| Records |
| Author |
Azoulay, M.; Santos, F.; Shenouda, G.; Petrecca, K.; Oweida, A.; Guiot, M.C.; Owen, S.; Panet-Raymond, V.; Souhami, L.; Abdulkarim, B.S. |
| Title |
Benefit of re-operation and salvage therapies for recurrent glioblastoma multiforme: results from a single institution |
Type |
Journal Article |
| Year |
2017 |
Publication |
Journal of Neuro-Oncology |
Abbreviated Journal |
J Neurooncol |
| Volume |
132 |
Issue |
3 |
Pages |
419-426 |
| Keywords |
Bevacizumab; Glioblastoma; Radiation; Recurrence; Surgery; Temozolomide |
| Abstract |
The optimal management of recurrent glioblastoma (GBM) has yet to be determined. We aim to assess the benefits of re-operation and salvage therapies (chemotherapy and/or re-irradiation) for recurrent GBM and to identify prognostic factors associated with better survival. All patients who underwent surgery for GBM between January 2005 and December 2012 followed by adjuvant radiotherapy, and who developed GBM recurrence on imaging were included in this retrospective study. Univariate and multivariate analysis was performed using Cox models in order to identify factors associated with overall survival (OS). One hundred and eighty patients treated to a dose of 60 Gy were diagnosed with recurrent GBM. At a median follow-up time of 6.2 months, the median survival (MS) from time of recurrence was 6.6 months. Sixty-nine patients underwent repeat surgery for recurrence based on imaging. To establish the benefits of repeat surgery and salvage therapies, 68 patients who underwent repeat surgery were matched to patients who did not based on extent of initial resection and presence of subventricular zone involvement at recurrence. MS for patients who underwent re-operation was 9.6 months, compared to 5.3 months for patients who did not have repeat surgery (p < 0.0001). Multivariate analysis in the matched pairs confirmed that repeat surgery with the addition of other salvage treatment can significantly affect patient outcome (HR 0.53). Re-operation with additional salvage therapies for recurrent GBM provides survival prolongation at the time of progression. |
| Address |
Department of Oncology, Division of Radiation Oncology, Cedars Cancer Centre, McGill University Health Centre, 1001 Decarie Boulevard, Montreal, QC, H4A 3J1, Canada. bassam.abdulkarim@mcgill.ca |
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English |
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0167-594X |
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PMID:28374095 |
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no |
| Call Number |
ref @ user @ |
Serial |
96599 |
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| Author |
de Sousa, J.F.; Torrieri, R.; Serafim, R.B.; Di Cristofaro, L.F.M.; Escanfella, F.D.; Ribeiro, R.; Zanette, D.L.; Paco-Larson, M.L.; da Silva, W.A.J.; Tirapelli, D.P. da C.; Neder, L.; Carlotti, C.G.J.; Valente, V. |
| Title |
Expression signatures of DNA repair genes correlate with survival prognosis of astrocytoma patients |
Type |
Journal Article |
| Year |
2017 |
Publication |
Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine |
Abbreviated Journal |
Tumour Biol |
| Volume |
39 |
Issue |
4 |
Pages |
1010428317694552 |
| Keywords |
Apoptosis; Astrocytoma/genetics/metabolism/*mortality; Brain Neoplasms/genetics/metabolism/*mortality; Cell Cycle; Cell Line, Tumor; *DNA Repair; DNA Repair Enzymes/genetics/metabolism; Exodeoxyribonucleases/genetics/metabolism; Gene Expression; Humans; Kaplan-Meier Estimate; N-Glycosyl Hydrolases/genetics/metabolism; Prognosis; DNA repair; astrocytoma; genomic instability; glioblastoma; tumor progression |
| Abstract |
Astrocytomas are the most common primary brain tumors. They are very resistant to therapies and usually progress rapidly to high-grade lesions. Here, we investigated the potential role of DNA repair genes in astrocytoma progression and resistance. To this aim, we performed a polymerase chain reaction array-based analysis focused on DNA repair genes and searched for correlations between expression patters and survival prognoses. We found 19 genes significantly altered. Combining these genes in all possible arrangements, we found 421 expression signatures strongly associated with poor survival. Importantly, five genes (DDB2, EXO1, NEIL3, BRCA2, and BRIP1) were independently correlated with worse prognoses, revealing single-gene signatures. Moreover, silencing of EXO1, which is remarkably overexpressed, promoted faster restoration of double-strand breaks, while NEIL3 knockdown, also highly overexpressed, caused an increment in DNA damage and cell death after irradiation of glioblastoma cells. These results disclose the importance of DNA repair pathways for the maintenance of genomic stability of high-grade astrocytomas and suggest that EXO1 and NEIL3 overexpression confers more efficiency for double-strand break repair and resistance to reactive oxygen species, respectively. Thereby, we highlight these two genes as potentially related with tumor aggressiveness and promising candidates as novel therapeutic targets. |
| Address |
7 Center for Integrative Systems Biology (CISBi), NAP/USP, Ribeirao Preto, Brazil |
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1010-4283 |
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PMID:28378638 |
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no |
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ref @ user @ |
Serial |
96598 |
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Correa, E.N.; Padez, C.M.P.; Abreu, A.H. de; Vasconcelos, F. de A.G. de |
| Title |
Geographic and socioeconomic distribution of food vendors: a case study of a municipality in the Southern Brazil |
Type |
Journal Article |
| Year |
2017 |
Publication |
Cadernos de Saude Publica |
Abbreviated Journal |
Cad Saude Publica |
| Volume |
33 |
Issue |
2 |
Pages |
e00145015 |
| Keywords |
Brazil; Commerce/*statistics & numerical data; Cross-Sectional Studies; Food/*statistics & numerical data; *Food Supply; Geography; Humans; Population Density; Poverty; Socioeconomic Factors; Statistics, Nonparametric |
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The objective of this study was to identify the food vendor distribution profile of the city of Florianopolis, Santa Catarina State, Brazil, and investigate its association with the socioeconomic and demographic characteristics of different municipal regions. This descriptive, cross-sectional study obtained the location of food vendors from secondary data from different institutional sources. The density of different types of food vendors per 1,000 inhabitants in each municipal weighted area was calculated. The Kruskal-Wallis test compared the mean density of food vendors and the weighted income areas. The lowest-income regions had the lowest density of butchers, snack bars, supermarkets, bakeries/pastry shops, natural product stores, juice bars, and convenience stores. The identification of these areas may encourage the creation of public policies that facilitate healthy food startups and/or maintenance of healthy food vendors, especially in the lowest-income regions. |
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Centro de Ciencias da Saude, Universidade Federal de Santa Catarina, Florianopolis, Brasil |
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English |
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0102-311X |
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| Notes |
PMID:28380124 |
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no |
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ref @ user @ |
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98027 |
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Jorge, K.O.; Ferreira, R.C.; Ferreira, E.F.E.; Vale, M.P.; Kawachi, I.; Zarzar, P.M. |
| Title |
Binge drinking and associated factors among adolescents in a city in southeastern Brazil: a longitudinal study |
Type |
Journal Article |
| Year |
2017 |
Publication |
Cadernos de Saude Publica |
Abbreviated Journal |
Cad Saude Publica |
| Volume |
33 |
Issue |
2 |
Pages |
e00183115 |
| Keywords |
Adolescent; Binge Drinking/*epidemiology; Brazil/epidemiology; Female; Humans; Longitudinal Studies; Male; Risk Factors; Socioeconomic Factors; Surveys and Questionnaires; Underage Drinking/*statistics & numerical data; Young Adult |
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The aim of this study was to investigate changes in the frequency of binge drinking and associated factors in the city of Belo Horizonte, Minas Gerais State, Brazil. The sample consisted of 436 adolescents. Data collection involved the Alcohol Use Disorders Identification Test and the Alcohol, Smoking and Substance Involvement Screening Test. Ordinal logistic regression was used in the multivariate analysis. An increase in the frequency of binge drinking was found among adolescents who lived in areas of greater social vulnerability (OR = 1.64; 95%CI: 1.01-2.68), those whose mothers consumed alcoholic beverages (OR = 1.75; 95%CI: 1.05-2.92), those whose fathers consumed alcoholic beverages (OR = 2.02; 95%CI: 1.11-3.68), those with an increased risk of tobacco use (OR = 2.82; 95%CI: 1.07-7.42) and those who attended religious services (OR = 2.10; 95%CI: 1.30-3.38). Knowledge regarding factors associated with a change in the frequency of binge drinking among adolescents can assist in the establishment of public policies directed at health promotion and the prevention of adverse health conditions. |
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Universidade Federal de Minas Gerais, Belo Horizonte, Brasil |
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English |
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0102-311X |
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| Notes |
PMID:28380128 |
Approved |
no |
| Call Number |
ref @ user @ |
Serial |
98026 |
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Gomes, F. da S.; Silva, G.A.E.; Castro, I.R.R. de |
| Title |
[Household purchase of sodas and cookies reduces the effect of an intervention to promote the consumption of fruits and vegetables] |
Type |
Journal Article |
| Year |
2017 |
Publication |
Cadernos de Saude Publica |
Abbreviated Journal |
Cad Saude Publica |
| Volume |
33 |
Issue |
3 |
Pages |
e00023316 |
| Keywords |
Beverages/*statistics & numerical data; Brazil; Candy/*statistics & numerical data; Diet Surveys; *Feeding Behavior; Female; *Fruit; *Health Promotion; Humans; Male; Socioeconomic Factors; *Vegetables |
| Abstract |
This study examines the influence of increasing household availability of sodas and cookies on the effects of an intervention to promote the consumption of fruits and vegetables. The study analyzed data from 70 families living in low-income communities in the city of Rio de Janeiro, Brazil, selected in a stratified probabilistic sample, and who completed a 30-day food record before and after the intervention. The intervention contributed to a significant increase in the household availability of fruit and vegetables (+2.7 p.p.; 95%CI: 1.5; 4.0), contrary to the trend towards stagnation of such availability in the general population in Brazil. Meanwhile, the purchase of sodas and cookies, which was not the intervention's target, mirrored the upward trend in the consumption of these products (+5.8 p.p.; 95%CI: 3.3; 8.4). Families that increased their purchase of sodas and cookies showed lower increases, or even decreases, in the purchase of fruits and vegetables (p < 0.05), and had nearly fourfold lower odds of experiencing any increase in the household availability of fruits and vegetables. |
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Instituto de Nutricao, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brasil |
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Portuguese |
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Aquisicao domiciliar de refrigerantes e de biscoitos reduz o efeito de uma intervencao de promocao de frutas e hortalicas |
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0102-311X |
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| Notes |
PMID:28380139 |
Approved |
no |
| Call Number |
ref @ user @ |
Serial |
98025 |
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