%0 Journal Article
%T Mechanisms regulating radiosensitivity of glioma stem cells
%A Liu, Y.
%A Shen, Y.
%A Sun, T.
%A Yang, W.
%J Neoplasma
%D 2017
%V 64
%N 5
%@ 0028-2685
%F Liu_etal2017
%O PMID:28592117
%O exported from refbase (http://demo.refbase.net/show.php?record=96582), last updated on Fri, 20 Oct 2017 10:21:27 +0200
%X Malignant glioblastoma (GBM) has become a very common and difficult brain tumor given its low cure rate and high recurrence rate. GBMs are resistant to treatments because glioma stem cells (GSCs)/glioma-initiating cells (GICs), a specific subpopulation of GBM, possess properties of tumor stem cells, such as unlimited proficiency, self-renewal, differentiation and resistance to chemotherapy and radiotherapy, and exhibit a very strong DNA repair capability. Radiotherapy has become a preponderant treatment, and researchers have found many significant tumor microenvironmental factors and valuable signaling pathways regulating the GSC radioresistance, including NOTCH, Wnt/beta-catenin, Hedgehog, STAT3, and PI3K/AKT/mTOR. Therefore, we seek to boost GSC radiosensitivity through activating or inactivating pathways alone or together to eliminate the likely source of glioma and prolong survival of patients.
%K glioma stem cells
%K radiosensitivity signaling pathways.
%U http://www.ncbi.nlm.nih.gov/pubmed/28592117
%P 655-665