toggle visibility Search & Display Options

Select All    Deselect All
 |   | 
Details
   print
  Records Links
Author Gersey, Z.C.; Rodriguez, G.A.; Barbarite, E.; Sanchez, A.; Walters, W.M.; Ohaeto, K.C.; Komotar, R.J.; Graham, R.M. url  doi
openurl 
  Title Curcumin decreases malignant characteristics of glioblastoma stem cells via induction of reactive oxygen species Type Journal Article
  Year 2017 Publication BMC Cancer Abbreviated Journal BMC Cancer  
  Volume 17 Issue 1 Pages 99  
  Keywords (up) Acetylcysteine/pharmacology; Adult; Antineoplastic Agents/*pharmacology; Cell Proliferation/drug effects; Cell Survival/drug effects; Curcumin/*pharmacology; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Free Radical Scavengers; Glioblastoma/drug therapy/pathology; Humans; Inhibitor of Apoptosis Proteins/metabolism; Inhibitory Concentration 50; Mitogen-Activated Protein Kinases/metabolism; Neoplastic Stem Cells/*drug effects; Oxidative Stress; Reactive Oxygen Species/*metabolism; STAT3 Transcription Factor/metabolism; Tumor Cells, Cultured; Brain tumor; Curcumin; Glioblastoma; Natural product; Reactive oxygen species; Stat3; Stem cell  
  Abstract BACKGROUND: Glioblastoma Multiforme (GBM) is the most common and lethal form of primary brain tumor in adults. Following standard treatment of surgery, radiation and chemotherapy, patients are expected to survive 12-14 months. Theorized cause of disease recurrence in these patients is tumor cell repopulation through the proliferation of treatment-resistant cancer stem cells. Current research has revealed curcumin, the principal ingredient in turmeric, can modulate multiple signaling pathways important for cancer stem cell self-renewal and survival. METHODS: Following resection, tumor specimens were dissociated and glioblastoma stem cells (GSCs) were propagated in neurosphere media and characterized via immunocytochemistry. Cell viability was determined with MTS assay. GSC proliferation, sphere forming and colony forming assays were conducted through standard counting methods. Reactive oxygen species (ROS) production was examined using the fluorescent molecular probe CM-H2DCFA. Effects on cell signaling pathways were elucidated by western blot. RESULTS: We evaluate the effects of curcumin on patient-derived GSC lines. We demonstrate a curcumin-induced dose-dependent decrease in GSC viability with an approximate IC50 of 25 muM. Treatment with sub-toxic levels (2.5 muM) of curcumin significantly decreased GSC proliferation, sphere forming ability and colony forming potential. Curcumin induced ROS, promoted MAPK pathway activation, downregulated STAT3 activity and IAP family members. Inhibition of ROS with the antioxidant N-acetylcysteine reversed these effects indicating a ROS dependent mechanism. CONCLUSIONS: Discoveries made in this investigation may lead to a non-toxic intervention designed to prevent recurrence in glioblastoma by targeting glioblastoma stem cells.  
