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Author Navarrete-Reyes, A.P.; Medina-Rimoldi, C.T.; Avila-Funes, J.A.
Title (up) Correlates of subjective transportation deficiency among older adults attending outpatient clinics in a tertiary care hospital in Mexico City Type Journal Article
Year 2017 Publication Geriatrics & Gerontology International Abbreviated Journal Geriatr Gerontol Int
Volume Issue Pages
Keywords Latin America; disability; mobility; older adults; transportation
Abstract AIM: Older adults frequently report problems of transportation. Little is known about the correlates of transportation deficiency in Latin America. Therefore, the aim of the present study was to determine the correlates of subjective transportation deficiency (STD) among community-dwelling older adults attending a tertiary care hospital in Mexico City. METHODS: Cross-sectional study of 228 participants aged >/=70 years being followed in any of the outpatient clinics of a tertiary care hospital in Mexico City. Data were obtained through a structured questionnaire. Univariate and multivariate logistic regression analyses were carried out in order to identify the correlates of STD. RESULTS: The mean age of the participants was 79.8 years (SD 6.4) and 67.1% were women. STD was present in 46% of participants. The multivariate logistic regression model showed that female sex, illiteracy, mobility disability and the use of an assistive walking device had an independent and statistically significant association with STD. CONCLUSIONS: Female sex, illiteracy, mobility disability and the use of an assistive walking device were independent correlates of STD in the present study. Identifying the frequency and correlates of transportation deficiency in vulnerable populations will allow for the identification and implementation of useful public policies, as well as for the optimization of prevention and treatment strategies in an attempt to preserve mobility and autonomy, especially in low- and middle-income countries where previous work on transportation deficiency is lacking. Geriatr Gerontol Int 2016; : -**.
Address Research Center INSERM, Bordeaux, France
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1447-0594 ISBN Medium
Area Expedition Conference
Notes PMID:28190303 Approved no
Call Number ref @ user @ Serial 97125
Permanent link to this record
 

 
Author Navarrete-Reyes, A.P.; Medina-Rimoldi, C.T.; Avila-Funes, J.A.
Title (up) Correlates of subjective transportation deficiency among older adults attending outpatient clinics in a tertiary care hospital in Mexico City Type Journal Article
Year 2017 Publication Geriatrics & Gerontology International Abbreviated Journal Geriatr Gerontol Int
Volume Issue Pages
Keywords Latin America; disability; mobility; older adults; transportation
Abstract AIM: Older adults frequently report problems of transportation. Little is known about the correlates of transportation deficiency in Latin America. Therefore, the aim of the present study was to determine the correlates of subjective transportation deficiency (STD) among community-dwelling older adults attending a tertiary care hospital in Mexico City. METHODS: Cross-sectional study of 228 participants aged >/=70 years being followed in any of the outpatient clinics of a tertiary care hospital in Mexico City. Data were obtained through a structured questionnaire. Univariate and multivariate logistic regression analyses were carried out in order to identify the correlates of STD. RESULTS: The mean age of the participants was 79.8 years (SD 6.4) and 67.1% were women. STD was present in 46% of participants. The multivariate logistic regression model showed that female sex, illiteracy, mobility disability and the use of an assistive walking device had an independent and statistically significant association with STD. CONCLUSIONS: Female sex, illiteracy, mobility disability and the use of an assistive walking device were independent correlates of STD in the present study. Identifying the frequency and correlates of transportation deficiency in vulnerable populations will allow for the identification and implementation of useful public policies, as well as for the optimization of prevention and treatment strategies in an attempt to preserve mobility and autonomy, especially in low- and middle-income countries where previous work on transportation deficiency is lacking. Geriatr Gerontol Int 2016; : -**.
Address Research Center INSERM, Bordeaux, France
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1447-0594 ISBN Medium
Area Expedition Conference
Notes PMID:28190303 Approved no
Call Number ref @ user @ Serial 97146
Permanent link to this record
 

 
Author Navarrete-Reyes, A.P.; Medina-Rimoldi, C.T.; Avila-Funes, J.A.
Title (up) Correlates of subjective transportation deficiency among older adults attending outpatient clinics in a tertiary care hospital in Mexico City Type Journal Article
Year 2017 Publication Geriatrics & Gerontology International Abbreviated Journal Geriatr Gerontol Int
Volume Issue Pages
Keywords Latin America; disability; mobility; older adults; transportation
Abstract AIM: Older adults frequently report problems of transportation. Little is known about the correlates of transportation deficiency in Latin America. Therefore, the aim of the present study was to determine the correlates of subjective transportation deficiency (STD) among community-dwelling older adults attending a tertiary care hospital in Mexico City. METHODS: Cross-sectional study of 228 participants aged >/=70 years being followed in any of the outpatient clinics of a tertiary care hospital in Mexico City. Data were obtained through a structured questionnaire. Univariate and multivariate logistic regression analyses were carried out in order to identify the correlates of STD. RESULTS: The mean age of the participants was 79.8 years (SD 6.4) and 67.1% were women. STD was present in 46% of participants. The multivariate logistic regression model showed that female sex, illiteracy, mobility disability and the use of an assistive walking device had an independent and statistically significant association with STD. CONCLUSIONS: Female sex, illiteracy, mobility disability and the use of an assistive walking device were independent correlates of STD in the present study. Identifying the frequency and correlates of transportation deficiency in vulnerable populations will allow for the identification and implementation of useful public policies, as well as for the optimization of prevention and treatment strategies in an attempt to preserve mobility and autonomy, especially in low- and middle-income countries where previous work on transportation deficiency is lacking. Geriatr Gerontol Int 2016; : -**.
Address Research Center INSERM, Bordeaux, France
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1447-0594 ISBN Medium
Area Expedition Conference
Notes PMID:28190303 Approved no
Call Number ref @ user @ Serial 97336
Permanent link to this record
 

