutic strategy. |
| Address |
Neuro-Oncology Division, Department of Neurology, University of Virginia, Charlottesville, VA, USA |
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English |
Summary Language |
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Edition |
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| ISSN |
1949-2553 |
ISBN |
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Expedition |
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Conference |
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| Notes |
PMID:28903422 |
Approved |
no |
| Call Number |
ref @ user @ |
Serial |
96569 |
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| Author |
Gredilla, A.; Fdez-Ortiz de Vallejuelo, S.; Gomez-Nubla, L.; Carrero, J.A.; de Leao, F.B.; Madariaga, J.M.; Silva, L.F.O. |
| Title |
Are children playgrounds safe play areas? Inorganic analysis and lead isotope ratios for contamination assessment in recreational (Brazilian) parks |
Type |
Journal Article |
| Year |
2017 |
Publication |
Environmental Science and Pollution Research International |
Abbreviated Journal |
Environ Sci Pollut Res Int |
| Volume |
24 |
Issue |
31 |
Pages |
24333-24345 |
| Keywords |
Chemometric analysis; Human health; Icp-Ms; Lead isotopic ratio; Metals; Normalized-and-Weighted Average Concentration; Playgrounds |
| Abstract |
In city playgrounds, there is a potential risk of harming children's health by contamination coming from anthropogenic activities. With the aim to determinate the sources and the risk of hazardous elements, soil samples were collected in 19 selected playgrounds of different urban and rural areas from the Rio Grande do Sul state (Brazil). The concentration of 23 metals and metalloids and lead isotopic ratios were determined by ICP-MS. The methodology proposed here, firstly, classified the parks according to the average metal content by means of the NWACs (Normalized-and-Weighted Average Concentrations) and assess the contamination risk determining the Contamination Factors (CFs). Finally, statistical tools (correlation analysis and principal component analysis) were used to identify the most important contamination sources. The statistical tools used, together with lead isotopic composition analysis of the samples, revealed that coal combustion is the main source of contamination in the area. Vegetation was identified as a barrier for the contamination coming from the city. Nonetheless, some of the soils present a possible toxicological risk for humans. In fact, Cr, Sb, and Pb concentrations were higher than the Residential Intervention Values (VIRs) defined by the Environmental Protection Agency of the State of Sao Paulo, also in Brazil. |
| Address |
Research Group in Environmental Management and Sustainability, Faculty of Environmental Sciences, Universidad De la Costa, Calle 58, No. 55-56, 080002, Barranquilla, Atlantico, Colombia |
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Place of Publication |
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English |
Summary Language |
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Original Title |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
0944-1344 |
ISBN |
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Medium |
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Expedition |
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Conference |
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| Notes |
PMID:28889400 |
Approved |
no |
| Call Number |
ref @ user @ |
Serial |
97629 |
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| Author |
Magrath, J.W.; Kim, Y. |
| Title |
Salinomycin's potential to eliminate glioblastoma stem cells and treat glioblastoma multiforme (Review) |
Type |
Journal Article |
| Year |
2017 |
Publication |
International Journal of Oncology |
Abbreviated Journal |
Int J Oncol |
| Volume |
51 |
Issue |
3 |
Pages |
753-759 |
| Keywords |
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| Abstract |
Glioblastoma multiforme (GBM) is the most common and deadliest form of primary brain tumor. Despite treatment with surgery, radiotherapy, and chemotherapy with the drug temozolomide, the expected survival after diagnosis remains low. The median survival is only 14.6 months and the two-year survival is a mere 30%. One reason for this is the heterogeneity of GBM including the presence of glioblastoma cancer stem cells (GSCs). GSCs are a subset of cells with the unique ability to proliferate, differentiate, and create tumors. GSCs are resistant to chemotherapy and radiation and thought to play an important role in recurrence. In order to effectively treat GBM, a drug must be identified that can kill GSCs. The ionophore salinomycin has been shown to kill cancer stem cells and is therefore a promising future treatment for GBM. This study focuses on salinomycin's potential to treat GBM including its ability to reduce the CSC population, its toxicity to normal brain cells, its mechanism of action, and its potential for combination treatment. |
| Address |
Department of Chemical and Biological Engineering, The University of Alabama, Tuscaloosa, AL 35487-0203, USA |
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English |
Summary Language |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
1019-6439 |
ISBN |
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Conference |
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| Notes |
PMID:28766685 |
Approved |
no |
| Call Number |
ref @ user @ |
Serial |
96573 |
| Permanent link to this record |
