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Author Gragnani, A.; de Oliveira, A.F.; Boro, D.; Pham, T.N.; Ferreira, L.M. url  doi
openurl 
  Title Response and legislative changes after the Kiss nightclub tragedy in Santa Maria/RS/Brazil: Learning from a large-scale burn disaster Type Journal Article
  Year 2017 Publication Burns : Journal of the International Society for Burn Injuries Abbreviated Journal Burns  
  Volume (up) 43 Issue 2 Pages 343-349  
  Keywords Brazil/epidemiology; Burns/epidemiology/*prevention & control; Carbon Monoxide Poisoning/epidemiology; Crowding; Disasters/*prevention & control; Fires/legislation & jurisprudence/*prevention & control; Humans; Hydrolases/poisoning; Mass Casualty Incidents/*prevention & control/statistics & numerical data; *Public Policy; Retrospective Studies; Safety/*legislation & jurisprudence; Smoke Inhalation Injury/epidemiology; Burn disaster; Fire prevention and protection; Kiss nightclub; Legislation; Mass casualty incident; Santa Maria  
  Abstract PURPOSE: A major fire occurred on January 27, 2013, at 02:30 at Kiss nightclub in the city of Santa Maria, State of Rio Grande do Sul, in Southern Brazil. In this retrospective report, we aimed to describe the nightclub fire event, its immediate consequences, and evaluated its impact on legislation. Our objective was to disseminate the lessons we learned from this large-scale nightclub fire disaster. METHODS: We conducted a literature review in PubMed and Lilacs database from 2013 to 2015 related to the nightclub Kiss, Santa Maria, fire, burns, and similar events worldwide over the past 15 years. We searched in the general press and online media information sites, and seeking legislation about this topic at the federal level in Brazil. We reported on the legislation changes that resulted from this nightclub fire. RESULTS: Current federal legislation on fire prevention and the scope of public safety, including night clubs and discos, states is the duty of the state and everyone's responsibility, pursuant to Article 144 of the Federal Constitution of Brazil. Thus, the federal union, individual states and municipalities have the power to legislate on fire prevention, and especially to ensure the security of the population. A state law called “Law Kiss”, was passed in 2014, establishing standards on safety, prevention and protection against fire in buildings and areas of fire risk in the state of Rio Grande do Sul. On a national level, a law of prevention and fire fighting in Brazil was also drafted after the Santa Maria disaster (Law project no. 4923, 2013). Currently, this bill is still awaiting sanction before it can take effect. CONCLUSION: As we push for enactment of the national law of prevention and fire fighting in Brazil, we will continue emphasizing fire prevention, fire protection, fire fighting, means of escape and proper management. All similar events in this and other countries remind us that similar tragedies may occur anywhere, and that the analysis of facts, previous mistakes, during and after the incident are crucial to our understanding, and will help us lessen the chance of future occurrences.  
  Address Universidade Federal de Sao Paulo, Escola Paulista de Medicina, Brazil  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0305-4179 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:27663506 Approved no  
  Call Number ref @ user @ Serial 97661  
Permanent link to this record
 

 
Author Ramirez-Blanco, C.E.; Ramirez-Rivero, C.E.; Diaz-Martinez, L.A.; Sosa-Avila, L.M. url  doi
openurl 
  Title Infection in burn patients in a referral center in Colombia Type Journal Article
  Year 2017 Publication Burns : Journal of the International Society for Burn Injuries Abbreviated Journal Burns  
  Volume (up) 43 Issue 3 Pages 642-653  