 
Author Navarrete-Reyes, A.P.; Medina-Rimoldi, C.T.; Avila-Funes, J.A.
Title (up) Correlates of subjective transportation deficiency among older adults attending outpatient clinics in a tertiary care hospital in Mexico City Type Journal Article
Year 2017 Publication Geriatrics & Gerontology International Abbreviated Journal Geriatr Gerontol Int
Volume Issue Pages
Keywords Latin America; disability; mobility; older adults; transportation
Abstract AIM: Older adults frequently report problems of transportation. Little is known about the correlates of transportation deficiency in Latin America. Therefore, the aim of the present study was to determine the correlates of subjective transportation deficiency (STD) among community-dwelling older adults attending a tertiary care hospital in Mexico City. METHODS: Cross-sectional study of 228 participants aged >/=70 years being followed in any of the outpatient clinics of a tertiary care hospital in Mexico City. Data were obtained through a structured questionnaire. Univariate and multivariate logistic regression analyses were carried out in order to identify the correlates of STD. RESULTS: The mean age of the participants was 79.8 years (SD 6.4) and 67.1% were women. STD was present in 46% of participants. The multivariate logistic regression model showed that female sex, illiteracy, mobility disability and the use of an assistive walking device had an independent and statistically significant association with STD. CONCLUSIONS: Female sex, illiteracy, mobility disability and the use of an assistive walking device were independent correlates of STD in the present study. Identifying the frequency and correlates of transportation deficiency in vulnerable populations will allow for the identification and implementation of useful public policies, as well as for the optimization of prevention and treatment strategies in an attempt to preserve mobility and autonomy, especially in low- and middle-income countries where previous work on transportation deficiency is lacking. Geriatr Gerontol Int 2016; : -**.
Address Research Center INSERM, Bordeaux, France
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1447-0594 ISBN Medium
Area Expedition Conference
Notes PMID:28190303 Approved no
Call Number ref @ user @ Serial 97448
Permanent link to this record
 

 
Author Gersey, Z.C.; Rodriguez, G.A.; Barbarite, E.; Sanchez, A.; Walters, W.M.; Ohaeto, K.C.; Komotar, R.J.; Graham, R.M.
Title (up) Curcumin decreases malignant characteristics of glioblastoma stem cells via induction of reactive oxygen species Type Journal Article
Year 2017 Publication BMC Cancer Abbreviated Journal BMC Cancer
Volume 17 Issue 1 Pages 99
Keywords Acetylcysteine/pharmacology; Adult; Antineoplastic Agents/*pharmacology; Cell Proliferation/drug effects; Cell Survival/drug effects; Curcumin/*pharmacology; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Free Radical Scavengers; Glioblastoma/drug therapy/pathology; Humans; Inhibitor of Apoptosis Proteins/metabolism; Inhibitory Concentration 50; Mitogen-Activated Protein Kinases/metabolism; Neoplastic Stem Cells/*drug effects; Oxidative Stress; Reactive Oxygen Species/*metabolism; STAT3 Transcription Factor/metabolism; Tumor Cells, Cultured; Brain tumor; Curcumin; Glioblastoma; Natural product; Reactive oxygen species; Stat3; Stem cell
Abstract BACKGROUND: Glioblastoma Multiforme (GBM) is the most common and lethal form of primary brain tumor in adults. Following standard treatment of surgery, radiation and chemotherapy, patients are expected to survive 12-14 months. Theorized cause of disease recurrence in these patients is tumor cell repopulation through the proliferation of treatment-resistant cancer stem cells. Current research has revealed curcumin, the principal ingredient in turmeric, can modulate multiple signaling pathways important for cancer stem cell self-renewal and survival. METHODS: Following resection, tumor specimens were dissociated and glioblastoma stem cells (GSCs) were propagated in neurosphere media and characterized via immunocytochemistry. Cell viability was determined with MTS assay. GSC proliferation, sphere forming and colony forming assays were conducted through standard counting methods. Reactive oxygen species (ROS) production was examined using the fluorescent molecular probe CM-H2DCFA. Effects on cell signaling pathways were elucidated by western blot. RESULTS: We evaluate the effects of curcumin on patient-derived GSC lines. We demonstrate a curcumin-induced dose-dependent decrease in GSC viability with an approximate IC50 of 25 muM. Treatment with sub-toxic levels (2.5 muM) of curcumin significantly decreased GSC proliferation, sphere forming ability and colony forming potential. Curcumin induced ROS, promoted MAPK pathway activation, downregulated STAT3 activity and IAP family members. Inhibition of ROS with the antioxidant N-acetylcysteine reversed these effects indicating a ROS dependent mechanism. CONCLUSIONS: Discoveries made in this investigation may lead to a non-toxic intervention designed to prevent recurrence in glioblastoma by targeting glioblastoma stem cells.
Address Department of Neurological Surgery, University of Miami Brain Tumor Initiative (UMBTI) Research Laboratory, Lois Pope LIFE Center, 2nd Floor, 1095 NW 14th Terrace, Miami, Florida, 33136, USA. rgraham@med.miami.edu
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1471-2407 ISBN Medium
Area Expedition Conference
Notes PMID:28160777 Approved no
Call Number ref @ user @ Serial 96610
Permanent link to this record