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Author de Sousa, J.F.; Torrieri, R.; Serafim, R.B.; Di Cristofaro, L.F.M.; Escanfella, F.D.; Ribeiro, R.; Zanette, D.L.; Paco-Larson, M.L.; da Silva, W.A.J.; Tirapelli, D.P. da C.; Neder, L.; Carlotti, C.G.J.; Valente, V.
Title Expression signatures of DNA repair genes correlate with survival prognosis of astrocytoma patients Type Journal Article
Year 2017 Publication Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine Abbreviated Journal Tumour Biol
Volume 39 Issue 4 Pages 1010428317694552
Keywords Apoptosis; Astrocytoma/genetics/metabolism/*mortality; Brain Neoplasms/genetics/metabolism/*mortality; Cell Cycle; Cell Line, Tumor; *DNA Repair; DNA Repair Enzymes/genetics/metabolism; Exodeoxyribonucleases/genetics/metabolism; Gene Expression; Humans; Kaplan-Meier Estimate; N-Glycosyl Hydrolases/genetics/metabolism; Prognosis; DNA repair; astrocytoma; genomic instability; glioblastoma; tumor progression
Abstract Astrocytomas are the most common primary brain tumors. They are very resistant to therapies and usually progress rapidly to high-grade lesions. Here, we investigated the potential role of DNA repair genes in astrocytoma progression and resistance. To this aim, we performed a polymerase chain reaction array-based analysis focused on DNA repair genes and searched for correlations between expression patters and survival prognoses. We found 19 genes significantly altered. Combining these genes in all possible arrangements, we found 421 expression signatures strongly associated with poor survival. Importantly, five genes (DDB2, EXO1, NEIL3, BRCA2, and BRIP1) were independently correlated with worse prognoses, revealing single-gene signatures. Moreover, silencing of EXO1, which is remarkably overexpressed, promoted faster restoration of double-strand breaks, while NEIL3 knockdown, also highly overexpressed, caused an increment in DNA damage and cell death after irradiation of glioblastoma cells. These results disclose the importance of DNA repair pathways for the maintenance of genomic stability of high-grade astrocytomas and suggest that EXO1 and NEIL3 overexpression confers more efficiency for double-strand break repair and resistance to reactive oxygen species, respectively. Thereby, we highlight these two genes as potentially related with tumor aggressiveness and promising candidates as novel therapeutic targets.
Address 7 Center for Integrative Systems Biology (CISBi), NAP/USP, Ribeirao Preto, Brazil
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1010-4283 ISBN Medium
Area Expedition Conference
Notes PMID:28378638 Approved no
Call Number ref @ user @ Serial 96598
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Author Correa, E.N.; Padez, C.M.P.; Abreu, A.H. de; Vasconcelos, F. de A.G. de
Title Geographic and socioeconomic distribution of food vendors: a case study of a municipality in the Southern Brazil Type Journal Article
Year 2017 Publication Cadernos de Saude Publica Abbreviated Journal Cad Saude Publica
Volume 33 Issue 2 Pages e00145015
Keywords Brazil; Commerce/*statistics & numerical data; Cross-Sectional Studies; Food/*statistics & numerical data; *Food Supply; Geography; Humans; Population Density; Poverty; Socioeconomic Factors; Statistics, Nonparametric
Abstract The objective of this study was to identify the food vendor distribution profile of the city of Florianopolis, Santa Catarina State, Brazil, and investigate its association with the socioeconomic and demographic characteristics of different municipal regions. This descriptive, cross-sectional study obtained the location of food vendors from secondary data from different institutional sources. The density of different types of food vendors per 1,000 inhabitants in each municipal weighted area was calculated. The Kruskal-Wallis test compared the mean density of food vendors and the weighted income areas. The lowest-income regions had the lowest density of butchers, snack bars, supermarkets, bakeries/pastry shops, natural product stores, juice bars, and convenience stores. The identification of these areas may encourage the creation of public policies that facilitate healthy food startups and/or maintenance of healthy food vendors, especially in the lowest-income regions.
Address Centro de Ciencias da Saude, Universidade Federal de Santa Catarina, Florianopolis, Brasil
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0102-311X ISBN Medium
Area Expedition Conference
Notes PMID:28380124 Approved no
Call Number ref @ user @ Serial 98027
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Author Jorge, K.O.; Ferreira, R.C.; Ferreira, E.F.E.; Vale, M.P.; Kawachi, I.; Zarzar, P.M.