  Keywords Acinetobacter Infections/drug therapy/epidemiology/microbiology; Acinetobacter baumannii; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents/therapeutic use; Bacteremia/drug therapy/*epidemiology/microbiology; Burns/*epidemiology; Catheter-Related Infections/drug therapy/*epidemiology/microbiology; Central Venous Catheters; Cephalosporins/therapeutic use; Child; Child, Preschool; Colombia/epidemiology; Drug Resistance, Microbial; Escherichia coli; Escherichia coli Infections/drug therapy/epidemiology/microbiology; Female; Folliculitis/drug therapy/*epidemiology/microbiology; Humans; Infant; Infant, Newborn; Klebsiella Infections/drug therapy/epidemiology/microbiology; Klebsiella pneumoniae; Male; Middle Aged; Oxacillin/therapeutic use; Pneumonia/drug therapy/*epidemiology/microbiology; Pseudomonas Infections/drug therapy/epidemiology/microbiology; Pseudomonas aeruginosa; Staphylococcal Infections/drug therapy/epidemiology/microbiology; Staphylococcus aureus; Urinary Tract Infections/drug therapy/*epidemiology/microbiology; Wound Infection/drug therapy/*epidemiology/microbiology; Young Adult; Burn wound infection; Burns; Health care related infection; Nosocomial infection; Pneumonia; Urinary tract infection  
  Abstract INTRODUCTION: Worldwide, burns are responsible for more than 300,000 deaths annually; infection is a major cause of morbidity and mortality in these patients. Early identification and treatment of infection improves outcome. Toward this end it's necessary to identify the institutions flora and organisms that most frequently produces infection. OBJECTIVES: To characterize infections developed by burn patients hospitalized at the University Hospital of Santander (HUS). METHODOLOGY: Burn patients hospitalized in the HUS from January 1 to December 2014 were followed. Medical information regarding infections, laboratory and pathology reports were obtained. Statistical analysis with measures of central tendency, proportions, global and specific incidence density plus overall and specific incidence was obtained. For the microbiological profile proportions were established. RESULTS: 402 burn patients were included, 234 (58.2%) men and 168 (41.8%) women, aged between 6 days and 83 years, median 12.5 years. The burn agents include scald (52.5%), fire (10.0%), gasoline (9.2%), electricity (7.5%), among others. Burn area ranged from 1% to 80% TBS. Cumulative mortality was 1.5%. 27.8% of burned patients had one or more infections. Identified infections include folliculitis (27.0%), urinary tract infection (19.0%), infection of the burn wound (10.4%), pneumonia (8.6%), Central venous catheter (7.4%), bloodstream infection (7.4%) and skin grafts infection (4.3%) among others. Bacteria were responsible for 88.5% of the cases and fungi 11.5%. The most frequently isolated germs were P. aeruginosa, A. baumannii, E. coli, S. aureus and K. pneumoniae. Most gram-negative bacteria were sensitive to Amikacin, gram positive bacteria were sensitive to multiple antibiotics. CONCLUSION: Burns is a severe trauma that occurs in adult and pediatric patients, has several causative agents and can compromise the patient's life. The burned patient is at risk for a variety of infections. According to the type of infection it is possible to infer the most common causative organisms and their antibiotic sensitivity/resistance which allow a directed early empiric treatment.  
  Address University Hospital of Santander, Universidad Industrial de Santander, Colombia. Electronic address: lumisosa@gmail.com  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0305-4179 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:28185802 Approved no  
  Call Number ref @ user @ Serial 99267  
Permanent link to this record
 

 
Author Ramirez-Blanco, C.E.; Ramirez-Rivero, C.E.; Diaz-Martinez, L.A.; Sosa-Avila, L.M. url  doi
openurl 
  Title Infection in burn patients in a referral center in Colombia Type Journal Article
  Year 2017 Publication Burns : Journal of the International Society for Burn Injuries Abbreviated Journal Burns  
  Volume (up) 43 Issue 3 Pages 642-653  
  Keywords Acinetobacter Infections/drug therapy/epidemiology/microbiology; Acinetobacter baumannii; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents/therapeutic use; Bacteremia/drug therapy/*epidemiology/microbiology; Burns/*epidemiology; Catheter-Related Infections/drug therapy/*epidemiology/microbiology; Central Venous Catheters; Cephalosporins/therapeutic use; Child; Child, Preschool; Colombia/epidemiology; Drug Resistance, Microbial; Escherichia coli; Escherichia coli Infections/drug therapy/epidemiology/microbiology; Female; Folliculitis/drug therapy/*epidemiology/microbiology; Humans; Infant; Infant, Newborn; Klebsiella Infections/drug therapy/epidemiology/microbiology; Klebsiella pneumoniae; Male; Middle Aged; Oxacillin/therapeutic use; Pneumonia/drug therapy/*epidemiology/microbiology; Pseudomonas Infections/drug therapy/epidemiology/microbiology; Pseudomonas aeruginosa; Staphylococcal Infections/drug therapy/epidemiology/microbiology; Staphylococcus aureus; Urinary Tract Infections/drug therapy/*epidemiology/microbiology; Wound Infection/drug therapy/*epidemiology/microbiology; Young Adult; Burn wound infection; Burns; Health care related infection; Nosocomial infection; Pneumonia; Urinary tract infection  
