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Author |
Jorge, K.O.; Ferreira, R.C.; Ferreira, E.F.E.; Vale, M.P.; Kawachi, I.; Zarzar, P.M. |
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Title |
Binge drinking and associated factors among adolescents in a city in southeastern Brazil: a longitudinal study |
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Journal Article |
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Year |
2017 |
Publication  |
Cadernos de Saude Publica |
Abbreviated Journal |
Cad Saude Publica |
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Volume |
33 |
Issue |
2 |
Pages |
e00183115 |
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Keywords |
Adolescent; Binge Drinking/*epidemiology; Brazil/epidemiology; Female; Humans; Longitudinal Studies; Male; Risk Factors; Socioeconomic Factors; Surveys and Questionnaires; Underage Drinking/*statistics & numerical data; Young Adult |
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Abstract |
The aim of this study was to investigate changes in the frequency of binge drinking and associated factors in the city of Belo Horizonte, Minas Gerais State, Brazil. The sample consisted of 436 adolescents. Data collection involved the Alcohol Use Disorders Identification Test and the Alcohol, Smoking and Substance Involvement Screening Test. Ordinal logistic regression was used in the multivariate analysis. An increase in the frequency of binge drinking was found among adolescents who lived in areas of greater social vulnerability (OR = 1.64; 95%CI: 1.01-2.68), those whose mothers consumed alcoholic beverages (OR = 1.75; 95%CI: 1.05-2.92), those whose fathers consumed alcoholic beverages (OR = 2.02; 95%CI: 1.11-3.68), those with an increased risk of tobacco use (OR = 2.82; 95%CI: 1.07-7.42) and those who attended religious services (OR = 2.10; 95%CI: 1.30-3.38). Knowledge regarding factors associated with a change in the frequency of binge drinking among adolescents can assist in the establishment of public policies directed at health promotion and the prevention of adverse health conditions. |
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Universidade Federal de Minas Gerais, Belo Horizonte, Brasil |
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0102-311X |
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PMID:28380128 |
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no |
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Call Number |
ref @ user @ |
Serial |
98026 |
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Author |
Correa, E.N.; Padez, C.M.P.; Abreu, A.H. de; Vasconcelos, F. de A.G. de |
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Title |
Geographic and socioeconomic distribution of food vendors: a case study of a municipality in the Southern Brazil |
Type |
Journal Article |
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Year |
2017 |
Publication |
Cadernos de Saude Publica |
Abbreviated Journal |
Cad Saude Publica |
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Volume |
33 |
Issue |
2 |
Pages |
e00145015 |
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Keywords |
Brazil; Commerce/*statistics & numerical data; Cross-Sectional Studies; Food/*statistics & numerical data; *Food Supply; Geography; Humans; Population Density; Poverty; Socioeconomic Factors; Statistics, Nonparametric |
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Abstract |
The objective of this study was to identify the food vendor distribution profile of the city of Florianopolis, Santa Catarina State, Brazil, and investigate its association with the socioeconomic and demographic characteristics of different municipal regions. This descriptive, cross-sectional study obtained the location of food vendors from secondary data from different institutional sources. The density of different types of food vendors per 1,000 inhabitants in each municipal weighted area was calculated. The Kruskal-Wallis test compared the mean density of food vendors and the weighted income areas. The lowest-income regions had the lowest density of butchers, snack bars, supermarkets, bakeries/pastry shops, natural product stores, juice bars, and convenience stores. The identification of these areas may encourage the creation of public policies that facilitate healthy food startups and/or maintenance of healthy food vendors, especially in the lowest-income regions. |
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Centro de Ciencias da Saude, Universidade Federal de Santa Catarina, Florianopolis, Brasil |
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0102-311X |
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PMID:28380124 |
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Call Number |
ref @ user @ |
Serial |
98027 |
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Author |
Ferrari, T.K.; Cesar, C.L.G.; Alves, M.C.G.P.; Barros, M.B. de A.; Goldbaum, M.; Fisberg, R.M. |
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Title |
[Healthy lifestyle in Sao Paulo, Brazil] |
Type |
Journal Article |
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Year |
2017 |
Publication |
Cadernos de Saude Publica |
Abbreviated Journal |
Cad Saude Publica |
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Volume |
33 |
Issue |
1 |
Pages |
e00188015 |
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Keywords |
Adolescent; Adult; Aged; Alcoholism/*epidemiology; Brazil/epidemiology; Child; Cross-Sectional Studies; *Exercise; *Feeding Behavior; Female; *Healthy Lifestyle; Humans; Male; Middle Aged; Smoking/*epidemiology; Socioeconomic Factors; Young Adult |
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The objective was to analyze adolescent, adult, and elderly lifestyles in the city of Sao Paulo, Brazil, according to demographic and socioeconomic variables. A cross-sectional, population-based study was performed with data from the Health Survey in Sao Paulo City (ISA-Capital 2008) database. Lifestyle was defined on the basis of physical activity, diet, smoking, and alcohol abuse and addiction, according to the respective guidelines. Prevalence of healthy lifestyle was 36.9% in the elderly, 15.4% in adults, and 9.8% in adolescents, and was higher in females in the elderly and adults. Among individuals with unhealthy lifestyle, 51.5% of the elderly, 32.2% of adults, and 57.9% of adolescents failed to reach the guidelines for adequate diet. Prevalence of healthy lifestyle was highest among the elderly, followed by adults and adolescents. Food consumption was the main factor associated with unhealthy lifestyle, demonstrating the importance of interventions to promote healthy lifestyle, especially adequate diet. |
