PT Journal
AU Bischof, J
   Westhoff, M
   Wagner, J
   Halatsch, M
   Trentmann, S
   Knippschild, U
   Wirtz, C
   Burster, T
TI Cancer stem cells: The potential role of autophagy, proteolysis, and cathepsins in glioblastoma stem cells
SO Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
JI Tumour Biol
PY 2017
BP 1010428317692227
VL 39
IS 3
DI 10.1177/1010428317692227
LA English
DE Animals; Autophagy; Brain Neoplasms/*metabolism/*pathology; Cathepsins/*metabolism; Glioblastoma/*metabolism/*pathology; Humans; Neoplastic Stem Cells/*metabolism/*pathology; Proteolysis; *Major histocompatibility complex class I; *autophagy; *cathepsin; *glioblastoma
AB One major obstacle in cancer therapy is chemoresistance leading to tumor recurrence and metastasis. Cancer stem cells, in particular glioblastoma stem cells, are highly resistant to chemotherapy, radiation, and immune recognition. In case of immune recognition, several survival mechanisms including, regulation of autophagy, proteases, and cell surface major histocompatibility complex class I molecules, are found in glioblastoma stem cells. In different pathways, cathepsins play a crucial role in processing functional proteins that are necessary for several processes and proper cell function. Consequently, strategies targeting these pathways in glioblastoma stem cells are promising approaches to interfere with tumor cell survival and will be discussed in this review.
ER