  Abstract INTRODUCTION: Worldwide, burns are responsible for more than 300,000 deaths annually; infection is a major cause of morbidity and mortality in these patients. Early identification and treatment of infection improves outcome. Toward this end it's necessary to identify the institutions flora and organisms that most frequently produces infection. OBJECTIVES: To characterize infections developed by burn patients hospitalized at the University Hospital of Santander (HUS). METHODOLOGY: Burn patients hospitalized in the HUS from January 1 to December 2014 were followed. Medical information regarding infections, laboratory and pathology reports were obtained. Statistical analysis with measures of central tendency, proportions, global and specific incidence density plus overall and specific incidence was obtained. For the microbiological profile proportions were established. RESULTS: 402 burn patients were included, 234 (58.2%) men and 168 (41.8%) women, aged between 6 days and 83 years, median 12.5 years. The burn agents include scald (52.5%), fire (10.0%), gasoline (9.2%), electricity (7.5%), among others. Burn area ranged from 1% to 80% TBS. Cumulative mortality was 1.5%. 27.8% of burned patients had one or more infections. Identified infections include folliculitis (27.0%), urinary tract infection (19.0%), infection of the burn wound (10.4%), pneumonia (8.6%), Central venous catheter (7.4%), bloodstream infection (7.4%) and skin grafts infection (4.3%) among others. Bacteria were responsible for 88.5% of the cases and fungi 11.5%. The most frequently isolated germs were P. aeruginosa, A. baumannii, E. coli, S. aureus and K. pneumoniae. Most gram-negative bacteria were sensitive to Amikacin, gram positive bacteria were sensitive to multiple antibiotics. CONCLUSION: Burns is a severe trauma that occurs in adult and pediatric patients, has several causative agents and can compromise the patient's life. The burned patient is at risk for a variety of infections. According to the type of infection it is possible to infer the most common causative organisms and their antibiotic sensitivity/resistance which allow a directed early empiric treatment.  
  Address University Hospital of Santander, Universidad Industrial de Santander, Colombia. Electronic address: lumisosa@gmail.com  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0305-4179 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:28185802 Approved no  
  Call Number ref @ user @ Serial 100297  
Permanent link to this record
 

 
Author Magrath, J.W.; Kim, Y. url  doi
openurl 
  Title Salinomycin's potential to eliminate glioblastoma stem cells and treat glioblastoma multiforme (Review) Type Journal Article
  Year 2017 Publication International Journal of Oncology Abbreviated Journal Int J Oncol  
  Volume (up) 51 Issue 3 Pages 753-759  
  Keywords  
  Abstract Glioblastoma multiforme (GBM) is the most common and deadliest form of primary brain tumor. Despite treatment with surgery, radiotherapy, and chemotherapy with the drug temozolomide, the expected survival after diagnosis remains low. The median survival is only 14.6 months and the two-year survival is a mere 30%. One reason for this is the heterogeneity of GBM including the presence of glioblastoma cancer stem cells (GSCs). GSCs are a subset of cells with the unique ability to proliferate, differentiate, and create tumors. GSCs are resistant to chemotherapy and radiation and thought to play an important role in recurrence. In order to effectively treat GBM, a drug must be identified that can kill GSCs. The ionophore salinomycin has been shown to kill cancer stem cells and is therefore a promising future treatment for GBM. This study focuses on salinomycin's potential to treat GBM including its ability to reduce the CSC population, its toxicity to normal brain cells, its mechanism of action, and its potential for combination treatment.  
