TY  - JOUR
AU  - Bischof, J.
AU  - Westhoff, M.-A.
AU  - Wagner, J.E.
AU  - Halatsch, M.-E.
AU  - Trentmann, S.
AU  - Knippschild, U.
AU  - Wirtz, C.R.
AU  - Burster, T.
PY  - 2017//
TI  - Cancer stem cells: The potential role of autophagy, proteolysis, and cathepsins in glioblastoma stem cells
T2  - Tumour Biol
JO  - Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
SP  - 1010428317692227
VL  - 39
IS  - 3
KW  - Animals
KW  - Autophagy
KW  - Brain Neoplasms/*metabolism/*pathology
KW  - Cathepsins/*metabolism
KW  - Glioblastoma/*metabolism/*pathology
KW  - Humans
KW  - Neoplastic Stem Cells/*metabolism/*pathology
KW  - Proteolysis
KW  - *Major histocompatibility complex class I
KW  - *autophagy
KW  - *cathepsin
KW  - *glioblastoma
AB  - One major obstacle in cancer therapy is chemoresistance leading to tumor recurrence and metastasis. Cancer stem cells, in particular glioblastoma stem cells, are highly resistant to chemotherapy, radiation, and immune recognition. In case of immune recognition, several survival mechanisms including, regulation of autophagy, proteases, and cell surface major histocompatibility complex class I molecules, are found in glioblastoma stem cells. In different pathways, cathepsins play a crucial role in processing functional proteins that are necessary for several processes and proper cell function. Consequently, strategies targeting these pathways in glioblastoma stem cells are promising approaches to interfere with tumor cell survival and will be discussed in this review.
SN  - 1010-4283
UR  - http://www.ncbi.nlm.nih.gov/pubmed/28347245
UR  - PM:28347245
N1  - PMID:28347245
ID  - Bischof_etal2017
ER  -