@Article{Liu_etal2017,
author="Liu, Y.
and Shen, Y.
and Sun, T.
and Yang, W.",
title="Mechanisms regulating radiosensitivity of glioma stem cells",
journal="Neoplasma",
year="2017",
volume="64",
number="5",
pages="655--665",
optkeywords="glioma stem cells",
optkeywords="radiosensitivity signaling pathways.",
abstract="Malignant glioblastoma (GBM) has become a very common and difficult brain tumor given its low cure rate and high recurrence rate. GBMs are resistant to treatments because glioma stem cells (GSCs)/glioma-initiating cells (GICs), a specific subpopulation of GBM, possess properties of tumor stem cells, such as unlimited proficiency, self-renewal, differentiation and resistance to chemotherapy and radiotherapy, and exhibit a very strong DNA repair capability. Radiotherapy has become a preponderant treatment, and researchers have found many significant tumor microenvironmental factors and valuable signaling pathways regulating the GSC radioresistance, including NOTCH, Wnt/beta-catenin, Hedgehog, STAT3, and PI3K/AKT/mTOR. Therefore, we seek to boost GSC radiosensitivity through activating or inactivating pathways alone or together to eliminate the likely source of glioma and prolong survival of patients.",
optnote="PMID:28592117",
optnote="exported from refbase (http://demo.refbase.net/show.php?record=96582), last updated on Fri, 20 Oct 2017 10:21:27 +0200",
issn="0028-2685",
doi="10.4149/neo_2017_502",
opturl="http://www.ncbi.nlm.nih.gov/pubmed/28592117"
}