  Address Department of Neurological Surgery, University of Miami Brain Tumor Initiative (UMBTI) Research Laboratory, Lois Pope LIFE Center, 2nd Floor, 1095 NW 14th Terrace, Miami, Florida, 33136, USA. rgraham@med.miami.edu  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1471-2407 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:28160777 Approved no  
  Call Number ref @ user @ Serial 96610  
Permanent link to this record
 

 
Author Miguel, M.G.; Barreto, R.P.; Pereira, S.Y. url  doi
openurl 
  Title Study of a tropical soil in order to use it to retain aluminum, iron, manganese and fluoride from acid mine drainage Type Journal Article
  Year 2017 Publication Journal of Environmental Management Abbreviated Journal J Environ Manage  
  Volume 204 Issue Pt 1 Pages 563-570  
  Keywords (up) Acid mine drainage; Column test; Contaminant transport; Liner; Tropical soils; Waste rock pile  
  Abstract The Ore Treatment Unit (UTM-Caldas), in the city of Caldas, Minas Gerais, Brazil, nowadays in decommissioning stage, was the first uranium extraction mine in Brazil. Several negative environmental impacts in the area have occurred, because of mining, treatment and beneficiation processes. Waste rock pile 4 (WRP-4) generates acid mine drainage (AMD), which is discharged in the Nestor Figueiredo retention pond (NFP). However, leakage of acid water by the NFP dam foundation has been constantly observed. Therefore, this research aimed to investigate a typical tropical soil, in order to use it as mineral liner for the NFP to minimize the leakage of acid water through the dam foundation and to retain predominant chemical species. Geotechnical, chemical and mineralogical tests were performed to characterize the soil and a column test was carried out using the acid mine drainage as contaminant, which contained aluminum (Al), manganese (Mn), iron (Fe) and fluoride (F-). The soil presented micro aggregation, acid pH, and low values of organic matter content and cation exchange capacity, which are characteristics of highly weathered soils. Diffusion was the predominant transport mechanism in the column test. Effluent solutions with pH less than 6.0 indicated the formation of insoluble Al-F complexes in the soil and desorption of iron and manganese at concentrations above those allowed by the Brazilian legislation. At pH greater than 6.0, the desorption of iron and manganese and release of aluminum and fluoride in the free form occurred, with concentrations also higher than the allowed by the Brazilian legislation.  
  Address Institute of Geoscience, University of Campinas (Unicamp), Brazil  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0301-4797 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:28942188 Approved no  
  Call Number ref @ user @ Serial 97504  
Permanent link to this record
 

 
Author Ramirez-Blanco, C.E.; Ramirez-Rivero, C.E.; Diaz-Martinez, L.A.; Sosa-Avila, L.M. url  doi
openurl 
  Title Infection in burn patients in a referral center in Colombia Type Journal Article
  Year 2017 Publication Burns : Journal of the International Society for Burn Injuries Abbreviated Journal Burns  
  Volume 43 Issue 3 Pages 642-653  
  Keywords (up) Acinetobacter Infections/drug therapy/epidemiology/microbiology; Acinetobacter baumannii; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents/therapeutic use; Bacteremia/drug therapy/*epidemiology/microbiology; Burns/*epidemiology; Catheter-Related Infections/drug therapy/*epidemiology/microbiology; Central Venous Catheters; Cephalosporins/therapeutic use; Child; Child, Preschool; Colombia/epidemiology; Drug Resistance, Microbial; Escherichia coli; Escherichia coli Infections/drug therapy/epidemiology/microbiology; Female; Folliculitis/drug therapy/*epidemiology/microbiology; Humans; Infant; Infant, Newborn; Klebsiella Infections/drug therapy/epidemiology/microbiology; Klebsiella pneumoniae; Male; Middle Aged; Oxacillin/therapeutic use; Pneumonia/drug therapy/*epidemiology/microbiology; Pseudomonas Infections/drug therapy/epidemiology/microbiology; Pseudomonas aeruginosa; Staphylococcal Infections/drug therapy/epidemiology/microbiology; Staphylococcus aureus; Urinary Tract Infections/drug therapy/*epidemiology/microbiology; Wound Infection/drug therapy/*epidemiology/microbiology; Young Adult; Burn wound infection; Burns; Health care related infection; Nosocomial infection; Pneumonia; Urinary tract infection  
