TY - JOUR AU - Bischof, J. AU - Westhoff, M.-A. AU - Wagner, J.E. AU - Halatsch, M.-E. AU - Trentmann, S. AU - Knippschild, U. AU - Wirtz, C.R. AU - Burster, T. PY - 2017// TI - Cancer stem cells: The potential role of autophagy, proteolysis, and cathepsins in glioblastoma stem cells T2 - Tumour Biol JO - Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine SP - 1010428317692227 VL - 39 IS - 3 KW - Animals KW - Autophagy KW - Brain Neoplasms/*metabolism/*pathology KW - Cathepsins/*metabolism KW - Glioblastoma/*metabolism/*pathology KW - Humans KW - Neoplastic Stem Cells/*metabolism/*pathology KW - Proteolysis KW - *Major histocompatibility complex class I KW - *autophagy KW - *cathepsin KW - *glioblastoma AB - One major obstacle in cancer therapy is chemoresistance leading to tumor recurrence and metastasis. Cancer stem cells, in particular glioblastoma stem cells, are highly resistant to chemotherapy, radiation, and immune recognition. In case of immune recognition, several survival mechanisms including, regulation of autophagy, proteases, and cell surface major histocompatibility complex class I molecules, are found in glioblastoma stem cells. In different pathways, cathepsins play a crucial role in processing functional proteins that are necessary for several processes and proper cell function. Consequently, strategies targeting these pathways in glioblastoma stem cells are promising approaches to interfere with tumor cell survival and will be discussed in this review. SN - 1010-4283 UR - http://www.ncbi.nlm.nih.gov/pubmed/28347245 UR - PM:28347245 N1 - PMID:28347245 ID - Bischof_etal2017 ER -