Title Binge drinking and associated factors among adolescents in a city in southeastern Brazil: a longitudinal study Type Journal Article
Year 2017 Publication Cadernos de Saude Publica Abbreviated Journal Cad Saude Publica
Volume 33 Issue 2 Pages e00183115
Keywords Adolescent; Binge Drinking/*epidemiology; Brazil/epidemiology; Female; Humans; Longitudinal Studies; Male; Risk Factors; Socioeconomic Factors; Surveys and Questionnaires; Underage Drinking/*statistics & numerical data; Young Adult
Abstract The aim of this study was to investigate changes in the frequency of binge drinking and associated factors in the city of Belo Horizonte, Minas Gerais State, Brazil. The sample consisted of 436 adolescents. Data collection involved the Alcohol Use Disorders Identification Test and the Alcohol, Smoking and Substance Involvement Screening Test. Ordinal logistic regression was used in the multivariate analysis. An increase in the frequency of binge drinking was found among adolescents who lived in areas of greater social vulnerability (OR = 1.64; 95%CI: 1.01-2.68), those whose mothers consumed alcoholic beverages (OR = 1.75; 95%CI: 1.05-2.92), those whose fathers consumed alcoholic beverages (OR = 2.02; 95%CI: 1.11-3.68), those with an increased risk of tobacco use (OR = 2.82; 95%CI: 1.07-7.42) and those who attended religious services (OR = 2.10; 95%CI: 1.30-3.38). Knowledge regarding factors associated with a change in the frequency of binge drinking among adolescents can assist in the establishment of public policies directed at health promotion and the prevention of adverse health conditions.
Address Universidade Federal de Minas Gerais, Belo Horizonte, Brasil
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0102-311X ISBN Medium
Area Expedition Conference
Notes PMID:28380128 Approved no
Call Number ref @ user @ Serial 98026
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Author Gomes, F. da S.; Silva, G.A.E.; Castro, I.R.R. de
Title [Household purchase of sodas and cookies reduces the effect of an intervention to promote the consumption of fruits and vegetables] Type Journal Article
Year 2017 Publication Cadernos de Saude Publica Abbreviated Journal Cad Saude Publica
Volume 33 Issue 3 Pages e00023316
Keywords Beverages/*statistics & numerical data; Brazil; Candy/*statistics & numerical data; Diet Surveys; *Feeding Behavior; Female; *Fruit; *Health Promotion; Humans; Male; Socioeconomic Factors; *Vegetables
Abstract This study examines the influence of increasing household availability of sodas and cookies on the effects of an intervention to promote the consumption of fruits and vegetables. The study analyzed data from 70 families living in low-income communities in the city of Rio de Janeiro, Brazil, selected in a stratified probabilistic sample, and who completed a 30-day food record before and after the intervention. The intervention contributed to a significant increase in the household availability of fruit and vegetables (+2.7 p.p.; 95%CI: 1.5; 4.0), contrary to the trend towards stagnation of such availability in the general population in Brazil. Meanwhile, the purchase of sodas and cookies, which was not the intervention's target, mirrored the upward trend in the consumption of these products (+5.8 p.p.; 95%CI: 3.3; 8.4). Families that increased their purchase of sodas and cookies showed lower increases, or even decreases, in the purchase of fruits and vegetables (p < 0.05), and had nearly fourfold lower odds of experiencing any increase in the household availability of fruits and vegetables.
Address Instituto de Nutricao, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brasil
Corporate Author Thesis
Publisher Place of Publication Editor
Language Portuguese Summary Language Original Title Aquisicao domiciliar de refrigerantes e de biscoitos reduz o efeito de uma intervencao de promocao de frutas e hortalicas
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0102-311X ISBN Medium
Area Expedition Conference
Notes PMID:28380139 Approved no
Call Number ref @ user @ Serial 98025
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Author Carvalho, J.N. de; Roncalli, A.G.; Cancela, M. de C.; Souza, D.L.B. de
Title Prevalence of multimorbidity in the Brazilian adult population according to socioeconomic and demographic characteristics Type Journal Article
Year 2017 Publication PloS one Abbreviated Journal PLoS One
Volume 12 Issue 4 Pages e0174322
Keywords Adolescent; Adult; Brazil; *Comorbidity; *Demography; Female; Humans; Male; Prevalence; Socioeconomic Factors; Young Adult
Abstract Knowledge on the occurrence of multimorbidity is important from the viewpoint of public policies, as this condition increases the consumption of medicines as well as the utilization and expenses of health services, affecting life quality of the population. The objective of this study was to estimate prevalence of self-reported multimorbidity in Brazilian adults (>/=18 years old) according to socioeconomic and demographic characteristics. A descriptive study is presented herein, based on data from the National Health Survey, which was a household-based survey carried out in Brazil in 2013. Data on 60,202 adult participants over the age of 18 were included. Prevalences and its respective confidence intervals (95%) were estimated according to sex, age, education level, marital status, self-reported skin color, area of residence, occupation and federative units (states). Poisson regression models univariate and multivariate were used to evaluate the association between socioeconomic and demographic variables with multimorbidity. To observe the combinations of chronic conditions the most common groups in pairs, trios, quartets and quintets of chronic diseases were observed. The prevalence of multimorbidity was 23.6% and was higher among women, in individuals over 60 years of age, people with low educational levels, people living with partner, in urban areas and among unemployed persons. The states of the South and Southeast regions presented higher prevalence. The most common groups of chronic diseases were metabolic and musculoskeletal diseases. The results demonstrated high prevalence of multimorbidity in Brazil. The study also revealed that a considerable share of the economically active population presented two or more chronic diseases. Data of this research indicated that socioeconomic and demographic aspects must be considered during the planning of health services and development of prevention and treatment strategies for chronic diseases, and consequently, multimorbidity.
Address Collective Health Program, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brasil
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1932-6203 ISBN Medium
Area Expedition Conference
Notes PMID:28384178 Approved no
Call Number ref @ user @ Serial 97640
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