  Abstract INTRODUCTION: Worldwide, burns are responsible for more than 300,000 deaths annually; infection is a major cause of morbidity and mortality in these patients. Early identification and treatment of infection improves outcome. Toward this end it's necessary to identify the institutions flora and organisms that most frequently produces infection. OBJECTIVES: To characterize infections developed by burn patients hospitalized at the University Hospital of Santander (HUS). METHODOLOGY: Burn patients hospitalized in the HUS from January 1 to December 2014 were followed. Medical information regarding infections, laboratory and pathology reports were obtained. Statistical analysis with measures of central tendency, proportions, global and specific incidence density plus overall and specific incidence was obtained. For the microbiological profile proportions were established. RESULTS: 402 burn patients were included, 234 (58.2%) men and 168 (41.8%) women, aged between 6 days and 83 years, median 12.5 years. The burn agents include scald (52.5%), fire (10.0%), gasoline (9.2%), electricity (7.5%), among others. Burn area ranged from 1% to 80% TBS. Cumulative mortality was 1.5%. 27.8% of burned patients had one or more infections. Identified infections include folliculitis (27.0%), urinary tract infection (19.0%), infection of the burn wound (10.4%), pneumonia (8.6%), Central venous catheter (7.4%), bloodstream infection (7.4%) and skin grafts infection (4.3%) among others. Bacteria were responsible for 88.5% of the cases and fungi 11.5%. The most frequently isolated germs were P. aeruginosa, A. baumannii, E. coli, S. aureus and K. pneumoniae. Most gram-negative bacteria were sensitive to Amikacin, gram positive bacteria were sensitive to multiple antibiotics. CONCLUSION: Burns is a severe trauma that occurs in adult and pediatric patients, has several causative agents and can compromise the patient's life. The burned patient is at risk for a variety of infections. According to the type of infection it is possible to infer the most common causative organisms and their antibiotic sensitivity/resistance which allow a directed early empiric treatment.  
  Address University Hospital of Santander, Universidad Industrial de Santander, Colombia. Electronic address: lumisosa@gmail.com  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0305-4179 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:28185802 Approved no  
  Call Number ref @ user @ Serial 99267  
Permanent link to this record
 

 
Author Ramirez-Blanco, C.E.; Ramirez-Rivero, C.E.; Diaz-Martinez, L.A.; Sosa-Avila, L.M. url  doi
openurl 
  Title Infection in burn patients in a referral center in Colombia Type Journal Article
  Year 2017 Publication Burns : Journal of the International Society for Burn Injuries Abbreviated Journal Burns  
  Volume 43 Issue 3 Pages 642-653  
  Keywords (up) Acinetobacter Infections/drug therapy/epidemiology/microbiology; Acinetobacter baumannii; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents/therapeutic use; Bacteremia/drug therapy/*epidemiology/microbiology; Burns/*epidemiology; Catheter-Related Infections/drug therapy/*epidemiology/microbiology; Central Venous Catheters; Cephalosporins/therapeutic use; Child; Child, Preschool; Colombia/epidemiology; Drug Resistance, Microbial; Escherichia coli; Escherichia coli Infections/drug therapy/epidemiology/microbiology; Female; Folliculitis/drug therapy/*epidemiology/microbiology; Humans; Infant; Infant, Newborn; Klebsiella Infections/drug therapy/epidemiology/microbiology; Klebsiella pneumoniae; Male; Middle Aged; Oxacillin/therapeutic use; Pneumonia/drug therapy/*epidemiology/microbiology; Pseudomonas Infections/drug therapy/epidemiology/microbiology; Pseudomonas aeruginosa; Staphylococcal Infections/drug therapy/epidemiology/microbiology; Staphylococcus aureus; Urinary Tract Infections/drug therapy/*epidemiology/microbiology; Wound Infection/drug therapy/*epidemiology/microbiology; Young Adult; Burn wound infection; Burns; Health care related infection; Nosocomial infection; Pneumonia; Urinary tract infection  