  Address Department of Chemical and Biological Engineering, The University of Alabama, Tuscaloosa, AL 35487-0203, USA  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1019-6439 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:28766685 Approved no  
  Call Number ref @ user @ Serial 96573  
Permanent link to this record
 

 
Author Nunes, B.P.; Soares, M.U.; Wachs, L.S.; Volz, P.M.; Saes, M. de O.; Duro, S.M.S.; Thume, E.; Facchini, L.A. url  doi
openurl 
  Title Hospitalization in older adults: association with multimorbidity, primary health care and private health plan Type Journal Article
  Year 2017 Publication Revista de Saude Publica Abbreviated Journal Rev Saude Publica  
  Volume (up) 51 Issue Pages 43  
  Keywords Aged; Brazil; *Comorbidity; Cross-Sectional Studies; Female; Hospitalization/*statistics & numerical data; Humans; Male; Middle Aged; Prepaid Health Plans/*statistics & numerical data; Primary Health Care/*standards/statistics & numerical data; Socioeconomic Factors; Urban Population  
  Abstract OBJECTIVE: Evaluate the association of multimorbidity, primary health care model and possession of a private health plan with hospitalization. METHODS: A population-based cross-sectional study with 1,593 elderly individuals (60 years old or older) living in the urban area of the city of Bage, State of Rio Grande do Sul, Brazil. The outcome was hospitalization in the year preceding the interview. The multimorbidity was evaluated through two cut-off points (>/= 2 and >/= 3). The primary health care model was defined by residence in areas covered by traditional care or by Family Health Strategy. The older adults mentioned the possession of a private health plan. We performed a gross and adjusted analysis by Poisson regression using a hierarchical model. The adjustment included demographic, socioeconomic, functional capacity disability and health services variables. RESULTS: The occurrence of overall and non-surgical hospitalization was 17.7% (95%CI 15.8-19.6) and 10.6% (95%CI 9.1-12.1), respectively. Older adults with multimorbidity were admitted to hospitals more often when to older adults without multimorbidity, regardless of the exhibition' form of operation. Having a private health plan increased the hospitalization by 1.71 (95%CI 1.09-2.69) times among residents in the areas of the Family Health Strategy when compared to elderly residents in traditional areas without a private health plan. CONCLUSIONS: The multimorbidity increased the occurrence of hospitalizations, especially non-surgical ones. Hospitalization was more frequent in older adults with private health plan and those living in Family Health Strategy areas, regardless of the presence of multiple diseases. OBJETIVO: Avaliar a associacao da multimorbidade, modelo de atencao basica e posse de plano de saude com hospitalizacao. METODOS: Estudo transversal de base populacional com 1.593 idosos (60 anos ou mais) residentes na zona urbana do municipio de Bage, Rio Grande do Sul. O desfecho foi a hospitalizacao no ano anterior a entrevista. A multimorbidade foi avaliada por meio de dois pontos de corte (>/= 2 e >/= 3). O modelo de atencao basica foi definido pela residencia em areas cobertas pela atencao tradicional ou da Estrategia Saude da Familia. A posse de plano de saude foi referida pelos idosos. Realizou-se analise bruta e ajustada por regressao de Poisson utilizando modelo hierarquizado. O ajuste incluiu variaveis demograficas, socioeconomicas, capacidades funcionais e de servicos de saude. RESULTADOS: A ocorrencia de hospitalizacao geral e nao cirurgica foi de 17,7% (IC95% 15,8-19,6) e 10,6% (IC95% 9,1-12,1), respectivamente. Idosos com multimorbidade hospitalizaram mais em comparacao com os idosos sem multimorbidade, independentemente da forma de operacionalizacao da exposicao. O plano de saude aumentou em 1,71 (IC95% 1,09-2,69) vezes a internacao hospitalar entre residentes nas areas da Estrategia Saude da Familia em comparacao aos idosos residentes nas areas tradicionais sem plano de saude. CONCLUSOES: A multimorbidade aumentou a ocorrencia de hospitalizacoes, principalmente aquelas nao cirurgicas. Idosos com plano de saude e residentes em areas de Estrategia Saude da Familia internaram mais, independentemente da presenca de multiplas doencas.  
  Address Departamento de Medicina Social. Faculdade de Medicina. Universidade Federal de Pelotas. Pelotas, RS, Brasil  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Portuguese Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0034-8910 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:28492761 Approved no  
  Call Number ref @ user @ Serial 97638  
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