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Faculdade de Saude Publica, Universidade de Sao Paulo, Sao Paulo, Brasil |
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Portuguese |
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Original Title |
Estilo de vida saudavel em Sao Paulo, Brasil |
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0102-311X |
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PMID:28125129 |
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Call Number |
ref @ user @ |
Serial |
98028 |
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Author |
Yin, J.; Oh, Y.T.; Kim, J.-Y.; Kim, S.S.; Choi, E.; Kim, T.H.; Hong, J.H.; Chang, N.; Cho, H.J.; Sa, J.K.; Kim, J.C.; Kwon, H.J.; Park, S.; Lin, W.; Nakano, I.; Gwak, H.-S.; Yoo, H.; Lee, S.-H.; Lee, J.; Kim, J.H.; Kim, S.-Y.; Nam, D.-H.; Park, M.-J.; Park, J.B. |
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Title |
Transglutaminase 2 Inhibition Reverses Mesenchymal Transdifferentiation of Glioma Stem Cells by Regulating C/EBPbeta Signaling |
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Journal Article |
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Year |
2017 |
Publication |
Cancer Research |
Abbreviated Journal |
Cancer Res |
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Volume |
77 |
Issue |
18 |
Pages |
4973-4984 |
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Necrosis is a hallmark of glioblastoma (GBM) and is responsible for poor prognosis and resistance to conventional therapies. However, the molecular mechanisms underlying necrotic microenvironment-induced malignancy of GBM have not been elucidated. Here, we report that transglutaminase 2 (TGM2) is upregulated in the perinecrotic region of GBM and triggered mesenchymal (MES) transdifferentiation of glioma stem cells (GSC) by regulating master transcription factors (TF), such as C/EBPbeta, TAZ, and STAT3. TGM2 expression was induced by macrophages/microglia-derived cytokines via NF-kappaB activation and further degraded DNA damage-inducible transcript 3 (GADD153) to induce C/EBPbeta expression, resulting in expression of the MES transcriptome. Downregulation of TGM2 decreased sphere-forming ability, tumor size, and radioresistance and survival in a xenograft mouse model through a loss of the MES signature. A TGM2-specific inhibitor GK921 blocked MES transdifferentiation and showed significant therapeutic efficacy in mouse models of GSC. Moreover, TGM2 expression was significantly increased in recurrent MES patients and inversely correlated with patient prognosis. Collectively, our results indicate that TGM2 is a key molecular switch of necrosis-induced MES transdifferentiation and an important therapeutic target for MES GBM. Cancer Res; 77(18); 4973-84. (c)2017 AACR. |
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Specific Organs Cancer Branch, Research Institute and Hospital, National Cancer Center, Goyang, Korea |
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0008-5472 |
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PMID:28754668 |
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no |
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Call Number |
ref @ user @ |
Serial |
96575 |
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Author |
Yan, H.; Romero-Lopez, M.; Benitez, L.I.; Di, K.; Frieboes, H.B.; Hughes, C.C.W.; Bota, D.A.; Lowengrub, J.S. |
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3D Mathematical Modeling of Glioblastoma Suggests That Transdifferentiated Vascular Endothelial Cells Mediate Resistance to Current Standard-of-Care Therapy |
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Journal Article |
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Year |
2017 |
Publication |
Cancer Research |
Abbreviated Journal |
Cancer Res |
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Volume |
77 |
Issue |
15 |
Pages |
4171-4184 |
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Keywords |
Brain Neoplasms/*pathology; Cell Transdifferentiation/physiology; Endothelial Cells/*pathology; Glioblastoma/*pathology; Humans; *Models, Theoretical; Neoplastic Stem Cells/*pathology |
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Glioblastoma (GBM), the most aggressive brain tumor in human patients, is decidedly heterogeneous and highly vascularized. Glioma stem/initiating cells (GSC) are found to play a crucial role by increasing cancer aggressiveness and promoting resistance to therapy. Recently, cross-talk between GSC and vascular endothelial cells has been shown to significantly promote GSC self-renewal and tumor progression. Furthermore, GSC also transdifferentiate into bona fide vascular endothelial cells (GEC), which inherit mutations present in GSC and are resistant to traditional antiangiogenic therapies. Here we use three-dimensional mathematical modeling to investigate GBM progression and response to therapy. The model predicted that GSCs drive invasive fingering and that GEC spontaneously form a network within the hypoxic core, consistent with published experimental findings. Standard-of-care treatments using DNA-targeted therapy (radiation/chemo) together with antiangiogenic therapies reduced GBM tumor size but increased invasiveness. Anti-GEC treatments blocked the GEC support of GSCs and reduced tumor size but led to increased invasiveness. Anti-GSC therapies that promote differentiation or disturb the stem cell niche effectively reduced tumor invasiveness and size, but were ultimately limited in reducing tumor size because GECs maintain GSCs. Our study suggests that a combinatorial regimen targeting the vasculature, GSCs, and GECs, using drugs already approved by the FDA, can reduce both tumor size and invasiveness and could lead to tumor eradication. Cancer Res; 77(15); 4171-84. (c)2017 AACR. |
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Center for Complex Biological Systems, University of California, Irvine, California |
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English |
Summary Language |
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0008-5472 |
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PMID:28536277 |
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Call Number |
ref @ user @ |
Serial |
96585 |
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