  Abstract INTRODUCTION: Worldwide, burns are responsible for more than 300,000 deaths annually; infection is a major cause of morbidity and mortality in these patients. Early identification and treatment of infection improves outcome. Toward this end it's necessary to identify the institutions flora and organisms that most frequently produces infection. OBJECTIVES: To characterize infections developed by burn patients hospitalized at the University Hospital of Santander (HUS). METHODOLOGY: Burn patients hospitalized in the HUS from January 1 to December 2014 were followed. Medical information regarding infections, laboratory and pathology reports were obtained. Statistical analysis with measures of central tendency, proportions, global and specific incidence density plus overall and specific incidence was obtained. For the microbiological profile proportions were established. RESULTS: 402 burn patients were included, 234 (58.2%) men and 168 (41.8%) women, aged between 6 days and 83 years, median 12.5 years. The burn agents include scald (52.5%), fire (10.0%), gasoline (9.2%), electricity (7.5%), among others. Burn area ranged from 1% to 80% TBS. Cumulative mortality was 1.5%. 27.8% of burned patients had one or more infections. Identified infections include folliculitis (27.0%), urinary tract infection (19.0%), infection of the burn wound (10.4%), pneumonia (8.6%), Central venous catheter (7.4%), bloodstream infection (7.4%) and skin grafts infection (4.3%) among others. Bacteria were responsible for 88.5% of the cases and fungi 11.5%. The most frequently isolated germs were P. aeruginosa, A. baumannii, E. coli, S. aureus and K. pneumoniae. Most gram-negative bacteria were sensitive to Amikacin, gram positive bacteria were sensitive to multiple antibiotics. CONCLUSION: Burns is a severe trauma that occurs in adult and pediatric patients, has several causative agents and can compromise the patient's life. The burned patient is at risk for a variety of infections. According to the type of infection it is possible to infer the most common causative organisms and their antibiotic sensitivity/resistance which allow a directed early empiric treatment.  
  Address University Hospital of Santander, Universidad Industrial de Santander, Colombia. Electronic address: lumisosa@gmail.com  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0305-4179 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:28185802 Approved no  
  Call Number ref @ user @ Serial 100297  
Permanent link to this record
 

 
Author Monge-Rojas, R.; Fuster-Baraona, T.; Garita-Arce, C.; Sanchez-Lopez, M.; Colon-Ramos, U.; Smith-Castro, V. url  doi
openurl 
  Title How Self-Objectification Impacts Physical Activity Among Adolescent Girls in Costa Rica Type Journal Article
  Year 2017 Publication Journal of Physical Activity & Health Abbreviated Journal J Phys Act Health  
  Volume 14 Issue 2 Pages 123-129  
  Keywords (up) Adolescent; *Adolescent Behavior; Body Image/*psychology; Costa Rica; Cultural Characteristics; *Exercise; Female; Focus Groups; Humans; Male; Women's Health; Latin America; female identity; machismo; sexual harassment  
  Abstract BACKGROUND: In Latin America, more than 80% of adolescent girls are physically inactive. Inactivity may be reinforced by female stereotypes and objectification in the Latin American sociocultural context. METHODS: We examined the influence of objectification on the adoption of an active lifestyle among 192 adolescents (14 and 17 years old) from urban and rural areas in Costa Rica. Analyses of 48 focus-groups sessions were grounded in Objectification Theory. RESULTS: Vigorous exercises were gender-typed as masculine while girls had to maintain an aesthetic appearance at all times. Adolescents described how girls were anxious around the prospect of being shamed and sexually objectified during exercises. This contributed to a decrease in girls' desire to engage in physical activities. Among males, there is also a budding tolerance of female participation in vigorous sports, as long as girls maintained a feminine stereotype outside their participation. CONCLUSION: Self-objectification influenced Costa Rican adolescent girls' decisions to participate in physical activities. Interventions may include: procuring safe environments for physical activity where girls are protected from fear of ridicule and objectification; sensitizing boys about girl objectification and fostering the adoption of a modern positive masculine and female identities to encourage girls' participation in sports.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1543-3080 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:27775480 Approved no  
  Call Number ref @ user @ Serial 97269  
Permanent link to this record
Select All    Deselect All
 |   | 
Details
   print

Save Citations:
Export Records: